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65 articles for “Mechanism of Action”
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Research ArticleOpen accessIn the abstractDynamics of Buses - Part IIRelly Victoria Virgil Petrescu, Raffaella Aversa, Gheorghe Frătilă et al.Dynamics, or dynamic processes, is the part of mechanics dealing with the study of processes trying to describe as real as possible the movement of a body, element, mechanism, car, etc., also taking into account the action of the forces on the respective system with their influence on the actual movement of system. The present paper aims to present the … …American Journal of Engineering and Applied Sciences, Vol. 11, Issue 2 · 20 Apr 2018 · 8,001 accessesView PDFCite
Research ArticleOpen accessIn the abstractDynamics of Buses - Part IRelly Victoria Virgil Petrescu, Raffaella Aversa, Gheorghe Frăţilă et al.Dynamics, or dynamic processes, is the part of mechanics dealing with the study of processes trying to describe as real as possible the movement of a body, element, mechanism, car, etc., also taking into account the action of the forces on the respective system with their influence on the actual movement of system. The present paper aims to present the … …American Journal of Engineering and Applied Sciences, Vol. 11, Issue 2 · 20 Apr 2018 · 8,314 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Effect of Bovine Cartilage on the Growth of Mouse B16F10 Melanoma Cells in vitro and in vivoArax Tanelian, Dalal F. Jaber, Nayla S. Al Akl, Alexander M. AbdelnoorEarlier reports indicated that Bovine Cartilage (BC) had anti-tumor effects but only a few in vitro and in vivo investigations were conducted to assess its mechanism of action. The aim of this study was to investigate some of the proposed mechanisms of action of BC on mouse melanoma cells both in vitro and in vivo and to determine if its … …American Journal of Immunology, Vol. 12, Issue 3 · 26 Oct 2016 · 7,489 accessesView PDFCite
Research ArticleOpen accessIn the abstractBinding Mechanism of Bovine Serum Albumin to Troxerutin by Synchronous Fluorescence Spectroscopy and ChemometricsTianhu Wang, Yi Yan, Yinsheng LuoPrevious works have reported the binding of Bovine Serum Albumin (BSA) to troxerutin by absorption and fluorescence spectroscopy. In order to extend the investigation of their binding characteristics, the study presented here was designed to evaluate their interaction by the synchronous fluorescence spectroscopy and Multivariate Curve Resolution With Alternating Least Squares (MCR-ALS) under simulative physiological conditions. The Evolving Factor Analysis … …American Journal of Biochemistry and Biotechnology, Vol. 12, Issue 2 · 14 May 2016 · 7,449 accessesView PDFCite
EditorialOpen accessIn the abstractImpact of Quantitative Pharmacology on Drug DevelopmentAna Ruiz-Garcia, Kourosh ParivarThesuccess of drug development rests over two well defined pillars, a goodunderstanding of the drug’s clinical pharmacology and the appropriate targetpopulation for whom the clinical use is intended. The label for human prescription drugsrequires a good understanding of the pharmacological effects (pharmacodynamicsor PD) and the mechanism of action of the drug as well as detailed informationof the drug’s Pharmacokinetics (PK): … …American Journal of Pharmacology and Toxicology, Vol. 9, Issue 4 · 24 Apr 2015 · 7,158 accessesView PDFCite
Research ArticleOpen accessIn the abstractResearch Proposal: An Intrusion Detection System Alert Reduction and Assessment Framework Based on Data MiningKarim Al-Saedi, Selvakumar Manickam, Sureswaran Ramadass et al.The Intrusion Detection System (IDS) generates huge amounts of alerts that are mostly false positives. The abundance of false positive alerts makes it difficult for the security analyst to identify successful attacks and to take remedial actions. Such alerts to have not been classified in accordance with their degree of threats. They further need to be processed to ascertain the … …Journal of Computer Science, Vol. 9, Issue 4 · 8 May 2013 · 7,709 accessesView PDFCite
Research ArticleOpen accessIn the abstractStem Cells in Traumatic Brain InjurySamuel Dobrowolski, Guilherme LepskiTraumatic Brain Injury (TBI) is a devastating clinical condition that often causes permanent incapacity, especially in the younger population. The clinical relevant of TBI justifies the scientific interest in the pathophysiology of TBI, as well as in protective effects and development of treatment options. Stem cells have the ability to induce neuroprotection and neural repair inflammatory suppression, causing tissue reconstruction … …Neuroscience International, Vol. 4, Issue 1 · 12 Apr 2013 · 7,564 accessesView PDFCite
Research ArticleOpen accessIn the abstractGastroprotective Effect and Safety Assessment of Zanthoxylum Zanthoxyloides (Lam) Waterm Root Bark ExtractAlex Boye, George Asumeng Koffuor, Johnson Nyarko Boampong et al.Problem statement: Gastrointestinal ulcers account significantly for morbidity and mortality in Ghana. The study therefore investigated the gastroprotective effect of an ethanolic root bark extract of Zanthoxylum zanthxyloides and its safety for us. Approach: Gastric ulceration was induced in Sprague-Dawley rats with Indomethacin (25 mg kg-1, p.o) and was treated with 150, 250, or 500 mg kg-1 of the extract, … …American Journal of Pharmacology and Toxicology, Vol. 7, Issue 2 · 7 Aug 2012 · 8,495 accessesView PDFCite
Research ArticleOpen accessIn the abstractTramadol Vs Tapentadol: Anew Horizon in Pain Treatment?Mario GiorgiProblem statement: Acute and chronic pain is a common presenting sign in animal species and human beings. Approach: Classical opioids provide very effective pain relief, although they may be less effective in the treatment of chronic pain due to their limited therapeutic windows and the induced opioid receptor down regulation. Atypical opioids, such as tramadol and tapentadol, have a dual … …American Journal of Animal and Veterinary Sciences, Vol. 7, Issue 1 · 25 Feb 2012 · 17,871 accessesView PDFCite
Research ArticleOpen accessIn the abstractMolecular Medicine-Prospects and ChallengesC. N. Ramchand, R. Sripathy, N. Somashekara et al.Drug discovery and development is a process that rationally leads to instigation of compound or formulation for the treatment of particular disease/diseased condition by acting on its specific target (s). Most of the drugs identified by conventional drug discovery process were as a result of unsystematic, random and serendipitous approach. Enhancement of knowledge in the field of biotechnology, molecular biology … …American Journal of Infectious Diseases, Vol. 8, Issue 1 · 23 Feb 2012 · 7,473 accessesView PDFCite