55 articles for “Type I Resistance”

EditorialOpen accessIn the abstractFocalize the Structure of Myd88 in TLR Signaling Pathway to Modulate Innate Immune Response: New Target for Old DiseasesShuai Xing, Ping ZhouAll diseases have their Achilles’ Heel to target and this is especially true for immunorelated diseases which must be treated by targeting the immune system somewhere and somehow correctly. In the most recent decade, immunologists recognized that the Toll-Like Receptor (TLR) signaling pathway in innate immune system plays a double-edged role in the pathogenesis of many notorious diseases. Although the … …American Journal of Immunology, Vol. 13, Issue 3 · 6 Sep 2017 · 7,862 accessesView PDF Cite

Research ArticleOpen accessIn the abstractExtended-Spectrum β-Lactamases Producing Escherichia coli Strains Monitored Over 4 Years in The University Hospital in Košice, SlovakiaViera Lovayová, Lucia Vargová, Mária Nagyová et al.The beta-lactamases with extended spectrum of activity (ESBL) are medically one of the most important group of enzymes. The presented study provides identification and determination of the spectrum of resistance against different and clinically used antimicrobial drugs in the clinical isolates of Escherichia coli. These isolates had their origin in different departments of the University Hospital L. Pasteur in Košice. … …Current Research in Microbiology, Vol. 7, Issue 1 · 16 Jun 2016 · 14,537 accessesView PDF Cite

Research ArticleOpen accessIn the abstractCompaction Properties of Silty Soils in Relation to Soil Texture, Moisture Content and Organic MatterPrathuang Usaborisut, Jettapol AmpanmaneeSoil compaction is recognized as an increasingly challenging problem with regard to root growth and yield reduction in agricultural production in Thailand. The aim of this research was to study the effect of soil texture, moisture content and organic matter on the compaction properties of silty soils. Three soils with different silt contents were studied-loam, silty clay loam and silt … …American Journal of Agricultural and Biological Sciences, Vol. 10, Issue 4 · 31 Dec 2015 · 9,536 accessesView PDF Cite

EditorialOpen accessIn the abstractAntibacterial Quorum-Sensing Molecules as Long Lasting Antibacterial DrugsAnanya Pavuluri, Yan Zhang, Shanzhi WangAntibacterial quorum-sensing molecules are a new type of antibacterial reagent that blocks bacterial communications and dampens virulence. These molecules are proposed to tackle the roots of drug resistance and to be long lasting, although more research should be done toward the effectiveness and resistance of these drugs. …American Journal of Biochemistry and Biotechnology, Vol. 11, Issue 1 · 26 Jan 2015 · 6,925 accessesView PDF Cite

Research ArticleOpen accessIn the abstractProposal of a Genome Editing System for Genetic Resistance to Tomato Spotted Wilt VirusFederico Martinelli, Giovanni Grillone, Filippo SgroiViruses provoke considerable economical losses in agriculture. New molecular approaches to develop genetic resistance based on translational genomics and precision genetic modifications are highly expected. The type II Clustered, Regularly Interspaced Palindromic Repeats (CRISPR) system including Cas9 nuclease represent a promising and very powerful tool to specifically modulate the expression and activity of genes involved in biotic stress responses. In … …American Journal of Applied Sciences, Vol. 11, Issue 11 · 7 Jan 2015 · 7,685 accessesView PDF Cite

Research ArticleOpen accessIn the abstractAdiponectin Regulation in Type 2 Diabetic Rats: Effects of Insulin, Metformin and DexamethasoneTamer Ahmed Ismail, Mohamed Mohamed Soliman, Shimaa Ahmed IsmailAdiponectin is a protein synthesized from adipose tissue, increases peripheral glucose utilization in liver and skeletal muscle. Adiponectin expression and secretion are decreased during obesity and insulin resistance. In this study, the effect of insulin, metformin and dexamethasone on serum lipid profiles was examined in Type 2 Diabetic (T2D) rats. T2D was induced by feeding rats a high fat diet … …American Journal of Pharmacology and Toxicology, Vol. 8, Issue 4 · 23 Nov 2013 · 7,723 accessesView PDF Cite

Research ArticleOpen accessIn the abstractBioinformatics Analysis of Some Functional Genes and Proteins Involved in Obesity-Induced Type 2 DiabetesEhab M. Abdella, Rasha R. Ahmed, Mohamed B. Ashour et al.The incidence of type-2 diabetes is rising rapidly worldwide, mainly because of the increase in the incidence of obesity, which is an important risk factor for this condition. Both obesity and type-2 diabetes are complex genetic traits but they also share some nongenetic risk factors. Differences among individuals in their susceptibility to both these conditions probably reflect their genetic constitutions. … …Current Research in Bioinformatics, Vol. 1, Issue 2 · 6 May 2013 · 12,601 accessesView PDF Cite

Research ArticleOpen accessIn the abstractEfficient Anaerobic Fermentation of Simple Sugars by Yeast Fuels Resistance Candida spp. Infections to Eradication by DrugsNedosa Ikenna Valentine, Utoh-Nedosa Uchechukwu Anastasia, Dan Danjuma et al.Problem statement: Human systemic Candida infections had proved difficult to eradicate by the medical health care system. Some practitioners and scholars see the problem as being due to drug resistance. For example an author wrote that ‘secondary drug resistance is clearly being encountered in one setting, oropharyngeal candidiasis in patients with advanced Human Immunodeficiency Virus type 1 (HIV-1) infection usually … …American Journal of Infectious Diseases, Vol. 7, Issue 4 · 10 Dec 2011 · 7,836 accessesView PDF Cite

Research ArticleOpen accessIn the abstractThe Sintering Temperature Effect on the Shrinkage Behavior of Cobalt Chromium AlloyM. Ghazali Kamardan, N. Hidayah A. Zaidi, M. Noh Dalimin et al.Problem Statement: Co-Cr based alloys which is well known for its high Young’s modulus, fatigue strength, wear resistance and corrosion resistance is an important metallic bio-material. However, till date there are only two type of Co-Cr alloy which are the castable and wrought cobalt alloy. Powder Metallurgy route for cobalt is expected to give better result of Co-Cr alloy. The … …American Journal of Applied Sciences, Vol. 7, Issue 11 · 8 Nov 2010 · 7,792 accessesView PDF Cite

Research ArticleOpen accessIn the abstractAnalysis of Resistance to Human Immunodeficiency Virus Protease Inhibitors Using Molecular Mechanics and Machine Learning StrategiesA. Harishchander, D. Alex Anand, Sanjib SenapatiProblem statement: Drug resistance is the most important factor, which influences the failure of current HIV therapies. So, the ability to predict the drug resistance of HIV-1 protease mutants will be useful in developing more effective and longer lasting treatment regimens. Approach: Drug resistance of HIV-1 protease is predicted with two current protease inhibitors (Indinavir and Saquinavir). The problem was … …Current Research in Medicine, Vol. 1, Issue 2 · 31 Oct 2010 · 7,204 accessesView PDF Cite