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32 results for “Therapeutic Strategies”
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Research ArticleOpen accessIn the abstractScreening Neuropharmacological Activities of Kaempferia parviflora (Krachai Dam) in Healthy Adult Male RatsThaneeya Hawiset, Supaporn Muchimapura, Jintanaporn Wattanathorn, Bungorn SripanidkulchaiProblem statement: Although the global prevalence of psychological disorders is increasing continually, the efficacies of therapeutic strategies are still very limited. Oxidative stress has been implicated in the pathogenesis of psychiatric disorders and substance possessing antioxidant activity can alleviate the mentioned conditions. Therefore, we hypothesized that Kaempferia parviflora, a medicinal plant claimed for nerve tonic, also possessed the neuropharmacological activities … …American Journal of Applied Sciences, Vol. 8, Issue 7 · 24 Jun 2011 · 8,697 accessesView PDFCite
Review ArticleOpen accessIn the abstractApproaches for Conservation of an Ethnomedicinal Plant: Asparagus racemosus Willd.Shubha Thakur, Kishan Lal Tiwari, Shailesh Kumar JadhavIndia is one of the megadiversity regions over the globe, gifted with the immense forest resources having the richness of the medicinal plants. The increasing demand of herbal medicines has led to destructive harvesting practices hampering the existence of natural population. Asparagus racemosus, a female-friendly herb, is one such asset to Indian flora having numerous pharmacological applications. Steroidal saponins are … …OnLine Journal of Biological Sciences, Vol. 15, Issue 3 · 12 Jul 2015 · 7,309 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Participation of Oxidative Stress in Breast Cancer Cells Progression and Treatment ResistancePoliana Camila Marinello, Kaliana Larissa Machado, Rubens Cecchini, Alessandra Lourenço CecchiniThis article presents a general discussion about the participation of oxidative stress in relevant points related to breast cancer progression in vitro. All of the evidences presented here are based on published papers that used breast cancer cells with different phenotype characteristics in their research. We observed that oxidative stress could modulate by several manners the tumor progression and these … …American Journal of Immunology, Vol. 10, Issue 4 · 17 Jan 2015 · 7,511 accessesView PDFCite
Research ArticleOpen accessIn the abstractFrom Humans to Dogs and Back: The Translational Lesson of Metronomic ChemotherapyAlessio Pierini, Guido Bocci, Mario Giorgi et al.The main priority in veterinary oncology is to maintain patient quality of life. It is important that new chemotherapy strategies aim to minimize side effects, thus making the treatment attractive for owners as well as their pets. Metronomic chemotherapy has been shown to have an important stabilizing effect on human cancer (including chemotherapy-resistant disease) resulting in prolonged clinical benefit. In … …American Journal of Animal and Veterinary Sciences, Vol. 7, Issue 4 · 31 Dec 2012 · 7,738 accessesView PDFCite
Research ArticleOpen accessIn the abstractCo-Inhibitory Molecule Programmed Death-1 and its Ligands: A New Alternative Therapy for Human Immunodeficiency Virus Infection?A. Leon-Flores, P. Del Rio, G. Reyes-TeranChronic viral infections are characterized by the up-regulation of a set of immunomodulatory receptors. The over-expression of co-inhibitory molecules on T cells leads to a dysfunctional T cell response with an "exhausted" phenotype. Programmed Death-1 (PD-1) is a molecule that exerts an inhibitory signal on the T cell receptor when it binds to the PD-L1 or PD-L2 ligands present on … …American Journal of Infectious Diseases, Vol. 8, Issue 4 · 28 Dec 2012 · 6,962 accessesView PDFCite
Research ArticleOpen accessIn the abstractPlatelets, Coagulation and Cancer: Multifaceted InteractionsT. Burnouf, H. A. GoubranApproach: Literature review of the multifaceted interactions between platelets, coagulation and cancer. Results: Over the years, the links existing between cancer development, progression and occurrence of metastasis on one side and coagulation on the other have become obvious. Tumors seems to activate platelets whereas, platelets, on the other hand, through their capacity to activate and release soluble factors and microparticles, … …Current Research in Medicine, Vol. 3, Issue 2 · 30 Jul 2012 · 7,613 accessesView PDFCite
Research ArticleOpen accessIn the abstractQuercetin Liposomes via Nasal Administration Reduce Anxiety and Depression-Like Behaviors and Enhance Cognitive Performances in RatsTerdthai Tong-Un, Panakaporn Wannanon, Jintanaporn Wattanathorn, Wathita PhachonpaiProblem statement: At present, the prevalence of neuropsychological disorders particularly anxiety, depression and dementia are increase. Many strategies have been developed in order to increase the efficiency of treatment and decrease side effects. Oxidative stress has been reported to play an important role on various path physiological states. Quercetin is a flavonoid commonly found in fruits and vegetables. It has … …American Journal of Pharmacology and Toxicology, Vol. 5, Issue 2 · 30 Jun 2010 · 9,034 accessesView PDFCite
Research ArticleOpen accessIn the abstractPorcine Brain Extract Attenuates Memory Impairments Induced by Focal Cerebral IschemiaJinatta Jittiwat, Jintanaporn Wattanathorn, Terdthai Tongun et al.Problem statement: Stroke or cerebral ischemia has been recognized as one important problem worldwide. To date, the effectiveness of protective and therapeutic strategies against stroke is still very limited. Therefore, the development of novel strategy is required. Porcine brain is traditional believed to improve brain functions. Recent studies showed that the extract of porcine brain could protect against brain damage … …American Journal of Applied Sciences, Vol. 6, Issue 9 · 30 Sep 2009 · 14,615 accessesView PDFCite
Research ArticleOpen accessIn the abstractUltrastructural and Immunological Characterization of Hepatitis C Core Protein-DNA Plasmid ComplexesNelson Acosta-Rivero, Yaraima Aguilera, Viviana Falcon et al.Recently, it has been shown that a truncated HCV core (HCcAg) variant, covering the first 120 aa (HCcAg.120), interacts with plasmid DNA vaccine (pIDKE2), encoding the HCV structural proteins (HCcAg, E1 and E2). In the present work, HCcAg.120-pIDKE2 complexes, forming heterogeneous packaged structures, were visualized using a negative stain/rotary shadow technique. Interestingly, 72 hours after intramuscular injection of HCcAg.120-pIDKE2 complexes … …American Journal of Immunology, Vol. 2, Issue 3 · 30 Sep 2006 · 6,743 accessesView PDFCite