25 articles for “Neuroprotective Effect”

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Research ArticleOpen accessIn the abstractMulberry Fruit Mitigates Alcohol Neurotoxicity and Memory Impairment Induced by Chronic Alcohol IntakeJintanaporn Wattanathorn, Nattaporn Phunchago, Supaporn Muchimapura et al.Problem statement: To date, the therapeutic strategy efficacy against memory impairment induced by alcohol intoxication is still limited. The novel therapeutic strategy which is easy to approach, less toxic and less cost is required. Based on the role of oxidative stress in memory impairment induced by alcohol, the neuroprotective effect of substance possessing antioxidant has gained much attention. Therefore, we … …American Journal of Applied Sciences, Vol. 9, Issue 4 · 8 Feb 2012 · 9,328 accessesView PDF Cite

Research ArticleOpen accessIn the abstractRandomized Clinical Stroke Trials in 2009Meheroz H. RabadiProblem statement: Stroke ranks as the leading cause of serious, long-term disability and death world-wide. It is estimated direct and indirect cost of stroke for 2009 was $68.9 billion. Approach: The objective of this review was to examine the effectiveness of emerging pharmacotherapy’s in patients with acute (≤2 weeks), sub-acute (2-12 weeks) and chronic (≥12 weeks) stroke studied in Randomized … …Current Research in Medicine, Vol. 1, Issue 1 · 30 Jun 2010 · 7,243 accessesView PDF Cite

Research ArticleOpen accessIn the abstractProduction and Roles of Glial Tissue Inhibitor of Metalloproteinases-1 in Human Immunodeficiency Virus-1-Associated Dementia Neuroinflammation: A ReviewC. Chao, A. GhorpadeProblem statement: Tissue Inhibitor of Metalloproteinases-1 (TIMP-1) and its cognate targets, the Matrix Metalloproteinases (MMPs), were differentially expressed in human brain samples with or without HIV-1 infection or HIV-1 Encephalitis (HIVE). Approach: A through literature review demonstrated that cell culture models of Central Nervous System (CNS) cell types had been used to illustrate the intricate temporal patterns of TIMP-1/MMP expression, … …American Journal of Infectious Diseases, Vol. 5, Issue 4 · 31 Dec 2009 · 6,953 accessesView PDF Cite

Research ArticleOpen accessIn the abstractPorcine Brain Extract Attenuates Memory Impairments Induced by Focal Cerebral IschemiaJinatta Jittiwat, Jintanaporn Wattanathorn, Terdthai Tongun et al.Problem statement: Stroke or cerebral ischemia has been recognized as one important problem worldwide. To date, the effectiveness of protective and therapeutic strategies against stroke is still very limited. Therefore, the development of novel strategy is required. Porcine brain is traditional believed to improve brain functions. Recent studies showed that the extract of porcine brain could protect against brain damage … …American Journal of Applied Sciences, Vol. 6, Issue 9 · 30 Sep 2009 · 14,615 accessesView PDF Cite

Research ArticleOpen accessIn the abstractNeuroprotection Afforded by GABA Against Oxygen-Glucose Deprivation-Induced Injury in Rat Cortical Brain Slices: An Hormetic Dose-Response EffectLorenzo Ricci, Massimo Valoti, Giampietro Sgaragli, Maria FrosiniThe aim of the present investigation was to assess neuroprotection exerted by GABA (100 nM-100 mM) in rat cortical brain slices subjected to oxygen-glucose deprivation and reoxygenation. Neuronal injury and neuroprotection were assessed by measuring the release of glutamate and lactate dehydrogenase and tissue water content. Results demonstrate that GABA exerted neuroprotective effects according to a U-shaped, hormetic-like, concentration-response curve, … …American Journal of Pharmacology and Toxicology, Vol. 3, Issue 1 · 31 Mar 2008 · 7,166 accessesView PDF Cite