26 results for “Deleterious Effect”

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Research ArticleOpen accessIn the abstractEvaluation of the Toxic Effects of Dihydroartemisinin on the Vital Organs of Wistar Albino RatsA. U. Utoh-Nedosa, P. A. Akah, T. C. Okoye, C. O. OkoliProblem statement: The current surge in the use of Artemisinin based Combination Therapy (ACT) in the treatment of falciparium resistant malaria in the tropics and the potentials of Dihydroartemisinin (DHA), a member of the artemisinin family, to produce toxic effect in the vital organs (such as the liver, heart, lungs, intestine, spleen kidney and blood cells) necessitated this research. Approach: … …American Journal of Pharmacology and Toxicology, Vol. 4, Issue 4 · 31 Dec 2009 · 9,181 accessesView PDF Cite

Research ArticleOpen accessIn the abstractA Simulation Model Estimates of the Intercropping Advantage of an Immature-Rubber, Banana and Pineapple SystemMohamadu Boyie Jalloh, Wan Sulaiman Wan Harun, Jamal Talib et al.Problem statement: Intercropping has been shown to have many advantages but it is fallacious to conclude it is always a better cropping system. Little is known about a new double-hedgerow intercropping of rubber, banana and pineapple in relation to its effects on growth and yield of the component crops when compared to their monocrops. Simulation modeling offers a cheaper and … …American Journal of Agricultural and Biological Sciences, Vol. 4, Issue 3 · 30 Sep 2009 · 9,003 accessesView PDF Cite

Research ArticleOpen accessIn the abstractEffects of Leaf Extract of Urtica pilulifera L. on Male Reproductive System of Streptozotocin-Diabetic RatsFawzi Irshaid, Kamal MansiProblem statement: Urtica pilulifera L. (Urticaceae), has long been used for the treatment of various aliments including diabetes. Diabetes is a metabolic disorder characterized by hyperglycemia which has a deleterious effect on all systems including reproductive system of animals. Therefore, the current study was designed to investigate the effects of Urtica pilulifera on the reproductive system of diabetic rats. Approach: … …American Journal of Pharmacology and Toxicology, Vol. 4, Issue 2 · 30 Jun 2009 · 8,554 accessesView PDF Cite

Research ArticleOpen accessIn the abstractKidney Function Indices in Mice after Long Intake of Agaricus brasiliensis Mycelia (=Agaricus blazei, Agaricus subrufescens) Produced by Solid State CultivationDalla Santa Herta Stutz, Rubel Rosália, Vitola Francisco Menino Destéfanis et al.Problem statement: Agaricus brasiliensis (=Agaricus blazei, Agaricus subrufescens) or Sun mushroom has widespread use for potential health benefits such anti-tumor and immunomodulatory effects. Studies detected that others edible mushrooms affected renal metabolism and despite the widespread use of A. brasiliensis there are no studies that address biological effects on the renal function indices after their oral administration. Therefore, this study … …OnLine Journal of Biological Sciences, Vol. 9, Issue 1 · 31 Mar 2009 · 8,149 accessesView PDF Cite

Research ArticleOpen accessIn the abstractThe Role of Neurodevelopmental Genes in Infectious Etiology of AutismS. Hossein FatemiAutism is a neurodevelopmental disorder with both genetic and environmental etiologies. Prenatal infections may play a role in evolution of autism. Experimental evidence shows human influenza viral infection in pregnancy leads to significant deleterious effects in brain structure and function in the developing mouse progeny. Several brain genes of interest in this animal model are also involved in the pathology … …American Journal of Biochemistry and Biotechnology, Vol. 4, Issue 2 · 30 Jun 2008 · 6,563 accessesView PDF Cite

Research ArticleOpen accessIn the abstractHIV-1-Specific CTL Recognizing a Scarce Epitope Are Not Suppressed by HIV-1 Protease InhibitorsOtto O. YangHIV-1-protease inhibitors have received growing attention as agents that can affect proteases in human proteasomes, with potentially deleterious effects for HIV-1-specific cellular immunity. Studying the antiviral activity of HIV-1-specific CTL that recognize an epitope that is presented at limiting concentrations on infected cells, we find that several HIV-1 protease inhibitors do not affect their function. These data indicate that these … …American Journal of Immunology, Vol. 3, Issue 1 · 30 Jun 2007 · 7,016 accessesView PDF Cite