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35 results for “Histopathology”
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Research ArticleOpen accessIn the abstractModeling Hepatocellular Toxicity of Enavatuzumab, a Humanized Anti-TweakR AntibodyDonghee Choi, Yanhong Zhu, Debra Tien Chao et al.In a Phase 1 clinical study, treatment with enavatuzumab, a humanized monoclonal antibody to TweakR, resulted in liver toxicity in a subset of patients. The objective of this current study was to evaluate the ability of preclinical studies to predict liver toxicity in humans. Enavatuzumab was evaluated in cynomolgus monkeys, where serum liver enzyme and cytokine levels were measured and … …American Journal of Pharmacology and Toxicology, Vol. 12, Issue 2 · 9 Nov 2017 · 7,719 accessesView PDFCite
Case ReportOpen accessIn the abstractRhizopus Laryngitis Post Allogenic Stem Cell TransplantationMayank Dhamija, Sanjeev Kumar Sharma, Dharma Choudhary et al.Invasive Fungal Infections (IFI) are an important complication and constitute significantly to mortality and morbidity, post Hematopoietic Stem Cell Transplant (HSCT). We report a very rare case of fungal laryngitis post HSCT in a 15-year-old girl with Thalassemia major. She received Busulphan, Cyclophosphamide and Antithymocyte Globulin (Bu-Cy-ATG) based conditioning pre Matched Sibling Donor (MSD) transplant and presented on day 10 … …American Journal of Infectious Diseases, Vol. 12, Issue 2 · 4 Jun 2016 · 7,325 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffect of Long Term Cadmium Chloride Exposure on Testicular Functions in Male Albino RatsRania Abdel Rahman Elgawish, Mohamed Elshabrawy GhanemThis study was carried out to investigate the adverse effects of different doses of Cadmium Chloride (CdCl2) on reproductive functions in male rats. Forty male albino rats weighted 100-130 g were equally divided into 4 groups. The control group received distilled water throughout the experimental period, while the three treated groups received 5, 50 and 100 ppm of CdCl2 in … …American Journal of Animal and Veterinary Sciences, Vol. 9, Issue 4 · 10 Dec 2014 · 8,302 accessesView PDFCite
Research ArticleOpen accessIn the abstractISOLATION AND DETECTION OF HELICOBACTER PYLORI FROM PATIENTS SUFFERING FROM PEPTIC ULCER USING BIOCHEMICAL TESTS AND MOLECULAR TECHNIQUESRuba S. Abu-Sbeih, Azmi D. Hawari, Dhia S. Hassawi, Hala I. Al-DaghistaniHelicobacter pylori is the causative agent of most cases of gastritis. There is no established gold standard for the diagnosis of H. pylori infection. A reliable diagnosis is crucial to confirm that eradication therapy has been successful. Eighty gastric biopsy and blood samples were obtained from fasting Jordanian patients with Esophago-Gastro-Doudenoscopy (EGD). Several diagnosis tests for H. pylori infections were … …American Journal of Biochemistry and Biotechnology, Vol. 10, Issue 1 · 28 Mar 2014 · 8,183 accessesView PDFCite
Research ArticleOpen accessIn the abstractPRESUMPTIVE REOVIRUS INFECTION IN BROILER BREEDERSF. A. Moreira, M. L. Pinto, L. Cardoso, A. C. CoelhoTenosynovitis is one of the pathological manifestations of avian reovirus infection and are of economic importance, special in one of the most important stages of the poultry industry, i.e., broiler breeders. In late May 2012, an outbreak of unilateral lameness occurred in a broiler breeder flock (15,000 birds divided by two houses) of a multi-age farm, with a total of … …American Journal of Animal and Veterinary Sciences, Vol. 9, Issue 1 · 3 Feb 2014 · 7,004 accessesView PDFCite
Research ArticleOpen accessIn the abstractPOTENTIAL AMELIORATIVE ROLE OF N-ACETYLCYSTEINE AGAINST TESTICULAR DYSFUNCTION INDUCED BY TITANIUM DIOXIDE IN MALE ALBINO RATSAhmed Farag El-Kirdasy, Mohamed Abdo Nassan, Ahmed Abdel Aziz Baiomy et al.In this study, we examined the ameliorative action of N-Acetylcysteine (NAC) against Titanium Dioxide (TiO2) induced testicular degeneration in albino rats. Adult male albino rats were given saline as a control group, TiO2 (1200 mg kg-1 BW), NAC (100 mg kg-1 BW) and co-treatment of NAC and TiO2 as a protective group for 3 months. Testicular tissues were extracted for … …American Journal of Pharmacology and Toxicology, Vol. 9, Issue 1 · 31 Dec 2013 · 7,900 accessesView PDFCite
Research ArticleOpen accessIn the abstractProtective Effect of N-Acetylcystiene Against Titanium Dioxide Nanoparticles Modulated Immune Responses in Male Albino RatsMohamed Mohamed Soliman, Hossam Fouad Attia, Mohamed Mahmoud Hussein et al.The protective effects of N-Acetylcysteine (NAC) against orally administered titanium dioxide nanoparticles (TiO2) for 3 months on male albino rats were examined. Adult male albino rats were given saline as a control group, TiO2 (1200 mg kg-1 BW), NAC (100 mg kg-1 BW) and co-treatment of NAC and TiO2 as a protective group for 3 months. Blood was assayed for … …American Journal of Immunology, Vol. 9, Issue 4 · 30 Nov 2013 · 7,273 accessesView PDFCite
Research ArticleOpen accessIn the abstractHepatoprotective Effect of N-Acetylcystiene on the Toxic Hazards of titanium Dioxide NanoparticlesHossam Fouad Attia, Mohamed Mohamed Soliman, Gamal Hassan Abdel-Rahman et al.The present study was directed to evaluate the toxic effects of orally administered titanium dioxide naonparticles (TiO2) on liver of male albino rats and to evaluate the ameliorative effects of N-acetylcysteine (NAC). Forty adult male albino rats were divided into 4 groups; control group, NAC group, TiO2 group and TiO2/ NAC group. Rats were administered either TiO2 (1200 mg kg-1 … …American Journal of Pharmacology and Toxicology, Vol. 8, Issue 4 · 26 Sep 2013 · 8,133 accessesView PDFCite
Research ArticleOpen accessIn the abstractAqueous Stem Bark Extract of Spathodea campanulata (P. Beauv) Modulates Carbon Tetrachloride Induced Hepatic Damage in RatsCharles Ansah, Phyllis Elsie Dadzeasah, Emmanuel AsiamahThe objective of the present study was to evaluate the hepatoprotective and curative potential of the aqueous extract of the stem bark of Spathodea Campanulata (SCE) in a carbon tetrachloride-induced model of hepatotoxicity in rats. Rats pre-treated with 625 mg kg-1, 1250, 2500 mg kg-1 or silymarin (50 mg kg-1) p.o for 3 days were intoxicated with CCl4 (1 mL … …American Journal of Pharmacology and Toxicology, Vol. 8, Issue 1 · 27 May 2013 · 8,999 accessesView PDFCite
Research ArticleOpen accessIn the abstractACUTE TOXICITY STUDY OF TOMATO POMACE EXTRACT IN RODENTSupaporn Muchimapura, Terdthai Tong-Un, Jintanaporn Wattanathorn et al.Tomato and tomato products are considered to be healthy food for the human diet. Although tomatoes have been widely studied for their phenolic content, less emphasize has been laid on toxicological effect of this plant. Thus, the purpose of the present study is to determine the acute toxicity effect of Lycopersicon esculentum, or commonly known as tomato, was administered orally … …OnLine Journal of Biological Sciences, Vol. 13, Issue 1 · 24 Feb 2013 · 7,683 accessesView PDFCite