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Research ArticleOpen accessIn the abstractA New Text Mining Approach for Finding Protein-to-Disease AssociationsHisham Al-Mubaid, Rajit K. SinghDiscovering significant relationships between biological entities from text documents is an important task for biologists in order to develop biological models for research and discovery, especially with the existing gigantic amounts of biomedical documents and the rate at which they are increasing everyday. We propose a new text mining method to extract associations between biological entities from text documents; and … …American Journal of Biochemistry and Biotechnology, Vol. 1, Issue 3 · 30 Sep 2005 · 7,015 accessesView PDF Cite

Research ArticleOpen accessIn the abstractApplication of RNA-DNA Duplex Base Triplets to Antisense DrugsJie Yang, Yao Leng, Ju BaoSixty-four sets of three-dimensional models of RNA-DNA duplex base triplets were constructed based on codons by homology modeling method using software InsightII on Indigo workstation, which should be helpful for the study of RNA-DNA annealing, the basis of nucleic acids interactions and some peculiar motifs for design antisense oligonucleotides. Our research result reveal that the energies (such as E, Ec, … …American Journal of Biochemistry and Biotechnology, Vol. 1, Issue 2 · 30 Jun 2005 · 6,534 accessesView PDF Cite

Research ArticleOpen accessIn the abstractA New Method to Estimate Intrinsic Parameters in the Ping-pong Bisustrate Kinetic: Application to the Oxipolymerization of PhenolJosé L. Gómez, Antonio Bódalo, Elisa Gómez et al.A new method for determining the intrinsic parameters of reaction in processes involving a high initial rate has been developed. The usefulness of this alternative, which consists of determining several sets of apparent parameters at different times and then extrapolating these to time zero, is demonstrated proved by the linear dependence obtained between the apparent parameters and the reaction time. … …American Journal of Biochemistry and Biotechnology, Vol. 1, Issue 2 · 30 Jun 2005 · 6,534 accessesView PDF Cite

Research ArticleOpen accessIn the abstractAssociation of Landscape Metrics to Surface Water Biology in the Savannah River BasinMaliha S. Nash, Deborah J. Chaloud, Susan E. FransonSurface water quality for the Savannah River basin was assessed using water biology and landscape metrics. Two multivariate analyses, partial least square and canonical correlation, were used to describe how the structural variation in landscape metrics may affect surface water biology and to define the key landscape variable(s) that contribute the most to variation in surface water quality. The results … …Journal of Mathematics and Statistics, Vol. 1, Issue 1 · 31 Mar 2005 · 6,298 accessesView PDF Cite

Research ArticleOpen accessIn the abstractEvaluation of Transcript Labeling Techniques and Development of a Membrane-based Parallel Gene Expression AssayMark A. Fisher, Bonnie B. Plikaytis, Thomas M. ShinnickAn inexpensive alternative to micro arrays was developed to examine the expression of small sets of genes in parallel and used to compare direct and indirect transcript labeling methods. Psoralen-biotin direct labeling was ~10-fold less sensitive than reverse transcriptase-biotin-dUTP labeling, but the enzymatic method generated higher levels of background noise in miniarray hybridizations. The reproducibility of hybridization intensities was the … …American Journal of Biochemistry and Biotechnology, Vol. 1, Issue 1 · 31 Mar 2005 · 6,875 accessesView PDF Cite

Research ArticleOpen accessIn the abstractEnergy and Carbon Flux Coupling: Multi-ecosystem Comparisons Using Artificial Neural NetworkAssefa M. Melesse, Rodney S. HanleyA multi-ecosystems carbon flux simulation from energy fluxes is presented. A new statistical learning technique based on Artificial Neural Network (ANN) back propagation algorithm and multi-layer perceptron architecture was used in the CO2 simulation. Four input layers (net radiation, soil heat flux, sensible and latent heat flux) were used for training (calibration) and testing (verification) of model outputs. The 15-days … …American Journal of Applied Sciences, Vol. 2, Issue 2 · 28 Feb 2005 · 7,349 accessesView PDF Cite