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281 articles for “Inhibitor”
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Research ArticleOpen accessIn the abstractLow-Birth Weight and Pre-Term Delivery in Relation to Lopinavir/Ritonavir Use in PregnancyJorge Senise, Reisson Cruz, Ricardo Palacios et al.The toxic potential of nevirapine in pregnant women with CD4 count over 250 cells mm-3 and the unsatisfactory efficacy of nelfinavir in patients with baseline Viral Load (VL) over 100,000 copies mL-1 has prompted the use of Lopinavir/ritonavir (LPV/r) in selected situations. This study aims to assess safety of LPV/r in pregnancy. Medical records from pregnant women receiving LPV/r were … …American Journal of Infectious Diseases, Vol. 4, Issue 4 · 31 Dec 2008 · 6,954 accessesView PDFCite
Research ArticleOpen accessIn the abstractAntibacterial and Antioxidant Activities of Typhonium Flagelliforme (Lodd.) Blume TuberSyam Mohan, Ahmad Bustamam Abdul, Siddig Ibrahim Abdel Wahab et al.Problem Statement: Multiple drug resistance in human pathogenic micro organisms has developed due to indiscriminate use of modern antimicrobial drugs generally used in the management of infectious diseases. This increases the importance of exploiting the natural sources instead modern drugs. Approach: The antibacterial and antioxidant activity of different extracts from of Typhonium flagelliforme (L.) Blume tuber (family: Araceae) commonly called … …American Journal of Biochemistry and Biotechnology, Vol. 4, Issue 4 · 31 Dec 2008 · 10,420 accessesView PDFCite
Research ArticleOpen accessIn the abstractA Review on Physicochemical and Thermorheological Properties of Sago StarchA. Mohamed, B. Jamilah, K.A. Abbas et al.This study was a part of a research project aiming to investigate the texture characteristics of protein - starch interaction in fish based product keropok lekor. Accordingly, the current review study focused on some physicochemical (molecular weight, viscosity, chemical composition and swelling power) and thermorheological (gelatinization, retrogradation and viscoelsticity) characteristics of sago starch alone and in mixtures with other ingredients … …American Journal of Agricultural and Biological Sciences, Vol. 3, Issue 4 · 31 Dec 2008 · 9,639 accessesView PDFCite
Research ArticleOpen accessIn the abstractStudy of the Allelopathic Potential of Extracts of Azadirachta Indica (Neem)Zoheir Y. Ashrafi, Aptin Rahnavard, Sedigheh Sadeghi et al.The allelopathic potential of extracts of Azadirachta indica L., which is one of the most dominant weeds in tropical regions of South-west Asia, was investigated under laboratory conditions. The n-hexane-soluble, acetone-soluble and water-soluble fractions obtained from the acetone extract of A. indica shoots inhibited the germination and the growth of roots and shoots of six test plant species. The inhibitory … …OnLine Journal of Biological Sciences, Vol. 8, Issue 3 · 30 Sep 2008 · 7,841 accessesView PDFCite
Research ArticleOpen accessIn the abstractZerumbone: A Natural Compound with Anti-Cholinesterase ActivityAhmad Bustamam, Siddig Ibrahim, Adel S. Al-Zubairi et al.Herbal dugs could be a new source for inhibitors of acetyl cholinesterase (anti-AChE), the key enzyme in the breakdown of acetylcholine and a new talented approach for the cure of elderly neurologically associated disorders such as Alzheimer’s disease (AD). Zerumbone (ZER) is sesquiterpene from the edible plant, Zingiber zerumbet which is known to possess tremendous biological activities. In this study, … …American Journal of Pharmacology and Toxicology, Vol. 3, Issue 3 · 30 Sep 2008 · 9,638 accessesView PDFCite
Research ArticleOpen accessIn the abstractHydrophobic, Polar and Hydrogen Bonding Based Drug-Receptor Interaction of TetrahydroimidazobenzodiazepinonesV.K. Sahu, A.K.R. Khan, R.K. Singh, P.P. SinghAnti-HIV drug discovery has been increasingly focusing on HIV-1-RT (reverse transcriptase) as a potential therapeutic target. Tetrahydroimidazobenzodiazepinone (TIBO) belongs to non-nucleoside group of reverse transcriptase inhibitors (NNRTIs). A computational chemistry study has been performed on a series of tetrahydroimidazo-benzodiazepinones as HIV-1-NNRT inhibitors. Problem statement: In order to search out new drug of desired activity from the lead compounds, there was … …American Journal of Immunology, Vol. 4, Issue 3 · 30 Sep 2008 · 8,837 accessesView PDFCite
Research ArticleOpen accessIn the abstractOxidative Stress in Autism: Elevated Cerebellar 3-nitrotyrosine LevelsElizabeth M. Sajdel-Sulkowska, Boguslaw Lipinski, Herb Windom et al.It has been suggested that oxidative stress and/or mercury compounds play an important role in the pathophysiology of autism. This study compared for the first time the cerebellar levels of the oxidative stress marker 3-nitrotyrosine (3-NT), mercury (Hg) and the antioxidant selenium (Se) levels between control and autistic subjects. Tissue homogenates were prepared in the presence of protease inhibitors from … …American Journal of Biochemistry and Biotechnology, Vol. 4, Issue 2 · 30 Jun 2008 · 17,119 accessesView PDFCite
Research ArticleOpen accessIn the abstractOn the Hormetic Behaviour of Drugs Binding to Different Redox States of Amine Oxidase EnzymesDeepak Narang, G. Reid McDonald, David J. Smith et al.Classical monoamine oxidases and copper-containing semicarbazide-sensitive amine oxidases are drug targets for a variety of established and novel pharmaceuticals used to treat conditions such as depression, Parkinsonism and inflammatory disorders. Development of enzyme inhibitors, both historically and currently, assumes an underlying adherence of these enzymes to Michaelis-Menten kinetic principles. In this mini-review, we discuss historical data from several laboratories and … …American Journal of Pharmacology and Toxicology, Vol. 3, Issue 1 · 31 Mar 2008 · 6,928 accessesView PDFCite
Research ArticleOpen accessIn the abstractVariations in Four Genotypes of Lentil under NaCl-Salinity StressM. Sidari, C. Santonoceto, U. Anastasi et al.Four lentil cultivars, Eston (E), Rossa of Castelluccio (RC), Pantelleria (P) and Ustica (U) differing in salt sensitivity, were examined for osmolyte contents and activities of α-amylase, β-amylase and α-glucosidase enzymes involved in seed germination, in absence as well as in presence of 50, 100, 150 and 200 mM NaCl. The inhibitory effects of NaCl differed, depending on the genotypes … …American Journal of Agricultural and Biological Sciences, Vol. 3, Issue 1 · 31 Mar 2008 · 8,702 accessesView PDFCite
Research ArticleOpen accessIn the abstractEvaluation of the Upland Weed Control Potentiality of Green Tea Waste-Rice Bran Compost and Its Effect on Spinach GrowthM.A.I. Khan, K. Ueno, S. Horimoto et al.This study evaluated the upland weed control potentiality, germination inhibition ability and growth suppression efficiency of the five combinations of green tea waste - rice bran compost (GRC). GRC was prepared by mixing green tea waste and rice bran at five ratios, and allowed to decompose for 5 mo. Application of GRC suppressed weed growth up to 93.4% in number … …American Journal of Agricultural and Biological Sciences, Vol. 2, Issue 3 · 30 Sep 2007 · 8,203 accessesView PDFCite