Research ArticleOpen accessIn the abstractPharmacophore Pattern Identification of Tachykinin Receptor Selective Peptide Agonists: Implications in Receptor SelectivityAnjali Dike, Indu R. Chandrashekaran, Anil K. Mantha et al.The mammalian tachykinin (TK) peptides and their three Neurokinin (NK1, NK2 and NK3) receptors represent an effector system with wide-ranging actions on neuronal, airway smooth muscle, mucosal, endothelial, immune, inflammatory and remodeling cell function. Recent clinical and preclinical data suggests the pathophysiological role of TKs in various diseases including asthma, emesis and depression. The TK-NK receptor interactions and overlapping functions … …American Journal of Biochemistry and Biotechnology, Vol. 3, Issue 4 · 31 Dec 2007 · 6,691 accessesView PDFCite
Research ArticleOpen accessIn the abstractIntrinsically Unstructured Proteins: Potential Targets for Drug DiscoveryPathan Salma, Chintan Chhatbar, Sriram SeshadriProblem statement: The function of a protein is dependent on its three-dimensional structure. However, numerous proteins lacking intrinsic globular 3D structure under physiological conditions had been recognized. These proteins are frequently involved in some of the most critical cellular control mechanisms and it appears that their rapid turnover, aided by their unstructured nature in the unbound state, provides a level … …American Journal of Infectious Diseases, Vol. 5, Issue 2 · 30 Jun 2009 · 7,578 accessesView PDFCite
Research ArticleOpen accessIn the abstractRetinoids and Opioids: Factors in the Development of HIV-Related Neurological DiseaseWalter Royal, III, Joseph L. BryantNeurological disease occurs frequently in HIV-infected individuals and may occur at even higher rates among infected drug users. Among the potential mechanisms that promote such impairment, retinoid deficiency may have selective effects that could both lead to alterations in immune function and enhanced replication of HIV. Studies are currently underway to examine the possible selective effects of retinoid receptor activation … …American Journal of Infectious Diseases, Vol. 4, Issue 2 · 30 Jun 2008 · 6,764 accessesView PDFCite
Research ArticleOpen accessIn the abstractElucidating the Mechanism(s) of Hormesis at the Cellular Level: The Universal Cell ResponsePaul S. AgutterMany environmental stressors elicit biphasic effects from single cells. Such cellular hormesis may be interpreted in terms of (a) the superimposition of simple biochemical processes or (b) the non-specific behaviour of the cell. The latter approach is emphasized in this article and identified with the universal cell response (UCR); however, the importance of identifying molecular-level concomitants of the UCR is … …American Journal of Pharmacology and Toxicology, Vol. 3, Issue 1 · 31 Mar 2008 · 13,112 accessesView PDFCite
Research ArticleOpen accessAll words, across the recordInteraction of γ Aminobutyric Acid B Receptors and Electromagnetic Field in the Fear ResponseM. Taherianfard, A. Bahaodini, M. Fazeli, S. Karimi HaghighiOne of the most neurotransmission system consistently linked with fear response is GABAergic system. GABA through GABAB receptor can influence fear response. The aim of the present investigation was to examine the effect of IP injection of baclofen (GABAB agonist) and CGP35348 (GABAB antagonist) along with EMF exposure on frequency of fear response. Fifty adult male rats weighing 180-200 g … …Neuroscience International, Vol. 4, Issue 2 · 1 Apr 2014 · 6,691 accessesView PDFCite