Sign inSubmit
Tips: “quotes” for a phrase · author:Lee · a DOI goes straight to its article

86 results for “drug development”
Set a search alert
Review ArticleOpen accessIn the abstractDrug Repositioning in Response to COVID-19 and other Challenging DiseasesHyellavala Joseph Fomnya, Saidu Ibrahim Ngulde, Sarah Malgwi Gana et al.Coronavirus disease is a highly contagious infection that is majorly associated with upper respiratory tract illnesses. The World Health Organization (WHO) label the novel coronavirus disease COVID-19 after an epidemic of the disease in Wuhan, Hubei province (China). Over 90 clinical trials, including drug repositioning, have been initiated to get COVID-19 treatment/management. Antibiotic resistance, drug tolerance, mutation, and adverse drug … …American Journal of Pharmacology and Toxicology, Vol. 17, Issue 1 · 28 Nov 2022 · 9,503 accessesView PDFCite
Research ArticleOpen accessIn the abstractEvaluation of an Intelligent Electronic Prescription Ontology Using Open Source Tools: A Botswana Case StudyTshiamo Sigwele, Eunice Okon, Tshepiso Mokgetse, Onkemetse TshenyegoHealthcare interoperability in Botswana is hindered by fragmented information exchange across public and private providers, resulting in prescription conflicts, duplicated treatment, and delayed care. In prior work, we developed the Intelligent Electronic Prescription Ontology (IEPO), an open-source OWL 2 ontology for semantically standardized prescription data exchange. Although IEPO was previously validated using competency question-driven metrics (recall, precision, and F1-score), those … …Journal of Computer Science, Vol. 22, Issue 10 · 29 Sep 2026 · 500 accessesView PDFCite
Review ArticleOpen accessIn the abstractBiosurfactants in the Halal Economy: Sustainable Solutions for Food, Pharma, and BeyondKanokphorn Sangkharak, Suppasil Maneerat, Aem Nuylert et al.Biosurfactants, microbial surface-active compounds, are gaining attention as sustainable, biocompatible alternatives to synthetic surfactants. Their properties, including emulsification, foaming, and antimicrobial activities, enable diverse applications in food, pharmaceutical, and cosmetic industries. With increasing demand for halal-certified products, biosurfactants offer potential as halal ingredients, provided they are produced using compliant strains, substrates, and processing methods. This review examines the production of … …American Journal of Biochemistry and Biotechnology, Vol. 22, Issue 3 · 7 Aug 2026 · 1,142 accessesView PDFCite
Research ArticleOpen accessIn the abstractImmunomodulatory and Antioxidant Effects of Stachys Japonica Miq. Ethanol Extract on Cyclophosphamide-Induced Immunosuppressed Mice and its Phytochemical CompositionXueping Jiang, Jianglong He, Yanjun Chen, Fang WangStachys japonica Miq. is an edible wild botanical drug and a traditional medicine in China. This study focused on examining the phytochemical profile and antioxidant properties of the ethanol extract of S. japonica Miq (SJEE) in vitro, as well as its immunomodulatory and antioxidant activities in cyclophosphamide (Cy)-induced immunosuppressed mice. The SJEE was analysed by UPLC-HRMS/MS. 36 Polyphenols, including flavonoids, … …American Journal of Biochemistry and Biotechnology, Vol. 22, Issue 1 · 13 Apr 2026 · 1,449 accessesView PDFCite
Case ReportOpen accessIn the abstractA Reasonable Outcome with Systemic Corticosteroids in a Case of Ibuprofen Induced Stevens-Johnson SyndromeElif Güdeloğlu, Volkan Emir AltanBoth Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are idiosyncratic severe mucocutaneous reactions, usually to drugs or infections, characterized by blistering and epithelial sloughing. Although rare, SJS and TEN are destructive diseases; in serious cases the acute phase may be followed by a variety of systemic complications, including multiorgan failure and death. Ibuprofen is a universal antipyretic and analgesic … …American Journal of Immunology, Vol. 16, Issue 1 · 4 Sep 2020 · 7,451 accessesView PDFCite
Review ArticleOpen accessIn the abstractSARS-CoV-2-Induced Damage on the Cardiovascular System: Molecular MechanismsMel·lina Pinsach-Abuin, Ramon Brugada TerradellasSince its emergence in late December 2019, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) - the causative agent of coronavirus disease 2019 (COVID-19) - has spread rapidly world-wide, becoming a global pandemic in March 2020 that is still active. In addition to the severe pulmonary damage, clinical studies have reported that COVID-19 is associated with the development of cardiovascular … …American Journal of Infectious Diseases, Vol. 17, Issue 4 · 25 Nov 2021 · 6,791 accessesView PDFCite
Research ArticleOpen accessIn the abstractKRLSMDA: Identifying Human miRNA–Disease Association Based on Similarity and Kronecker Regularized Least Squares MethodLingzhi Zhu, Weimin Gao, Guixiang Li et al.A growing number of studies have suggested that miRNAs (microRNAs) have associations with human diseases, the design and discovery of drug. But so far, we do not yet fully understand the molecular mechanism of miRNAs in the development of human diseases. Predicting miRNA-disease associations is helpful for understanding the molecular mechanism of miRNAs in the development of human diseases. However, … …American Journal of Biochemistry and Biotechnology, Vol. 17, Issue 1 · 15 Mar 2021 · 6,403 accessesView PDFCite
Research ArticleOpen accessIn the abstractAnalyzing Temperature-Dependent Thermal Properties of Titanium Aluminide Using ANN Predictive ModelingArmaghan Shalbaftabar, Kristen Rhinehardt, Dhananjay KumarThis study presents a comprehensive analysis of the thermal behavior of Titanium Aluminide (TiAl) across a range of temperatures using an Artificial Neural Network (ANN) predictive model. The study investigates various material properties of TiAl, including Band Gap, Young Module, Density, Energy Absorption, Thermal Conductivity, and Specific Heat, at different temperature points. The ANN model accurately captures the temperature-dependent trends … …American Journal of Engineering and Applied Sciences, Vol. 17, Issue 4 · 20 Nov 2024 · 4,308 accessesView PDFCite