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270 results for “S-9 Fraction”
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Research ArticleOpen accessIn the abstractCryptolepine Provokes Changes in the Expression of Cell Cycle Proteins in Growing CellsCharles Ansah, Nigel J. GooderhamProblem statement: Cryptolepine, the antimalarial plant alkaloid is cytotoxic to mammalian cells, but there is rather little understanding of the possible mechanisms involved in the cell-kill action of cryptolepine. Approach: We examined mammalian cells exposed to cryptolepine (0.5-5.0 μM) for effects on the cell cycle and associated alterations in the levels of major regulatory proteins using immunoblotting and flow cytometry. … …American Journal of Pharmacology and Toxicology, Vol. 4, Issue 4 · 31 Dec 2009 · 7,396 accessesView PDFCite
Research ArticleOpen accessIn the abstractInvolvement of Microsomal Na+/K+ ATPase Activity in the Mechanism of Action of Dopaminergic D2 ReceptorsAbdulrahim Abu-JayyabProblem statement: Our previous research has shown that mitochondrial ATPase may have a role in the action of dopaminergic D2 receptors. It is therefore, thought of interest to investigate the effect of bromocriptine, sulpiride or their combination on the mitochondrial and microsomal ouabain sensitive and ouabain insensitive Na+/K+-ATPase in the liver of rats. Approach: In vivo treatment was carried out … …American Journal of Pharmacology and Toxicology, Vol. 4, Issue 4 · 31 Dec 2009 · 6,971 accessesView PDFCite
Research ArticleOpen accessIn the abstractA New Polyoxypregnane Glycoside from the Roots of Dregea volubilis (L.f) Benth. ex Hook. f and its Chondroprotective EffectSaksri Sanyacharernkul, Akanit Itghiarbha, Prachya Kongtawelert et al.Problem statement: Dregea genus (Asclepiadaceae) is well known for the rich of steroid pregnane contents and these plants are famous for the potential to be applied as alternative biological activities. Dregea volubilis is the only species of Dregea genus in Thailand. The chemical and biological investigations of this plant are interesting to bioassay-guided fractionation, particularly chondroprotective effect. Approach: The research … …American Journal of Biochemistry and Biotechnology, Vol. 5, Issue 4 · 31 Dec 2009 · 7,455 accessesView PDFCite
Research ArticleOpen accessIn the abstractAnticancer Activities of Styrylpyrone from the Leaves and Twigs of Goniothalamus maewongensis via Cell Cycle ArrestPradit Pradupsri, Chatchanok Loetchutinat, Narong Nuntasaen et al.Problem statement: Goniothalamus maewongensis is one of three new species which are found in Thailand recently. The genus goniothalamus is not only well known for the rich of styrylpyrones but also famous for the potential of biological activities, especially the cytotoxic activity against a number of human cancer cell lines. The phytochemical and biological investigations of this plant are interesting … …American Journal of Applied Sciences, Vol. 6, Issue 12 · 31 Dec 2009 · 8,192 accessesView PDFCite
Research ArticleOpen accessIn the abstractRocks with Asbestos: Risk Evaluation by Means of an Abrasion TestBellopede Rossana, Clerici Carlo, Marini Paola, Zanetti GiovannaNaturally occurring asbestos and asbestiform minerals can be found in metamorphic rocks and in the soil of the alluvial plains. Problem statement: The definition of the "free-asbestos rock" and the limit to consider a rock or a soil safe is still a controversial issue. American and European laws did not present any method to define the hazard of the green … …American Journal of Environmental Sciences, Vol. 5, Issue 4 · 31 Oct 2009 · 7,667 accessesView PDFCite
Research ArticleOpen accessIn the abstractDistribution of β-Glucosidase Activity within Aggregates of a Soil Amended with Organic FertilizersSaeid Hojati, Farshid NourbakhshProblem statement: Distribution pattern of enzyme activities in soil aggregate size classes as affected by organic amendments is not well understood. Approach: A study was conducted to evaluate the effects of repeated annual application of Cow Manure (CM), Sewage Sludge (SS) and Municipal Solid Waste Compost (MSW) on the distribution of β-Glucosidase (βG) activity within aggregates of a soil. Soil … …American Journal of Agricultural and Biological Sciences, Vol. 4, Issue 3 · 30 Sep 2009 · 8,183 accessesView PDFCite
Research ArticleOpen accessIn the abstractAntimicrobial Activity of Some Medicinal Plants from MalaysiaKoshy Philip, Sri Nurestri Abd Malek, Wirakarnain Sani et al.Problem statement: About 32 extracts from eight selected medicinal plants, namely Pereskia bleo, Pereskia grandifolia, Curcuma aeruginosa Roxb., Curcuma zedoria, Curcuma mangga, Curcuma inodora aff. Blatter, Zingiber officinale var. officinale (jahe gajah) and Zingiber officinale var. rubrum (jahe emprit) used by Malaysia traditional health care systems were screened for their antimicrobial activity against both Gram-positive bacteria and Gram-negative bacteria using … …American Journal of Applied Sciences, Vol. 6, Issue 8 · 31 Aug 2009 · 9,728 accessesView PDFCite
Research ArticleOpen accessIn the abstractAnti-Inflammatory Activity of Vitex leucoxylon L. Bark Extracts Against Freund's Complete Adjuvant Induced Arthritis in Sprague Dawley RatAlluri V. Krishnaraju, Chundi B.M. Rao, Dodda Sundararaju et al.Problem statement: Anti-inflammatory agents, particularly steroids and cyclooxygenase inhibitors are often associated with adverse side effects including, GI irritation, ulcers, hypertension and cardiac abnormalities. A safe and effective intervention is essential for the treatment of inflammatory disorders. Approach: Abstract Vitex leucoxylon L., a medicinal plant of the verbenaceae family, used in traditional medicine for relieving headache and catarrh. VL-89/185A, was … …American Journal of Infectious Diseases, Vol. 5, Issue 2 · 30 Jun 2009 · 8,044 accessesView PDFCite
Research ArticleOpen accessIn the abstractSimple and Rapid Method of Isolating Humic Acids from Tropical Peat Soils (Saprists)Shamsuddin Rosliza, Osumanu Haruna Ahmed, Kasim Susilawati et al.Problem Statement: The isolation (extraction, fractionation and purification) of humic acids (HA) from soils is laborious, time consuming and expensive. The extraction, fractionation and purification periods of these substances vary from 12 h-7 days. In order to facilitate production of HA at competitive cost, this study was conducted to investigate whether a simple and rapid procedure could be developed for … …American Journal of Applied Sciences, Vol. 6, Issue 5 · 31 May 2009 · 8,552 accessesView PDFCite
Research ArticleOpen accessIn the abstractSimple Method of Purifying Humic Acids Isolated from Tropical Hemists (Peat Soil)Susilawati Kasim, Osumanu Haruna Ahmed, Nik Muhamad Ab. Majid, Mohd Khanif YusopThe objectives of this study were: To investigate whether a purification period of HA isolated from Hemists peat soils could be reduced and to investigate whether distilled water could be used to purify HA isolated from Hemists peat soils. Standard procedures were used to extract and fractionate HA in a Hemists peat soil. The isolated HA was purified by suspending … …American Journal of Applied Sciences, Vol. 5, Issue 12 · 31 Dec 2008 · 7,151 accessesView PDFCite