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31 articles for “Xen”
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Research ArticleOpen accessIn the abstractEffect of Platelet Rich Plasma on Post Cryopreservation Viability, Morphology and Proliferation of Human Umbilical Cord Stem CellsNoviyanti Goei, Isabella Kurnia Liem, Jeanne Adiwinata Pawitan, Dian MedianaIn most cryopreservation medium, Fetal Bovine Serum (FBS) is used as supplement, while it is well known that FBS contains xenoproteins that can be incorporated into the cells and may be harmfull, as they can elicit immune response. Therefore, finding other xenofree materials as FBS alternative in cryopreservation medium is very important. Platelet Rich Plasma (PRP) is albumin rich and … …OnLine Journal of Biological Sciences, Vol. 15, Issue 2 · 4 Jun 2015 · 7,386 accessesView PDFCite
Review ArticleOpen accessIn the abstractSelected Genotoxic Impurities Profiling During WFI Qualification to Control Carcinogenesis in Large Volume ParenteralsMohabbat UllahWater For Injections (WFI) which is the main vehicle of Large Volume Parenterals (LVPs) should be free from trace amount of genotoxic impurities. This review gives emphasis on quantification of genotoxic trace metals during qualification of WFI in LVPs manufacturing unit. According to ICH guidelines, impurities related to drug substances are classified into three main categories: Organic impurities, inorganic (elemental) … …American Journal of Pharmacology and Toxicology, Vol. 10, Issue 1 · 27 May 2015 · 7,708 accessesView PDFCite
Research ArticleOpen accessIn the abstractDifferential Activities of Glutathione S-Transferase Isoenzymes in Strains of Fasciola Hepatica Susceptible and Resistant to TriclabendazoleV. Fernández, P. Ortiz, M.V. Solana, H. SolanaFasciolosis, a parasitic zoonosis of intrahepatic location, is caused by the trematode Fasciola hepatica. Its control is mainly based on the use of the anthelminthic Triclabendazole (TCBZ). The indiscriminate use of this drug has favored the development of anthelmintic resistance. The Glutation S-Transferases (GSTs) are multifunctional enzymes involved in the detoxification of xenobiotics and endogenous compounds using conjugation with endogenous … …American Journal of Animal and Veterinary Sciences, Vol. 9, Issue 4 · 10 Dec 2014 · 7,574 accessesView PDFCite
Research ArticleOpen accessIn the abstractDecolorization of Mordant Orange-1 by Marinobacter algicola MO-17R. S. Shertate, Prakash ThoratProblem statement: The textile industries use different types of dyes in their processing units which are liberated in natural marine water bodies. This release of dyes in turn affect the marine flora and fauna very adversely. Approach: The release of textile dyes into the environment is a matter of concern due to the toxicity, mutagenicity, carcinogenicity and xenobiotic nature. Hence, … …OnLine Journal of Biological Sciences, Vol. 12, Issue 1 · 25 Feb 2012 · 7,513 accessesView PDFCite
Research ArticleOpen accessIn the abstractAspergillus Niger Metabolites Efficacies Against the Mosquito Larval (Culex Quinquefasciatus, Anopheles Stephensi and Aedes Aegypti) Population after Column ChromatographyNamita Soni, Soam PrakashProblem statement: Mosquito is a very common vector of several tropical diseases such as malaria, filariasis, dengue and chikungunya. Till todate, many xenobiotics have been used to control mosquito population and protect people from mosquito born diseases but increasing rate of resistance against these xenobiotics is a major concern in the disease control management. In contrast, extensive use of these … …Current Research in Microbiology, Vol. 2, Issue 1 · 21 Dec 2011 · 15,205 accessesView PDFCite
Research ArticleOpen accessIn the abstractUncommon Toxicologic Profile at Toxic Doses of CPI-613 (an Agent Selectively Alters Tumor Energy Metabolism) in Rats and Minipigs Reflects Novel MechanismClaudia Maturo, King C. Lee, Robert Rodriguez, Robert ShorrProblem statement: CPI-613 is a novel anticancer agent and the toxicological profile has not been assessed. Accordingly, the objective of these studies was to thoroughly evaluate the Toxicokinetic (TK) effects of CPI-613 in rats and to compare the toxicological profile of rats to minipigs to determine if there were differences between the two animal species. Approach: These studies involved assessments … …American Journal of Pharmacology and Toxicology, Vol. 5, Issue 4 · 13 Jun 2011 · 9,582 accessesView PDFCite
Research ArticleOpen accessIn the abstractIn Vitro Interaction of 5-Hydroxytrptamine with Cytosolic Molybdenum Hydroxylases as a Potential Inhibitor for Initial Rates ActivitiesAbdullah M. Al-Mohizea, Abd El-Galil E. Amr, Mohamed A. Al-OmarProblem statement: The role of 5-HT has been investigated in many behavioral activities. Thus, studies using raphe lesion showed that 5-HT is involved in sleep, general activity levels, habituation, aggression, pain sensitivity and morphine analgesia, avoidance behavior, self-stimulation and water consumption. Approach: The metabolic interaction between serotonin (5- hydroxytrptamine) and indole-3-aldehyde and xanthine via aldehyde oxidase (EC 1.2.3.1) and xanthine … …American Journal of Biochemistry and Biotechnology, Vol. 6, Issue 3 · 30 Sep 2010 · 7,026 accessesView PDFCite
Research ArticleOpen accessIn the abstractDegradative Plasmid and Heavy Metal Resistance Plasmid Naturally Coexist in Phenol and Cyanide Assimilating BacteriaBahig El. Deeb, Abdullah D. AltalhiProblem statement: Heavy metals are known to be powerful inhibitors of xenobiotics biodegradation activities. Alleviation the inhibitory effect of these metals on the phenol biodegradation activities in presence of heavy metals resistant plasmid was investigated. Approach: Combination of genetic systems of degradation of xenobiotic compound and heavy metal resistance was one of the approaches to the creation of polyfunctional strains … …American Journal of Biochemistry and Biotechnology, Vol. 5, Issue 2 · 30 Jun 2009 · 11,984 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Effects of Recombinant Human Erythropoietin and Tamoxifen on Growth and Angiogenesis of Mammary Tumor in Sprague-Dawley RatA. K. Sairah, A. Rasedee, O. Sheikh et al.Problem statement: Erythropoietin receptor (EPOR) has been detected in breast cancer cells and speculated to be involved in cancer growth, viability and angiogenesis. This has risen suspicious that EPO administration may enhance the severity of cancer. Approach: This study was undertaken to determine the effects of rHuEPO, Tamoxifen and their combination on the growth and angiogenesis of mammary tumor. Female … …American Journal of Pharmacology and Toxicology, Vol. 4, Issue 1 · 31 Mar 2009 · 7,804 accessesView PDFCite
Research ArticleOpen accessIn the abstractPetrology, Geochemistry and Magnetization of Remah Volcano North Eastern JordanMazen AL-AmairehPeridotite ultramafic mantle xenoliths are occurring abundantly in the Harrat Al-Shaam basaltic province. Jabal Remah volcano is located in the Jordanian parts of the plateau and contains considerable amounts of mantle xenoliths within its pyroclastic successions. Mineralogical investigations show that the xenoliths are mostly of the spinel Iherzolite type, which are characterized by a protogranular texture. Modally, the xenoliths are … …American Journal of Applied Sciences, Vol. 4, Issue 7 · 31 Jul 2007 · 7,101 accessesView PDFCite