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32 articles for “Cell cycle”
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Review ArticleOpen accessIn the abstractHost Receptor Immunomodulation in Response to Shigella Surface Antigens: An Insight for Vaccine DevelopmentAshim K. Bagchi, Rushita A. Bagchi, Dipak K. Hens et al.Shigellosis, caused by Shigella is the most common cause of bacillary dysentery. The disease is associated with high morbidity and mortality rate owing to its multiple drug resistance. Hence recovery from the disease would primarily depend on the development of an effective immune-modulator for strong mucosal immune response. The role of cellular immunity may be a critical factor in protection … …American Journal of Immunology, Vol. 11, Issue 2 · 21 Jun 2015 · 6,752 accessesView PDFCite
Research ArticleOpen accessIn the abstractNeuronal Functions of Protein Phosphatase 2AHung-Tat Leung, Ning WangReversible protein phosphorylation is a common and important form of protein posttranslational modification which determines the proteins’ activities, substrate specificity and inhibitions or degradations, depending on the specific amino acid residue, or combination of residues, being targeted. While protein phosphorylations by kinases have been well studied, the importance of protein dephosphorylation by phosphatases has emerged over the past two decades … …Neuroscience International, Vol. 4, Issue 2 · 1 Apr 2014 · 7,777 accessesView PDFCite
Research ArticleOpen accessIn the abstractStructural and Evolutionary Analysis of PARPs in D. discoideumA. Mehadvi Kawal, Hina A. Mir, Chethan Kumar Ramniklal et al.Problem statement: Dictyostelium discoideum, a unicellular eukaryote, exhibits multicellularity upon nutrient starvation, making it a better model for developmental studies and for the study of various signal transduction pathways. The most felicitous point of interest is that many of its genes show high degree of similarity to vertebrate genes. Poly (ADP-ribose) polymerase (PARP), a ubiquitous and abundant nuclear protein, has … …American Journal of Infectious Diseases, Vol. 7, Issue 3 · 3 Nov 2011 · 7,852 accessesView PDFCite
Research ArticleOpen accessIn the abstractFuel and Greenhouse Gas Emission Reduction Potentials by Appropriate Fuel Switching and Technology Improvement in the Canadian Electricity Generation SectorFarshid Zabihian, Alan S. FungProblem statement: In recent years, Greenhouse Gas (GHG) emissions and their potential effects on global climate change have been a worldwide concern. According to International Energy Agency (IEA), power generation contributes more than half of the global GHG emissions. Approach: Purpose of this study is to examine GHG emission reduction potentials in the Canadian electricity generation sector through fuel switching … …American Journal of Engineering and Applied Sciences, Vol. 3, Issue 1 · 31 Mar 2010 · 8,031 accessesView PDFCite
Research ArticleOpen accessIn the abstractInvestigations in the molecular events of Transitional Cell Carcinoma of the BladderH.S. Kadhim, A.S. Abdulamir, R.R. Hafidh et al.Problem Statement: Transitional Cell Carcinoma (TCC) of the bladder is a significant health problem worldwide. The molecular mechanisms of tumor development and progression are complicated but likely involve the interaction of tumor suppressor genes, oncogenes, cell cycle regulatory proteins and other factors. Hence this study tries to explore the role of p53, bcl-2, c-myc and Ki-67 in TCC of the … …American Journal of Biochemistry and Biotechnology, Vol. 4, Issue 4 · 31 Dec 2008 · 7,528 accessesView PDFCite
Research ArticleOpen accessIn the abstractModelling and Analysis of Voltage Mode Controlled Luo ConverterDivya Navamani Jayachandran, Vijayakumar Krishnaswamy, Lavanya Anbazhagan, Karthikeyan DhandapaniThis paper presents the analysis of open loop power stage dynamics relevant to voltage mode control for elementary Luo DC-DC converter for certain specific applications like Hybrid Electric Vehicles, fuel cell vehicles. A comparative analysis is carried out on positive output super lift series of converters to evaluate voltage gain, output voltage ripple, stresses on the switches and efficiency. The … …American Journal of Applied Sciences, Vol. 12, Issue 10 · 7 Nov 2015 · 7,098 accessesView PDFCite
Research ArticleOpen accessIn the abstractCross Validation Evaluation for Breast Cancer Prediction Using Multilayer Perceptron Neural NetworksShirin A. Mojarad, Satnam S. Dlay, Wai L. Woo, Gajanan V. SherbetProblem statement: The presence of metastasis in the regional lymph nodes is the most important factor in predicting prognosis in breast cancer. Many biomarkers have been identified that appear to relate to the aggressive behaviour of cancer. However, the nonlinear relation of these markers to nodal status and also the existence of complex interaction between markers have prohibited an accurate … …American Journal of Engineering and Applied Sciences, Vol. 4, Issue 4 · 20 Feb 2012 · 7,699 accessesView PDFCite
Research ArticleOpen accessIn the abstractAAV-Based Targeting Gene TherapyWenfang Shi, Mingxia Yu, Qijun QianSince the first parvovirus serotype AAV2 was isolated from human and used as a vector for gene therapy application, there have been significant progresses in AAV vector development. AAV vectors have been extensively investigated in gene therapy for a broad application. AAV vectors have been considered as the first choice of vector due to efficient infectivity, stable expression and nonpathogenicity. … …American Journal of Immunology, Vol. 4, Issue 4 · 31 Dec 2008 · 6,960 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Murine Charged Multivesicular Body Protein 2A, CHMP2A Interacts with the 5' and 3' Terminal Regions of Dengue Virus Complementary Minus-strand RNASuchita Chaudhry, Sathyamangalam Swaminathan, Navin KhannaDengue (DEN) viruses, of which there are four distinct serotypes (DEN-1, -2, -3 and –4), belong to the Flaviviridae family. Their ‘plus’ sense RNA genomes contain Non-Translated Regions (NTRs) at their 5’ and 3’ ends. Replication of viral genomic RNA, which takes place in close association with host cell membranes, involves the initial synthesis of the complementary minus sense RNA … …American Journal of Infectious Diseases, Vol. 2, Issue 1 · 31 Mar 2006 · 7,314 accessesView PDFCite
Research ArticleOpen accessIn the abstractDesign and Analysis of Adders using Nanotechnology Based Quantum dot Cellular AutomataS. Karthigai Lakshmi, G. AthishaProblem statement: The area and complexity are the major issues in circuit design. Here, we propose different types of adder designs based on Quantum dot Cellular Automata (QCA) that reduces number of QCA cells and area compare to previous designs. The quantum dot cellular automata is a novel computing paradigm in nanotechnology that can implement digital circuits with faster speed, … …Journal of Computer Science, Vol. 7, Issue 7 · 30 Jun 2011 · 7,311 accessesView PDFCite