Research ArticleOpen accessIn the abstractAnticonvulsant Effect of Pitavastatin in Mice Induced by PentylenetetrazoleKhayatnouri MirhadiProblem statement: The 3-Hydroxy-3-Methylglutaryl-CoA (HMG-CoA) reductase inhibitors (statins) have been unequivocally shown to reduce cardiovascular morbidity and mortality by their lipid-lowering actions. It has been suggested that statins appear to have therapeutic benefits in diseases that are unrelated to elevated serum cholesterol levels. The aim of this study was to evaluation the effect of intraperitoneally injection of different doses of … …American Journal of Animal and Veterinary Sciences, Vol. 6, Issue 4 · 11 Jan 2012 · 7,507 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffect of Phenylbutazone on Pentylenetetrazole-Induced Seizure in MiceKhayatnouri MirhadiProblem statement: The Cyclooxygenases (COXs), the key enzymes that convert arachidonic acid to Prostaglandins (PGs), had been implicated in physiological and pathophysiological functions in the CNS. Non-Stesoidal Anti-Inflammatory Drugs (NSAIDs), COX inhibitors, were used largely to treat febrile condition, pain state and for prevention of and therapeutics of many diseases. However the role of PGs and NSAIDs in the seizure … …American Journal of Animal and Veterinary Sciences, Vol. 6, Issue 4 · 13 Dec 2011 · 7,675 accessesView PDFCite
Research ArticleOpen accessIn the abstractUsing Invariant Translation to Denoise Electroencephalogram SignalsJanett Walters-Williams, Yan LiProblem statement: Because of the distance between the skull and the brain and their different resistivity's, Electroencephalogram (EEG) recordings on a machine is usually mixed with the activities generated within the area called noise. EEG signals have been used to diagnose major brain diseases such as Epilepsy, narcolepsy and dementia. The presence of these noises however can result in misdiagnosis, … …American Journal of Applied Sciences, Vol. 8, Issue 11 · 5 Oct 2011 · 7,508 accessesView PDFCite
Research ArticleOpen accessIn the abstractSwarm Negative Selection Algorithm for Electroencephalogram Signals ClassificationNasser Omer Sahel Ba-Karait, Siti Mariyam Shamsuddin, Rubita SudirmanProblem statement: The process of epilepsy diagnosis from EEG signals by a human scorer is a very time consuming and costly task considering the large number of epileptic patients admitted to the hospitals and the large amount of data needs to be scored. Therefore, there is a strong need to automate this process. Such automated systems must rely on robust … …Journal of Computer Science, Vol. 5, Issue 12 · 31 Dec 2009 · 7,205 accessesView PDFCite
Research ArticleOpen accessIn the abstractOn Application of Carhart Atom Pairs to Predict Anticonvulsant ActivityAlan Talevi, Julian J. Prieto, Luis E. Bruno-Blanch, Eduardo CastroAbout 50 million people in the world suffer from epilepsy, especially in childhood, adolescence and old age. Available treatment fails to control epilepsy in up to 30% of affected people. In developing countries, however, the amount of patients that do not receive adequate treatment climbs up to 75%. Moreover, the new generation of antiepileptic drugs (AEDs) causes important central and … …American Journal of Biochemistry and Biotechnology, Vol. 2, Issue 3 · 30 Sep 2006 · 6,857 accessesView PDFCite