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33 articles for “Acute Toxicity”
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Research ArticleOpen accessIn the abstractIn-Vivo Evaluation of Hexavalent Chromium Induced DNA Damage by Alkaline Comet Assay and Oxidative Stress in Catla catlaKantha Deivi Arunachalam, Sathesh Kumar Annamalai, Jaya Krishna KuruvaIn the present study, the acute toxicity of Chromium in fingerlings of Catla catla, an Indian major carp, was evaluated with renewal bioassay method. In vivo studies were designed to assess the extent of Micronucleus Assay, Comet Assay under the exposure of common heavy-metal compounds, namely, Chromium Nitrate, using Catla catla (2n = 20), as a test model. The laboratory … …American Journal of Environmental Sciences, Vol. 9, Issue 6 · 15 Jan 2014 · 7,196 accessesView PDFCite
Research ArticleOpen accessIn the abstractHYPOGLYCEMIC, HEPATO-RENAL AND ANTIOXIDANT POTENTIAL EFFECTS OF CHAMOMILE RECUTITA FLOWERS ETHANOLIC EXTRACT IN STREPTOZOTOCIN-DIABETIC RATSHassan Al-Musa, Fahaid AL-HashemThis study was undertaken to evaluate the hypoglycemic and hepatorenal protective effect of ethanolic extract of Chamomile recutita flowers in streptozotocin-Diabetic Rats. Before the beginning of the experiments, acute and subacute studies were carried out in control animals first to investigate the LD50 of this extract. In the experimental design, adult male albino rats were divided into five groups: (1) … …American Journal of Pharmacology and Toxicology, Vol. 9, Issue 1 · 9 Dec 2013 · 8,151 accessesView PDFCite
Research ArticleOpen accessIn the abstractCell-Based Therapies in the Prevention of Solid Organ Transplant RejectionAdrian E. Morelli, Sherrie J. DivitoProblem statement: Organ transplantation is a life-saving and increasingly common procedure, as it often serves as the only treatment available for end-stage organ disease. Although the constant development of new and more effective immunosuppressive drugs has revolutionized the prevention and treatment of acute graft rejection, these drugs have significant toxicity, greatly increase patient susceptibility to neoplasms and infection and exert … …American Journal of Immunology, Vol. 8, Issue 2 · 26 Jul 2012 · 7,416 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe 100-Days Oral Toxicity of Tomato Pomace in Healthy MiceWathita Phachonpai, Supaporn Muchimapura, Jintanaporn Wattanathorn et al.Problem statement: Growing attention is being paid to functional food. The beneficial effect of functional food appears to relate to its bioactive ingredient such as substances containing antioxidant. Therefore, the information about the toxicity of the substances is very much essential to recommend the safety for the substances implication in both clinical and application trials. Herein, we have investigated for … …American Journal of Pharmacology and Toxicology, Vol. 7, Issue 1 · 23 May 2012 · 7,601 accessesView PDFCite
Research ArticleOpen accessIn the abstractUsing Bioequivalence Approach to Assess Toxicity Effect of Herbal Products, TyrelTM and RumbionTMChunhao Tu, Woon Yuen KohProblem statement: Herbal products have been widely used in veterinary healthcare. Recently, an experiment was conducted in the Natural Animal Facility Pvt. Ltd., Bangalore, India on ten Albino Wistar female mice to assess the acute oral toxicity of two herbal products, TyrelTM and RumbionTM. However, the researchers did not evaluate the toxicity effect of the two products in terms of … …American Journal of Pharmacology and Toxicology, Vol. 5, Issue 2 · 30 Jun 2010 · 7,823 accessesView PDFCite
Research ArticleOpen accessIn the abstractAnti-Ulcer (Ulcer-Preventive) Activity of Ficus arnottiana Miq. (Moraceae) Leaf Methanolic ExtractMarslin Gregory, K. P. Vithalrao, G. Franklin, V. KalaichelavanProblem statement: In spite of being one of the well-known medicinal plants used in Indian traditional medicine to treat several ailments, studies pertaining to the pharmacological properties of Ficus arnottiana are very scarce. We studied the anti-ulcer activity and acute toxicity of Ficus arnottiana leaf methanolic extract for the first time. Approach: Freshly collected F. arnottiana leaves were dried, powdered … …American Journal of Pharmacology and Toxicology, Vol. 4, Issue 3 · 30 Sep 2009 · 9,329 accessesView PDFCite
Research ArticleOpen accessIn the abstractAnti-Inflammatory Activity of Vitex leucoxylon L. Bark Extracts Against Freund's Complete Adjuvant Induced Arthritis in Sprague Dawley RatAlluri V. Krishnaraju, Chundi B.M. Rao, Dodda Sundararaju et al.Problem statement: Anti-inflammatory agents, particularly steroids and cyclooxygenase inhibitors are often associated with adverse side effects including, GI irritation, ulcers, hypertension and cardiac abnormalities. A safe and effective intervention is essential for the treatment of inflammatory disorders. Approach: Abstract Vitex leucoxylon L., a medicinal plant of the verbenaceae family, used in traditional medicine for relieving headache and catarrh. VL-89/185A, was … …American Journal of Infectious Diseases, Vol. 5, Issue 2 · 30 Jun 2009 · 8,044 accessesView PDFCite
Research ArticleOpen accessIn the abstractA Mathematical Modeling Approach to Characterize Hormesis, Caloric Restriction and Toxicity in Mortality Data from Toxicity StudiesPatricia J. NeafseyThe mortality of a population reflects the combined effects of natural aging with environmental insults (e.g. toxicant exposure, caloric restriction, over feeding, infections, etc.). No single endpoint, such as carcinogenesis, completely describes toxicant-induced effects in laboratory animals. Mathematical models of mortality and time-dependent exposure to toxicants can yield indices of net injury from all causes. With careful manipulation of diet … …American Journal of Pharmacology and Toxicology, Vol. 3, Issue 1 · 31 Mar 2008 · 7,160 accessesView PDFCite
Research ArticleOpen accessIn the abstractCurcuma longa, Glycyrrhiza glabra and Moringa oleifera Ameliorate Diclofenac-induced Hepatoxicity in RatsAlaaeldin A. HamzaAlthough treatment with therapeutic agents may be one of the main causes of liver toxicity, there have been only limited attempts at thorough research efforts to seek solution. Diclofenac (DIC) is a widely used anti-inflammatory drug that causes liver toxicity. This DIC-induced hepatotoxicity was found to be associated with oxidative damage. In this report, extracts of herbal plants that are … …American Journal of Pharmacology and Toxicology, Vol. 2, Issue 2 · 30 Jun 2007 · 9,614 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Value of Serologic Tests for Diagnosis and Follow up of Patients having BrucellosisNidia E. Lucero, Sandra M. Ayala, Gabriela I. Escobar, N R. JacobThough diagnosis of human brucellosis is accurate when the causal agent is isolated, this procedure is not always successful and the most of patients are diagnosed on the basis of rising titres of antibodies in serum. The classical tests used for detection of antibodies to S-Brucella sp., include Rose Bengal (RBT), buffered plate antigen (BPAT), serum agglutination (SAT), 2-mercapto-ethanol (2MET) … …American Journal of Infectious Diseases, Vol. 3, Issue 1 · 31 Mar 2007 · 7,446 accessesView PDFCite