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49 articles for “Antigens”
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Research ArticleOpen accessIn the abstractTowards Identifying Immunogenic Targets in Visceral Leishmaniasis: Role of 17kDa and 63kDa PhosphoproteinsShubhankar K Singh, Sanjiva Bimal, Diwakar S. Dinesh et al.We observed predominant phosphorylation at Protein Kinase C (PKC-α) residue in seven immunoreactive proteins of virulent Leishmania donovani parasites. These phosphoproteins were tested for their ability to stimulate T-cells for secretion of Macrophage Migration Inhibition Factor (MIF) in comparision to crude soluble antigen in Visceral Leishmaniasis (VL) patients. Two of these phosphorylated L. donovani antigens led Leishmania to present these … …American Journal of Immunology, Vol. 1, Issue 3 · 30 Sep 2005 · 6,756 accessesView PDFCite
Research ArticleOpen accessIn the abstractComparative Evaluation of Aqueous and Freeze Dried Antigen for Sero-diagnosis of VL and PKDL Cases by DATSanjiva Bimal, Shubhankar K. Singh, P. K. Sinha et al.The efficacy of aqueous and freeze dried (FD) antigen was evaluated by direct agglutination test (DAT) for sero-diagnosis of visceral leishmaniasis. A total of 16 samples collected from 5 confirmed Kala-azar (KA) cases, 6 cases 2 each of filariasis, malaria, leprosy and 5 non-endemic healthy subjects were used in determination of cut off titre of both the antigens in DAT. … …American Journal of Immunology, Vol. 1, Issue 2 · 30 Jun 2005 · 6,834 accessesView PDFCite
EditorialOpen accessIn the abstractFocalize the Structure of Myd88 in TLR Signaling Pathway to Modulate Innate Immune Response: New Target for Old DiseasesShuai Xing, Ping ZhouAll diseases have their Achilles’ Heel to target and this is especially true for immunorelated diseases which must be treated by targeting the immune system somewhere and somehow correctly. In the most recent decade, immunologists recognized that the Toll-Like Receptor (TLR) signaling pathway in innate immune system plays a double-edged role in the pathogenesis of many notorious diseases. Although the … …American Journal of Immunology, Vol. 13, Issue 3 · 6 Sep 2017 · 7,862 accessesView PDFCite
Research ArticleOpen accessIn the abstractSevere and Fatal Influenza Cases in Russia in 2014-2015Svetlana V. Svyatchenko, Alexander G. Durymanov, Ivan M. Susloparov et al.This paper aims to characterize herd immunity of the population inhabiting Asian part of Russia before influenza epidemic and to describe influenza viruses isolated from severe cases including cases with fatal outcomes in the 2014-2015 epidemic season. HI test enabled us to study 3888 serum samples from healthy individuals including 1939 samples collected from poultry farm workers. We showed that … …OnLine Journal of Biological Sciences, Vol. 16, Issue 4 · 24 Dec 2016 · 7,064 accessesView PDFCite
Research ArticleOpen accessIn the abstractAntibody Responses to HIV-1 gp120 Hypervariable Regions in Six Long-Term Non-ProgressorsRebecca Rivera, Kyung Hee Kang, Murray B. Gardner et al.Our long-term goal is to discover the combination of host parameters that help some HIV-infected individuals to resist progression to AIDS. In this study, we examined antibody responses using multiple samples obtained from a cohort of Long-Term Non-Progressors (LTNPs). Our hypothesis is that antibody responses to variable regions of the HIV-1 envelope glycoprotein are involved in reducing the viral load … …American Journal of Infectious Diseases, Vol. 12, Issue 2 · 1 Jul 2016 · 7,649 accessesView PDFCite
Research ArticleOpen accessIn the abstractEconomic Evaluation of Streptococcus Pneumoniae Culture MediaVictor Morais, Norma SuárezStreptococcus pneumoniae, a major bacterial pathogen worldwide, requires a complex medium for culture, which complicates harvesting of antigens for vaccine production. Here we present an economic evaluation of factors affecting the production cost of a chemically defined medium for the scale up of fermentation of S. pneumoniae, compared with the most traditional fermentation media. A basic laboratory-scale experiment of 1 … …American Journal of Biochemistry and Biotechnology, Vol. 12, Issue 2 · 27 May 2016 · 8,374 accessesView PDFCite
Literature ReviewOpen accessIn the abstractThe Practical Consideration of Poliovirus as an Oncolytic VirotherapyElizabeth Denniston, Hannah Crewdson, Nicole Rucinsky et al.The inauguration of novel treatment strategies into the clinical setting faces a number of hurdles. In addition to treatment efficacy and safety, acceptance by doctors and patients is paramount to the success of novel therapies. Although viruses are the cause of numerous infectious diseases, these acellular entities have been harnessed over the years to benefit mankind. Recently, a recombinant Poliovirus-Rhinovirus … …Current Research in Virology, Vol. 5, Issue 1 · 3 Mar 2016 · 27,150 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Association of HLA Class II Alleles with the Response to Alfa-Interferon/Ribavirin Therapy in Chronic Hepatitis C PatientsAwny Aly Abol-Ez Gawish, Nahla Abd El-Hamid Mohammed, Rasha Adel Sayed Ahmed Hussein, Elsaid Galal El-BadrawyHuman Leucocyte Antigens (HLA) class II appears to play an important role in the individual’s immune response to viral infection. The present study was aimed at assessment of the relationship between HLA DRB1 alleles and the response to HCV combined therapy in Chronic Hepatitis C patients (CHC). We enrolled a total of 44 chronically infected HCV patients without Hepatitis B … …American Journal of Immunology, Vol. 11, Issue 3 · 12 Nov 2015 · 6,700 accessesView PDFCite
Review ArticleOpen accessIn the abstractVaccine against Jembrana Disease Virus Infection: A Summary FindingsAsmarani Kusumawati, Tenri Ashari Wanahari, Pudji Astuti et al.Jembrana disease constitutes the main concern in cattle industry especially in Indonesia and Australia as it has caused important economic losses due to mortality of cattle. The pathology of the disease is unusual for a lentivirus infection as it is associated with a severe, often lethal disease syndrome and a short incubation period in cattle. For lack of efficient medical … …American Journal of Immunology, Vol. 11, Issue 3 · 2 Sep 2015 · 7,851 accessesView PDFCite
EditorialOpen accessIn the abstractNeutrophil Extracellular Traps as Therapeutic Targets for Inflammatory DiseaseRory R. KoenenNeutrophilic granulocytes, or neutrophils are the most abundant circulating white blood cell and constitute a first line of defense against pathogens. They are characterized by a large polymorphic lobular nucleus and the presence of many secretory granules in their cytoplasm. Neutrophils are essential for a functional host defense, as is evidenced by the occurrence of severe infections in individuals with … …American Journal of Pharmacology and Toxicology, Vol. 9, Issue 4 · 25 Feb 2015 · 8,737 accessesView PDFCite