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32 articles for “analgesic”
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Research ArticleOpen accessIn the abstractAn Induced Hematoma in Caudoputamen Nuclei in Rats Causes Central Pain when the Thalamus is also Implicated and the Central Sensitization is Reversed with GabapentinP. P. Lema, P. VachonProblem statement: The objective of this study was to evaluate pain sensitisation in rats following the induction of an intracerebral hemorrhage by injecting a collagenase solution in the caudoputamen nucleus of the right basal ganglia and to evaluate gabapentin as an analgesic for central pain. Approach: Thirty male Sprague-Dawley rats weighing between 175-300 g were used. In a first experiment, … …American Journal of Animal and Veterinary Sciences, Vol. 7, Issue 1 · 10 Mar 2012 · 8,167 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffect of Intraperitoneally Injection of Different Doses of Lovastatin on Pain and Inflammatory Response Induced by Formalin in MiceKhayatnouri MirhadiProblem statement: The 3-Hydroxy-3-Methyl Glutaryl-CoA (HMG-CoA) reductase inhibitors (statins) have been unequivocally shown to reduce cardiovascular morbidity and mortality. Their lipid-lowering actions are by reversible and competitive inhibition of the enzyme HMG-CoA reductase, a precursor of cholesterol. It has been suggested that statins appear to have therapeutic benefits in diseases that are unrelated to elevated serum cholesterol levels, such as … …American Journal of Animal and Veterinary Sciences, Vol. 6, Issue 4 · 11 Jan 2012 · 7,679 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffect of Intrahippocampal γ Aminobutyrate B Receptor on Pain Sensitivity during Estrous CycleMahnaz Taherianfard, Rohollah GhorbaniProblem statement: There is a relationship between sexual hormones and pain sensitivity and also a role for hippocampal GABAB receptor in nociception. Therefore, the aim of the present investigation was to evaluate the effect of intrahippocampal injection of GABAB receptor agonist (baclofen) and GABAB receptor antagonist (CGP35348) on pain sensitivity during the estrous cycle. Approach: Forty eight adult female rats … …American Journal of Pharmacology and Toxicology, Vol. 6, Issue 3 · 26 Nov 2011 · 7,342 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffects of Intraarticular Tramadol Administration on Biochemical and Cytological Properties of Equine Synovial Fluid: Comparison with LidocaineAlireza Raayat Jahromi, Abutorab Tabatabaei Naeini, Saeed NazifiProblem statement: Diagnostic and therapeutic arthroscopic surgeries are procedures performed quite frequently in equine practice; and are considered to cause some degree of postoperative pain. The aim of the present study was to evaluate the equine synovial fluid biochemical and cytological changes following intra-articular administration of tramadol as a potential analgesic. Approach: Six adult healthy donkeys were selected after clinical … …American Journal of Pharmacology and Toxicology, Vol. 6, Issue 1 · 14 Jun 2011 · 7,514 accessesView PDFCite
Research ArticleOpen accessIn the abstractQuality evaluation of Ketoprofen Solid Dosage Forms Available in the Pharma-Market of BangladeshKamrun Naher, Gazi Md. Monjur Murshid, Md. Golam Hossain et al.Problem statement: Ketoprofen, a widely used analgesic and anti-inflammatory drug, was available in two types of solid dosage forms in the pharma-market of Bangladesh: enteric-coated tablet and capsule of sustained-release pattern. Seven brands of ketoprofen enteric-coated tablets and four brands of ketoprofen sustained release capsules were studied for their in-vitro release behavior as well as potency status. Approach: The studies … …American Journal of Applied Sciences, Vol. 7, Issue 10 · 31 Oct 2010 · 8,048 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Intracerebroventricular Administration of W-7, A Calmodulin Inhibitor, Attenuate the Development of Morphine Tolerance in RatsGholamreza Sepehri, Vahid Sheibani, Afrooz Azarang et al.Problem statement: The present study was performed to determine the effect of Intracerebroventricular (ICV) administration of W-7, a specific calmodulin inhibitor, on the analgesic effect and development of tolerance to antinociceptive effect of acute and chronic morphine administration respectively. Approach: This study was carried out on male wistar rats, weighing 200-250 g. For acute experimental protocol, Morphine was injected intraperitonealy … …American Journal of Pharmacology and Toxicology, Vol. 5, Issue 2 · 30 Jun 2010 · 7,752 accessesView PDFCite
Research ArticleOpen accessIn the abstractCharacterization of Nigella Sativa L. Essential Oil-Loaded Solid Lipid NanoparticlesNagi A. ALHaj, Mariana N. Shamsudin, Norfarrah M. Alipiah et al.Problem statement: Seeds of Nigella Sativa L., commonly known as black seed, have been used in traditional medicine by many Asian, Middle Eastern and Far Eastern Countries to treat headache, coughs, abdominal pain, diarrhea, asthma, rheumatism and other diseases. The seeds of this plant are the most extensively studied, both phytochemically and pharmacologically. The aqueous and oil extracts of the … …American Journal of Pharmacology and Toxicology, Vol. 5, Issue 1 · 31 Mar 2010 · 17,874 accessesView PDFCite
Research ArticleOpen accessIn the abstractSuspension of Certain Dental Procedures Due to COVID-19: A Source of Over-Prescription?Gowri Sivaramakrishnan, Fatema Al Sulaiti, Muneera Alsobaiei, Kannan SridharanDentists have always been attributed to the ever rising global problem of antibiotic resistance. The recent pandemic due to COVID-19 has caused greater concern and primary dental care practices temporarily suspended all aerosol generating and invasive procedures in the Ministry of Health in Bahrain, between February to August 2020. Dental emergencies were addressed using a triage system and low exposure … …Current Research in Dentistry, Vol. 12, Issue 1 · 10 Jun 2021 · 6,686 accessesView PDFCite
Research ArticleOpen accessIn the abstractComparative Evaluation of the Epidural Dexmedetomidine, Ketamine or Fentanyl in Combination with Bupivacaine in DogsEman M. Nour, Mahmoud Mahmoud Othman, Gamal I.A. Karrouf, Adel E.I. ZaghloulCastration is one of the most common procedure. It is a potential source of mild to moderate pain which is enough to induce inflammatory process, necessitate the incorporation of analgesics. This study was designed to evaluate the effect of epidural bupivacaine alone or in association with fentanyl, ketamine or dexmedetomidine on analgesia for the first 24 h post surgical castration. … …American Journal of Animal and Veterinary Sciences, Vol. 8, Issue 4 · 8 Nov 2013 · 7,188 accessesView PDFCite
Research ArticleOpen accessIn the abstractFlupirtine: A Human Drug with Potential for Use in the Veterinary FieldMario Giorgi, Helen OwenFlupirtine is a nonopioid drug without antipyretic or antiphlogistic properties and with a favorable tolerability in humans. It constitutes a unique class within the group of nonsteroidal analgesics and displays a peculiar pharmacokinetic/dynamic profile that could have large potentialities of applications in the veterinary field. This review describes and evaluates the pharmacologic literature concerning flupirtine and addresses its potential in … …American Journal of Animal and Veterinary Sciences, Vol. 7, Issue 4 · 1 Jan 2013 · 7,327 accessesView PDFCite