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48 results for “Alzheimer disease”
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Research ArticleOpen accessEvery word in the titleAlzheimer’s Disease Prognosis is Captured by a Down-Upsized Incidence Poisson DistributionRamalingam ShanmugamAlzeimer disease is a daunting nightmare to both the medical and families of the patients. Tireless efforts are made by the medical researchers to treat Alzheimer’s patients. The Alzhiemer patients’ data provides clues about its prognosis and they can be identifies when the data are analyzed and understood correctly. The data analysis is a first step in the path to … …Current Research in Medicine, Vol. 4, Issue 2 · 4 Sep 2013 · 6,926 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleA Review of Biochemical Markers for Early Diagnosis of Alzheimer’s DiseaseMeha Fatima Aftab, Rizwana S. WaraichAlzheimer’s disease, the most prevalent type of dementia, affects the life of elderly, to such extent that it impairs the ability to perform routine functions as well. The impairment of normal functions not only affects the patients but the family members as well. It is difficult to make a definitive diagnosis; hence some clinical and psychological tools are used to … …Neuroscience International, Vol. 3, Issue 2 · 4 Sep 2012 · 13,511 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleCognitive-Enhancing and Antioxidant Activities of Quercetin Liposomes in Animal Model of Alzheimer's DiseaseTerdthai Tong-un, Panakaporn Wannanon, Jintanaporn Wattanathorn, Wathita PhachonpaiProblem statement: Recent findings demonstrated the crucial role of oxidative stress on the pathophysiology of Alzheimer’s Disease (AD). Antioxidant intake is beneficial to delay or inhibit the progression of this disease. Quercetin, a bioflavonoid in fruits and vegetables, has a powerful antioxidant activity both in vitro and in vivo. Claims that quercetin has many biological activities. However, quercetin is rapidly … …OnLine Journal of Biological Sciences, Vol. 10, Issue 2 · 31 Oct 2010 · 7,880 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleBiomedicine and Informatics Model of Alzheimer's DiseaseKang Cheng, Chang-Hua ZouIn a perspective of biomedicine and informatics, the mechanism of Alzheimer's, senile amnesia, or other aging-associated and cognitive impairment related diseases involve four important informative processing procedures: propagation, consolidation, retrieval and cognition, In this study, we systematically model the four procedures based on published experimental data. When modeling the propagation, we develop an equivalent circuit of biological membrane to describe … …American Journal of Biochemistry and Biotechnology, Vol. 3, Issue 3 · 28 May 2007 · 6,824 accessesView PDFCite
Research ArticleOpen accessIn the keywordsWhale Optimized Deep Generative Adversarial Network Based Alzheimer's Stages Detection Using 3D MRI Brain NeuroimagingR. Sampath, M. BaskarAlzheimer's Disease (AD), a common, chronic neurodegenerative condition, is characterized by the loss of neurons and synapses in the cerebral cortex and specific subcortical regions. According to claims from a recent study, AD has a 20% misdiagnosis rate. Therefore, it is essential to create a useful tool to recognize the stages of AD with a lower prediction error rate to … …Journal of Computer Science, Vol. 19, Issue 8 · 4 Aug 2023 · 5,544 accessesView PDFCite
Research ArticleOpen accessIn the keywordsNasal Administration of Quercetin Liposomes Modulate Cognitive Impairment and Inhibit Acetylcholinesterase Activity in HippocampusTerdthai Tong-Un, Supaporn Muchimapura, Wathita Phachonpai, Jintanaporn WattanathornProblem statement: Oxidative stress is a major factor implicated in the degeneration of cholinergic neurons in Alzheimer’s Disease (AD). Several reports have indicated that antioxidant intake is beneficial to delay or inhibit the progression of this disease. Presently, Acetylcholinesterase (AChE) inhibitors are the mainstay of therapy for AD. Quercetin, one of the flavonoids in fruits and vegetables, has a powerful … …Neuroscience International, Vol. 1, Issue 1 · 30 Jun 2010 · 7,170 accessesView PDFCite
Research ArticleOpen accessIn the keywordsPrognosis of Dementia Using Early Fusion Approach with Digital Clock Drawing and Trail-Making TestsShridevi Karande, Vrushali KulkarniDementia poses a substantial global public health challenge. Emerging evidence suggests that COVID-19's neurological impact may aggravate dementia incidences. Timely recognition and management can significantly decelerate dementia progression and enhance affected individuals' quality of life. In the realm of cognitive assessment, the Clock Drawing Test (CDT) and Trail-Making Test (TMT) stand as prominent tools. Existing research predominantly focuses on the … …Journal of Computer Science, Vol. 20, Issue 8 · 10 Jun 2024 · 4,720 accessesView PDFCite
Research ArticleOpen accessIn the keywordsQSAR Modeling of Thirty Active Compounds for the Inhibition of the Acetylcholinesterase EnzymeNour El Houda Hammoudi, Yacine Benguerba, Widad SobhiThis work aims at developing a reliable and predictive QSAR model which allows, on one hand, an exploration of the main molecular descriptors responsible for the inhibitory activity towards the Acetylcholinesterase enzyme and, on the other hand, predict the inhibitory activity of new compounds before testing them experimentally. This study involves a series of DL0410 and its 29 DL0410 derivatives. … …Current Research in Bioinformatics, Vol. 8, Issue 1 · 2 Mar 2020 · 11,426 accessesView PDFCite
Research ArticleOpen accessIn the keywordsAdvanced Oxidation Protein Products in Aged with DementiaMelike Erol Demirbilek, Nedret Kilic, H. Ferhan Komurcu, K. Okhan AkinThe role of increased oxidative stress in the development of oxidative protein damage in aging have been reported. There is an important role of oxidative stress on development of dementia. Advanced oxidation protein products (AOPPs) are novel markers of oxidative stress. The aim of this study was to compare AOPP levels in healthy aged person and aged person with dementia. … …American Journal of Immunology, Vol. 3, Issue 2 · 31 Dec 2007 · 7,256 accessesView PDFCite
Research ArticleOpen accessIn the abstractFusing CNN Models for Improved Parkinson’s Disease Detection from Handwritten FeaturesSabrina Benredjem, Tahar MekhazniaNeurodegenerative Diseases (NGD) are a group of progressive neurological disorders, including cognitive decline as Alzheimer’s Disease (AD) and Parkinson’s Disease (PD) that result in the progressive loss of neuronal structure or function. This can lead to a variety of symptoms, in this study we are interested in PD one of the neurological diseases that causes the loss of dopamine-producing neurons … …Journal of Computer Science, Vol. 21, Issue 2 · 22 Jan 2025 · 6,306 accessesView PDFCite