Research ArticleOpen accessAll words, across the recordSelective Lymphocyte Activation and Inhibition of In Vitro Tumor Cell Growth by Novel MorphinansRicardo Gomez-Flores, Kimberly R. Vietti, William J. Dunn et al.Opioids can suppress immune functions and increase susceptibility to developing cancer and infectious diseases. Recently, novel opioid compounds have been synthesized that lack immunosuppressive effects. We evaluated the effects of morphinans with substituted pyrimidine (methyl, phenyl, hydroxy, and amino groups) and pyrazole groups on in vitro rat thymic lymphocyte and splenic macrophage functions, and tumor cell growth. We observed that … …American Journal of Immunology, Vol. 2, Issue 1 · 5 Mar 2005 · 7,078 accessesView PDFCite