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140 articles for “Drug Problem”
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Research ArticleOpen accessIn the abstractTramadol Vs Tapentadol: Anew Horizon in Pain Treatment?Mario GiorgiProblem statement: Acute and chronic pain is a common presenting sign in animal species and human beings. Approach: Classical opioids provide very effective pain relief, although they may be less effective in the treatment of chronic pain due to their limited therapeutic windows and the induced opioid receptor down regulation. Atypical opioids, such as tramadol and tapentadol, have a dual … …American Journal of Animal and Veterinary Sciences, Vol. 7, Issue 1 · 25 Feb 2012 · 17,871 accessesView PDFCite
Research ArticleOpen accessIn the abstractDevelopment of Curcumin Based Ophthalmic FormulationD. Anjana, K. Anitha Nair, N. Somashekara et al.Problem statement: Ophthalmic drug delivery system has been a major challenge due to the distinctive and unique anatomy of the eye. The use of phytochemicals for the application in ocular disease has not been investigated much, due to poor pharmacokinetics of phytochemical and hence poor therapeutic efficacy. Approach: Curcumin is one such phytochemical known for its medicinal properties, but its … …American Journal of Infectious Diseases, Vol. 8, Issue 1 · 24 Feb 2012 · 15,401 accessesView PDFCite
Research ArticleOpen accessIn the abstractStudy on Survival of Chlamydia trachomatis in the Presence of Antichlamydial DrugsApurb Rashmi Bhengraj, Pragya Srivastava, Harsh Vardhan et al.Problem statement: Recurrent genital Chlamydia trachomatis infections due to treatment failures may results in complex sequelae leading to reproductive complexity and morbidity. It can be resulted by the heterotypic resistance with decreased drug susceptibility characteristic of the isolate. Studies are needed to understand the treatment failures and resistance characteristic of C. trachomatis. Hence, in vitro study was conducted on C. … …American Journal of Infectious Diseases, Vol. 8, Issue 1 · 20 Feb 2012 · 7,768 accessesView PDFCite
Research ArticleOpen accessIn the abstractDistribution, Arrangement and Interconnectedness of Cell Surface Receptor sites in the body of an OrganismUtoh-Nedosa, Uchechukwu AnastasiaCell surface receptors have been identified as the sites of disease infectivity in living organisms in a previous study. Drugs used for the treatment or cure of infections have to eliminate infections through attacking infective organisms at the cell surface receptors to which the infective organisms are attached. Problem statement: The present study examines a wide sample of living things … …OnLine Journal of Biological Sciences, Vol. 11, Issue 4 · 26 Jan 2012 · 7,355 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffect of Saffron on Histomorphometric Changes of Testicular Tissue in RatMirhadi Khayatnouri, Seyed Esmail Safavi, Saied Safarmashaei et al.Problem statement: Saffron is widely used as a food flavor and has well known medicinal effects. This drug has an effect on steroid and sexual hormones. The aim of this study was investigation of Saffron orally administration on histomorphometric change of testicular tissue in rat. In this experimental study, 40 male rats are used (4 groups and 10 rats in … …American Journal of Animal and Veterinary Sciences, Vol. 6, Issue 4 · 11 Jan 2012 · 7,965 accessesView PDFCite
Research ArticleOpen accessIn the abstractInteraction of Aqueous Extract of Trigonella Foenum-Graecum Seeds with Glibenclamide in Streptozotocin Induced Diabetic RatsV. K. Lal, P. P. Gupta, P. Tripathi, A. PandeyProblem statement: Interaction between herbs and drugs may increase or decrease the pharmacological or toxicological effects of either component. Herb traditionally used to decrease glucose concentrations in diabetes could theoretically precipitate hypoglycaemia if taken in combination with conventional drugs. Approach: The present study was undertaken to determine the interaction of Glibenclamide, a Sulphonylurea with Trigonella foenum-graecum seed extract, an herbal … …American Journal of Pharmacology and Toxicology, Vol. 6, Issue 4 · 31 Dec 2011 · 8,016 accessesView PDFCite
Research ArticleOpen accessIn the abstractDrug Susceptibility Pattern of M.Tuberculosis Isolated from Patients Attending a Private HospitalD. Sureshkumar, Ram GopalakrishnanProblem statement: Drug resistance in Tuberculosis (TB) is an emerging problem that adversely affects patient outcome and public health in the developing world. Although much of tuberculosis care is provided by the private sector in India, the magnitude of drug resistance in TB in the private sector is not well described. The present study was carried out to determine the … …American Journal of Infectious Diseases, Vol. 7, Issue 4 · 22 Dec 2011 · 7,281 accessesView PDFCite
Research ArticleOpen accessIn the abstractEfficient Anaerobic Fermentation of Simple Sugars by Yeast Fuels Resistance Candida spp. Infections to Eradication by DrugsNedosa Ikenna Valentine, Utoh-Nedosa Uchechukwu Anastasia, Dan Danjuma et al.Problem statement: Human systemic Candida infections had proved difficult to eradicate by the medical health care system. Some practitioners and scholars see the problem as being due to drug resistance. For example an author wrote that ‘secondary drug resistance is clearly being encountered in one setting, oropharyngeal candidiasis in patients with advanced Human Immunodeficiency Virus type 1 (HIV-1) infection usually … …American Journal of Infectious Diseases, Vol. 7, Issue 4 · 10 Dec 2011 · 7,836 accessesView PDFCite
Research ArticleOpen accessIn the abstractSlow Fungal Hydrolysis of Complex Sugar is Responsible for the Use of Sugar as Vehicle for Antifungal DrugsNedosa Ikenna Valentine, Utoh-Nedosa Uchechukwu Anastasia, Dan Danjuma et al.Problem statement: Aspergillus niger strain (UUF 9202) significantly reduced the dormancy period and boosted aggregate germination time in seeds of Tetrapleura tetraptera by 42% in 32 days and produced a net reduction in mean germination time of the seeds to 12 days. A structure-fungitoxicity relationship study of a series of isoflavonoids against Aspergillus niger and Cladosporium cucumerinum showed that a … …American Journal of Pharmacology and Toxicology, Vol. 6, Issue 3 · 2 Nov 2011 · 7,665 accessesView PDFCite
Research ArticleOpen accessIn the abstractAntibacterial Activity of β-Cyclodextrin and 2-Hydroxypropyl-β-Cyclodextrin Trimethoprim ComplexesHsien-Kuo Sun, Madhumathi Seshadri, Scott Lingard et al.Problem statement: Cyclodextrin complexation has previously been shown to improve the solubility and dissolution properties of trimethoprim; however, no report provides an account of the effect cyclodextrin complexation has on the antibacterial activity of this agent. Approach: β-cyclodextrin and 2-hydroxypropyl β-cyclodextrin inclusion complexes of trimethoprim were prepared and confirmed by differential scanning calorimetry and proton nuclear magnetic resonance. The in-vitro … …Current Research in Microbiology, Vol. 2, Issue 1 · 26 Oct 2011 · 14,801 accessesView PDFCite