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Research ArticleOpen accessIn the abstractEmploying New Mathematical Models and Equations to Evaluate Risk-Benefit Criteria of Clinical TherapeuticsDa Yong Lu, Ting Ren Lu, Jian DingCurrent preclinical and clinical evaluation of a drugs or therapy is at first to find out a maximum toxicity tolerance, which is overall fixed. The potential therapeutic dosage will be ranged just lower or within the periphery of these maximum tolerant data. A hidden acceptance among general researchers lies as the toxicity concentration of a drug is always the same … …OnLine Journal of Biological Sciences, Vol. 7, Issue 1 · 30 Jun 2007 · 6,829 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Effect of Vitamin C on the Metabolic Parameters of Experimental Diabetes MellitusMariam Al-Shamsi, Amr Amin, Ernest AdeghateThe role of vitamin C on diabetes mellitus is unknown. The purpose of this study was to examine the effect of oral administration of vitamin C on some of the metabolic parameters of diabetic rats. Diabetes was induced by intraperitoneal injection of STZ (60 mg kgˉ1 body weight at 12 weeks of age). Vitamin C (10, 50, 100 mg kgˉ1 … …American Journal of Pharmacology and Toxicology, Vol. 2, Issue 1 · 31 Mar 2007 · 8,072 accessesView PDFCite
Research ArticleOpen accessIn the abstractSuccessful Treatment of Both Mother and Infant in Pregnancy-Associated Group A Streptococcal Toxic Shock SyndromeTakayuki Tanaka, Kousaku Matsubara, Yumiko Umemoto et al.All perinatal cases of group A streptococcal toxic shock syndrome (STSS) previously documented in English literature have been fatal for the mother, the fetus or both. We present the first report of successful treatment of a mother-infant pair with perinatal STSS. A pregnant woman developed STSS at 34 weeks’ gestation 3 h after delivery, following a 25-h history of fever … …American Journal of Infectious Diseases, Vol. 3, Issue 1 · 31 Mar 2007 · 7,093 accessesView PDFCite
Research ArticleOpen accessIn the abstractApplications of Real-time Reverse Transcription Polymerase Chain Reaction in Clinical Virology Laboratories for the Diagnosis of Human DiseasesR. Manojkumar, V. MrudulaEarly diagnosis that prevents further expansion of the causative agent and thereby aids control and eradication of infectious agents is critical for countries trying to obtain a particular disease free status. In these diagnostics speed is paramount, including the assay’s applicability, sensitivity, specificity, cost effectiveness and patentability. Real-time Reverse Transcription PCR (rRT-PCR) has revolutionized the field of molecular biology and … …American Journal of Infectious Diseases, Vol. 2, Issue 4 · 31 Dec 2006 · 6,557 accessesView PDFCite
Research ArticleOpen accessIn the abstractLeptin and Adiponectin in the HIV Associated Metabolic Syndrome: Physiologic and Therapeutic ImplicationsSotirios Tsiodras, Christos MantzorosLeptin and adiponectin represent two newly discovered adipose tissue derived hormones with important roles in energy homeostasis and insulin resistance. Their interrelations with the manifestations of the HIV associated metabolic syndrome and specific somatomorphic changes i.e. fat redistribution is reviewed. A synopsis of published studies is presented and the potential role of leptin and adiponectin is discussed. We have described … …American Journal of Infectious Diseases, Vol. 2, Issue 3 · 30 Sep 2006 · 10,103 accessesView PDFCite
Research ArticleOpen accessIn the abstractRecreational Viagra Use and Sexual Risk among Drug Abusing MenDennis G. Fisher, Robert Malow, Rhonda Rosenberg et al.Until recently, the Viagra connection to HIV was anchored in older adults. However, CDC investigation showed stability in 50+ HIV diagnoses on the heels of upward trends in risk indicators among men who have sex with men (MSM) and substance abusing populations. Signs have increasingly pointed to recreational drug use among younger populations, to which Viagra is being added to … …American Journal of Infectious Diseases, Vol. 2, Issue 2 · 30 Jun 2006 · 10,610 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Changing Pathology of NeuroAIDS Associated with Drug Abuse in the Era of HAARTE Bell Jeanne, C. Anthony Iain, Simmonds PeterCompliance with highly active antiretroviral therapy (HAART) arrests HIV induced immune collapse and reduces the prevalence of severe central nervous system (CNS) complications, including HIV associated dementia and encephalitis. However minor cognitive disorders remain common and recent autopsy studies have demonstrated the presence of subtle neuropathological abnormalities in HAART treated individuals, including persistent neuroinflammation and enhanced deposition in the brain … …American Journal of Infectious Diseases, Vol. 2, Issue 2 · 30 Jun 2006 · 6,874 accessesView PDFCite
Research ArticleOpen accessIn the abstractTopical Cyclosporine A in Corneal Graft RejectionMahmood Nejabat, Jafar Khoshghadam, Masoomeh Eghtedari, Hamid HosseiniCorneal graft rejection is now the most common cause of graft failure after penetrating keratoplasty. This study was designed to determine whether, addition of 2% topical cyclosporine (CSA) to local and systemic steroids in treatment of endothelial corneal allograft rejection, would improve the outcome. A prospective randomized treatment trial was carried out on 40 consecutive corneal graft recipients, presenting with … …American Journal of Immunology, Vol. 2, Issue 2 · 30 Jun 2006 · 7,320 accessesView PDFCite
Research ArticleOpen accessIn the abstractIntroduction of Three Complementary Technologies into Clinical Medicine: Development of New Diagnostic and Prognostic ParametersGernot P. Tilz, Marco Wiltgen, Ulrike Demel et al.Molecular medicine leads us to understand some diseases at the molecular level. Examples are the analysis of immune complexes and receptor - anti receptor compounds used in clinical medicine. Structural changes of some serum proteins occur in inflammation, neoplasie and autoimmunity. The detection and analysis of such structural modifications may offer a new field for the diagnosis, prognosis and therapy … …American Journal of Immunology, Vol. 2, Issue 1 · 31 Mar 2006 · 6,961 accessesView PDFCite
Research ArticleOpen accessIn the abstractSurvival in the Current Healthcare Environment How Close Are We to Socialized Medicine?Eldo E. FrezzaIn the 1980's, some hospitals established internal agencies to regulate cash flow and capital expense. State agencies promoted the evolution of healthcare facilities into more business-like organizations. Attention to the following matters will reduce hospital costs: 1) prevent or reduce nosocomial infections; 2) treat diseases at a stage amenable to outpatient therapy; 3) obtain complete information about the policies of … …Journal of Social Sciences, Vol. 1, Issue 4 · 31 Dec 2005 · 6,693 accessesView PDFCite