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121 results for “cytokine”
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Review ArticleOpen accessIn the keywordsSARS-CoV-2-Induced Damage on the Cardiovascular System: Molecular MechanismsMel·lina Pinsach-Abuin, Ramon Brugada TerradellasSince its emergence in late December 2019, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) - the causative agent of coronavirus disease 2019 (COVID-19) - has spread rapidly world-wide, becoming a global pandemic in March 2020 that is still active. In addition to the severe pulmonary damage, clinical studies have reported that COVID-19 is associated with the development of cardiovascular … …American Journal of Infectious Diseases, Vol. 17, Issue 4 · 25 Nov 2021 · 6,794 accessesView PDFCite
Literature ReviewOpen accessIn the keywordsPotential Pathomechanism of Neuro-COVID-19Abir Fguirouche, Nissrine Louhab, Mohamed Chraa et al.Gathered data about SARS-CoV-2 have shown strong evidence in terms of neuroinvasive and neurotropic capacities of the virus to reach and cause eventual damage to the Central Nervous System. The spread of the virus may occur through direct and indirect ways, leading to anosmia and/or ageusia. These signs have been observed in many COVID-19 patients and are then included in … …OnLine Journal of Biological Sciences, Vol. 20, Issue 4 · 7 Dec 2020 · 6,544 accessesView PDFCite
Literature ReviewOpen accessIn the keywordsFundamental Questions about γδT CellsMoulay Yassine Belghali, Saadia Ba-M’hamed, Mouna Khouchani, Brahim AdmouγδT cells is a minor subgroup of T lymphocytes expressing γδ-T Cell Receptor (TCR), with many subsets, dominated by Vδ2 and Vδ1. γδT cells recognize antigens independently of the context of MHC class I, MHC class II, or CD1 presenting molecules. However, this recognition requires the expression of the transmembrane Butyrophilin proteins by the presenting cells. Their activation is controlled … …OnLine Journal of Biological Sciences, Vol. 20, Issue 4 · 15 Dec 2020 · 6,384 accessesView PDFCite
Research ArticleOpen accessIn the keywordsModeling Hepatocellular Toxicity of Enavatuzumab, a Humanized Anti-TweakR AntibodyDonghee Choi, Yanhong Zhu, Debra Tien Chao et al.In a Phase 1 clinical study, treatment with enavatuzumab, a humanized monoclonal antibody to TweakR, resulted in liver toxicity in a subset of patients. The objective of this current study was to evaluate the ability of preclinical studies to predict liver toxicity in humans. Enavatuzumab was evaluated in cynomolgus monkeys, where serum liver enzyme and cytokine levels were measured and … …American Journal of Pharmacology and Toxicology, Vol. 12, Issue 2 · 9 Nov 2017 · 7,721 accessesView PDFCite
Research ArticleOpen accessIn the keywordsInfluence of Probiotics on Coccidia, H. Contortus and Markers of Infection in GoatsKwaku Barima Gyenai, Mulumebet Worku, Mehrdad Tajkarimi, Salam IbrahimImmunostimulants can induce nonspecific resistance against parasites. The use of probiotics to control development of animal gastrointestinal parasites could help reduce the risks of infestation. In this study, we investigated the effects of probiotics administration on gastrointestinal parasites coccidia, H. contortus and markers of infection. A cocktail of probiotics mix including Bifidobacterium longum, Bifidobacterium breve, Lactobacillus acidophilus, Lactobacillus reuteri and … …American Journal of Animal and Veterinary Sciences, Vol. 11, Issue 3 · 29 Jul 2016 · 9,034 accessesView PDFCite
Research ArticleOpen accessIn the keywordsLACTIC ACIDOSIS AND HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS: A REVIEW OF THE LITERATURECharat Thongprayoon, Peter J. Edmonds, Patompong Ungprasert et al.Lactic acidosis is the most common cause of anion gap metabolic acidosis and is associated with high morbidity and mortality in hospitalized patients. The association between Hemophagocytic Lymphohistiocytosis (HLH) and lactic acidosis is still unclear. HLH causes cytokine overproduction which in turn induces lactic acidosis. There have been only few reports of type B lactic acidosis in HLH patients. There … …Current Research in Medicine, Vol. 5, Issue 2 · 5 Jul 2014 · 7,687 accessesView PDFCite
Research ArticleOpen accessIn the keywordsThe Flavonoid, Quercetin, Inhibits HIV-1 Infection in Normal Peripheral Blood Mononuclear CellsMadhavan P.N. Nair, Zainulabedin M. Saiyed, Nimisha H. Gandhi, C. N. RamchandProblem statement: Flavonoids and related polyphenols, have been known to possess cardioprotective, anti-tumor, anti-inflammatory, anti-allergic and anti-viral activities. Previous studies have shown that flavonoid, quercetin significantly downregulates expression of pro-inflammatory cytokines in cultured cells via modulation of NFκB and p38MAPK signaling pathways. In the current study, we hypothesize that quercetin exerts anti-HIV activity by differential modulation of pro-and anti-inflammatory cytokine … …American Journal of Infectious Diseases, Vol. 5, Issue 2 · 30 Jun 2009 · 12,190 accessesView PDFCite
Research ArticleOpen accessIn the keywordsDengue Virus Infection Induced NF-κB-dependent Macrophage Migration Inhibitory Factor ProductionLien-Cheng Chen, Huey-Wen Shyu, Huan-Yao Lei et al.Dengue virus (DV) infection can cause mild dengue fever or severe dengue hemorrhage fever and dengue shock syndrome. Macrophage migration inhibitory factor (MIF) is a cytokine that plays an important role in the modulation of inflammatory and immune responses and serum levels of MIF are correlated with disease severity in dengue patients. However, the mechanism that induces MIF production during … …American Journal of Infectious Diseases, Vol. 4, Issue 1 · 31 Mar 2008 · 7,293 accessesView PDFCite
Research ArticleOpen accessIn the keywordsImmunodeficient Parameters in the HIV-1 Transgenic Rat ModelSulie L. Chang, Frank Ocasio, Jose A. BeltranRecently an HIV-1 transgenic (HIV-1Tg) rat model was created that carries a gag-pol-deleted HIV-1 genome under the control of the HIV-1 viral promoter. However, other viral proteins are expressed in most organs and tissues, and are found in the circulating blood. Since HIV-1 targets the immune system in humans, we examined two immunological parameters, leukocyte-endothelial adhesion (LEA) and inflammatory cytokine … …American Journal of Infectious Diseases, Vol. 3, Issue 4 · 31 Dec 2007 · 7,839 accessesView PDFCite
Research ArticleOpen accessIn the keywordsProtection against Lipopolysaccharide-induced Death by An Anti-Interleukin-6 Monoclonal AntibodyBailin Liang, Debra Gardner, Don Griswold, Xiao-yu R. SongSepticemia is frequently associated with serious complications and high mortality despite recent advances in treatment with antibacterial agents. Infectious organisms or their soluble products initiate septic shock through a complex cytokine cascade. Lipopolysaccharide (LPS) induced excessive production of inflammatory cytokines is regarded as a model of septic shock. Experiments of LPS-induced excessive cytokine production were conducted in Balb/c mice for … …American Journal of Immunology, Vol. 3, Issue 1 · 30 Jun 2007 · 6,861 accessesView PDFCite