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33 articles for “Therapeutics”
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Research ArticleOpen accessIn the abstractReverse Pharmacology-A Paradigm Shift for Drug Discovery and DevelopmentAshok D.B. VaidyaThe current scenario of drug discovery and development is facing a model perturbation, despite significant advances in genomics, proteomics, metabolomics, combinatorial chemistry and high through put assays. There is an urgent need of a paradigm shift in approaches to drug discovery. Natural products of Ayurveda offer a vast potential for novel phytomolecules with clinical activity. In India, Ayurveda is availed … …Current Research in Drug Discovery, Vol. 1, Issue 2 · 26 Jan 2015 · 15,404 accessesView PDFCite
EditorialOpen accessIn the abstractAre Heat Shock Proteins Druggable Candidates?Tawanda Zininga, Addmore ShonhaiBanumathy, G., V. Singh, S.R. Pavithra and U. Tatu, 2003. Heat shock protein 90 function is essential for Plasmodium falciparum growth in human erythrocytes. J. Biol. Chem., 278: 18336-18345. DOI: 10.1074/jbc.M211309200 Brehmer, D., S. Rudiger, C.S. Gassler, D. Klostermeier and L. Packschies et al., 2001. Tuning of chaperone activity of Hsp70 proteins by modulation of nucleotide exchange. Nature Structural Molecular … …American Journal of Biochemistry and Biotechnology, Vol. 10, Issue 4 · 2 Dec 2014 · 8,171 accessesView PDFCite
Research ArticleOpen accessIn the abstractTHE IMPACT OF ANTIOXIDANTS ON INFLAMMATION AND OXIDATIVE STRESS MARKERS IN OSTEOARTHRITIS RAT MODEL: SCANNING ELECTRON MICROSCOPE INSIGHTSEl Hassan Heidar, FareedF Al Faya, Waleed N. Hassan et al.Osteoarthritis (OA) is characterized by degradation of matrix and destruction of articular cartilage. Articular chondrocytes are solely responsible for the production and maintenance of the extracellular matrix. Therefore, chondrocyte disruption is implicated in cartilage degeneration. Numerous studies have shown that antioxidant treatments are promising therapeutics in cases of OA. This study was designedto examine whether vitamin E protects rat articular … …American Journal of Pharmacology and Toxicology, Vol. 9, Issue 2 · 19 May 2014 · 7,620 accessesView PDFCite
Research ArticleOpen accessIn the abstractCELL DETACHMENT BY PROLYL-SPECIFIC ENDOPEPTIDASE FROM WOLFIPORIA COCOSNicole Mika, Katharina Cierpka, Michaela C. Lange et al.As requirements for Advanced Therapy Medicinal Product (ATMP) production differ from other production processes (e.g., therapeutic protein production), cell detachment is often a crucial step for the process success. In most cases, cell detachment is done enzymatically. Although many peptidases are established in cell culture in R&D, e.g., Trypsin as gold standard, many of them seem to be unsuitable in … …American Journal of Biochemistry and Biotechnology, Vol. 10, Issue 1 · 8 Feb 2014 · 8,159 accessesView PDFCite
Research ArticleOpen accessIn the abstractREMEDIAL EFFECTS OF VITAMIN E AND L-ARGININE ON PERIPHERAL NEUROPATHY IN STREPTOZOTOCIN-INDUCED DIABETIC RATSIsmaeel Bin-Jaliah, Samah El-Attar, Eman F. Khaleel et al.It was shown that hyperglycemia in diabetic patients is the main factor of diabetic peripheral neuropathies. Various pathways related to oxidative stress, vascular defect and defective endothelium dependent relaxation have been implicated in the development of diabetic peripheral neuropathy. A substantial number of studies have shown that antioxidant treatment are promising therapeutics that can prevent or correct reduced motor nerve … …American Journal of Pharmacology and Toxicology, Vol. 9, Issue 1 · 23 Dec 2013 · 8,044 accessesView PDFCite
Research ArticleOpen accessIn the abstractBiomarker Quantitation: Analytical Considerations for Ligand Binding Assay Regression Curves and Quality Control SamplesMark DysingerAs biomarkers grow in relevance for both the design and support of therapeutics and the clinical trials associated with them, there is an ever increasing need for accurate quantitation of these biochemical entities in biological matrices. While quantifying many biotherapeutics via ligand binding assay platforms can be fairly straightforward, biomarkers present some unique challenges that must be taken into account … …American Journal of Immunology, Vol. 8, Issue 3 · 25 Aug 2012 · 8,030 accessesView PDFCite
Research ArticleOpen accessIn the abstractCoscinium Fenestratum Protects Against Ethanol-Induced Neurodegeneration in Adult Rat BrainWathita Phachonpai, Jintanaporn Wattanathorn, Panakaporn Wannanon et al.Alcoholism is a serious problem throughout the world. Despite intensive efforts to develop novel therapeutics for strategy efficacy against neuronal loss leading to memory impairment in alcoholism is still limited. In view of the pitfalls of psychological dependence and adverse behavioral effects of synthetic drugs, the development of low toxicity and high efficiency medicines derived from natural herbal antioxidants exhibits … …American Journal of Pharmacology and Toxicology, Vol. 7, Issue 3 · 16 Aug 2012 · 8,607 accessesView PDFCite
Research ArticleOpen accessIn the abstractInterplay of Cytokines and Chemokines in the Pathogenesis of Systemic Lupus ErythematosusDilip Shah, Ajay Wanchu, Archana BhatnagarProblem statement: Dysbalance of T-helper-cell (Th) cytokines and chemokines was suggested to contribute to the pathogenesis of Systemic Lupus Erythematosus (SLE). Recent reports suggest the involvement of cytokines and chemokines in the pathogenesis of SLE, but their relationship with each other and particularly in the severity of disease, was not yet understood. We analyzed the interaction between cytokines and chemokines … …American Journal of Immunology, Vol. 7, Issue 3 · 21 Dec 2011 · 8,164 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffect of Phenylbutazone on Pentylenetetrazole-Induced Seizure in MiceKhayatnouri MirhadiProblem statement: The Cyclooxygenases (COXs), the key enzymes that convert arachidonic acid to Prostaglandins (PGs), had been implicated in physiological and pathophysiological functions in the CNS. Non-Stesoidal Anti-Inflammatory Drugs (NSAIDs), COX inhibitors, were used largely to treat febrile condition, pain state and for prevention of and therapeutics of many diseases. However the role of PGs and NSAIDs in the seizure … …American Journal of Animal and Veterinary Sciences, Vol. 6, Issue 4 · 13 Dec 2011 · 7,678 accessesView PDFCite
Research ArticleOpen accessIn the abstractBioautography Guided Identification of Anticandidal Compounds from A. terreus st. 1B. K. Nagaraja, R. Sripathy, C. N. Ramchand, M. SundararamanProblem statement: Saprophytic and soil inhabiting microorganisms are prolific producers of secondary metabolites with wide range of structural and functional diversity. The objective of the current study was to screen and evaluate the anti-candidal properties of soil inhabiting fungi. Approach: Preliminary dual culture assay and bioautography was used to screen the fungi with potential anti-fungal activity and direct detection of … …American Journal of Infectious Diseases, Vol. 7, Issue 4 · 1 Dec 2011 · 7,632 accessesView PDFCite