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192 results for “Pathway”
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Research ArticleOpen accessEvery word in the titleDihydroartemisinin Attenuates HBV-Induced Proliferation and Migration in LO2 cells via EMT Pathway ModulationYingde Nong, Caifang Ma, Wei Huang et al.Dihydroartemisinin (DHA), a derivative of artemisinin, possesses well-documented anti-inflammatory properties. This study investigated the inhibitory effects of DHA on hepatitis B virus (HBV)-induced cellular alterations in LO2 cells and elucidated underlying molecular mechanisms. Serum interleukin-6 (IL-6) levels were measured in HBV patients and analyzed for correlations with HBsAg, anti-HBs, and HBeAg. In vitro, LO2 cells were infected with clinical HBV … …American Journal of Biochemistry and Biotechnology, Vol. 21, Issue 3 · 8 Jan 2026 · 2,071 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleNuclear Factor Erythroid-2-Related Factor 2 (Nrf2) Signalling Pathway and Apoptosis Impact on the Effect of Tetramethylpyrazine against H2O2-Damage in Human Hepatic Cell Line (LO2 Cells)Songbo Guo, Xinglin Han, Baoguo Sun et al.As an active component in traditional Chineseherbal medicine, Tetramethylpyrazine (TMP)played a critical role in the treatment of cardiovascular, cerebrovascular, andeye diseases. In this study, the TMP has obtained from the Chinese herbalmedicine Ligusticum chuanxiong and investigated the protective effects of TMPon oxidative damage in human LO2 cells with the treatment ofdifferent concentrations of TMP. The results showed that TMP reserved … …American Journal of Biochemistry and Biotechnology, Vol. 18, Issue 3 · 6 Sep 2022 · 5,654 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleThe Arid3a Transcription Factor Rescues Natural and RAS-V12-Induced Senescence Via a Rb-Dependent PathwayChristian Schmidt, Dongkyoon Kim, Shawn Mathur et al.Primary cells are protected against oncogenic events by undergoing premature cellular senescence—an irreversible cell cycle arrest activated by mitogenic signaling as well as by overexpression of tumor suppressors, including p16INK4A, p53 and PML. In the human, downregulation of Dril1/E2F-BP1, a transcriptional regulator of E2F, promotes PML-dependent premature senescence and bypass of ant-iproliferative signaling by p19Arf/p53/p21Cip1 and p16INK4a to prevent both … …American Journal of Immunology, Vol. 13, Issue 4 · 4 Nov 2017 · 8,396 accessesView PDFCite
Literature ReviewOpen accessEvery word in the titleOmission of Men from Gender-Development Theory and Praxis: A Pathway for Addressing the Plights of Women?Thomas Yeboah, Richard Serbeh, Peter BembirWithin the gender-development discourse, there have been widespread concerns in relation to the neglect of women in benefitting from the process and outcomes of development. This has led in part to the proliferation of policy programming designed for women to achieve gender equality while ensuring that women benefit proportionally from development. However the extent to which gender-based interventions will succeed … …Journal of Social Sciences, Vol. 11, Issue 1 · 25 Apr 2015 · 7,783 accessesView PDFCite
Review ArticleOpen accessEvery word in the titleUnveiling the Factors Influencing Social Media Usage Among A'Sharqiyah University Students: Exploring Impacts and Pathways to OptimizationHamed Al Hajri, Salim Al Hajri, Alycia SebastianSocial media networks facilitate global connectivity and communication by providing platforms for users to interact, share information, and build communities online. This study aims to explore the impact of utilizing Social Media Networks (SMNs) on the academic attainment of A’Sharqiyah University students in the Sultanate of Oman. It recognizes the global significance of SMNs in modern society, emphasizing their role … …Journal of Computer Science, Vol. 20, Issue 11 · 5 Sep 2024 · 4,867 accessesView PDFCite
Research ArticleOpen accessIn the keywordsFabrication of Polysaccharides from a Fermented Tea and Their Antioxidant and Hypoglycemic ViabilityJun Li, Lingxian Tong, Bing Li et al.The hypoglycemic effects of tea have been extensively studied, with fermented tea demonstrating notable efficacy owing to its distinct processing methods. This study involved the extraction of tea polysaccharides from Wuniuzao Black Tea (WTP) using a water extraction and ethanol precipitation method. WTP-1 and WTP-2 were obtained by separation and purification using DEAE-52 cellulose columns. Antioxidant activity was evaluated utilizing … …American Journal of Biochemistry and Biotechnology, Vol. 22, Issue 2 · 30 Jul 2026 · 655 accessesView PDFCite
Research ArticleOpen accessIn the keywordsUPLC-QTOF-MS/MS and Bioinformatics Association Analysis Reveals the Pharmacodynamic Flavonoids in Scutellaria barbata and the Underlying Anti-Colorectal Cancer MechanismYi-Jie Cheng, Xin-Yun Du et al.Colorectal Cancer (CRC) is one of the most common and deadly malignancies worldwide, with no safe and effective drugs. The flavonoid in Scutellaria Barbata D. Don (SB) showed a good therapeutic effect on CRC. However, the pharmacodynamic substances and underlying mechanisms have not been elucidated which limited its development and application. This study aimed to identify the main flavonoid in … …American Journal of Biochemistry and Biotechnology, Vol. 19, Issue 4 · 14 Nov 2023 · 5,398 accessesView PDFCite
Research ArticleOpen accessIn the keywordsAnaerobic Fermentation for Ceftriaxone Sodium Degradation in Excess Sludge: pH-Dependent Performance, Metabolite Formation, and Microbial Community DynamicsWeiwei Li, Hong Niu, Yonghui Zhang et al.The accumulation of ceftriaxone sodium (CTX), a third-generation cephalosporin antibiotic, in wastewater and sludge poses significant environmental and health risks, necessitating effective degradation strategies. This study investigated anaerobic fermentation of excess sludge (12,000-14,000 mg/L) spiked with 15 mg/L CTX under varying pH conditions (4, 7, 10, 12) to evaluate sludge reduction, metabolite formation, and microbial community dynamics. Results demonstrated that … …American Journal of Biochemistry and Biotechnology, Vol. 22, Issue 2 · 31 Jul 2026 · 857 accessesView PDFCite
Research ArticleOpen accessIn the keywordsIntegrated Monitoring of Endocrine-Disrupting Chemicals: Analytical Chemistry and Biological Assessment ApproachesChangjin Li, Jing Huo, Zijun Dou et al.Endocrine-Disrupting Chemicals (EDCs) in aquatic environments pose significant threats to ecosystems and human health. These compounds interfere with hormonal regulation at low concentrations and have non-monotonic dose-response relationships, posing challenges to conventional risk assessment. This review systematically compares current EDC monitoring methods, including instrumental chemical analysis and receptor-based biological detection systems, to evaluate sensitivity thresholds, sample throughput, and mechanistic selectivity … …American Journal of Biochemistry and Biotechnology, Vol. 22, Issue 2 · 3 Jul 2026 · 1,081 accessesView PDFCite
Research ArticleOpen accessIn the keywordsEffects of Nitrogen Source on the Lipid Accumulation in Phaeodactylum TricornutumXiaojie Ren, Qi Yan, Song Li et al.Nitrogen source has an important influence on the growth and lipid synthesis of Phaeodactylum tricornutum. It affects lipid accumulation through global metabolic regulation. However, little research has been done on the correlation between other metabolites and lipid metabolism during the synthesis of Phaeodactylum tricornutum. In this study, we studied the effect of different nitrogen sources on lipid and other major … …American Journal of Biochemistry and Biotechnology, Vol. 16, Issue 3 · 27 Jul 2020 · 6,913 accessesView PDFCite