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256 articles for “marker”
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Research ArticleOpen accessIn the abstractThe Antidiabetic Efficacy of Combined Extracts from Two Continental Plants: Azadirachta indica (A. Juss) (Neem) and Vernonia amygdalina (Del.) (African Bitter Leaf)Patrick Ekong Ebong, Item Justin Atangwho, Eyong Ubana Eyong, Godwin Eneji EgbungPolyherbal therapy is said to be a current pharmacological principle having the advantage of producing maximum therapeutic efficacy with minimum side effects. We assessed the antidiabetic efficacy and hence the impact on biochemical indices of toxicity by a combination of extracts from neem and bitterleaf. Thirty rats, 25 diabetic and 5 non-diabetic rats, were used for the study. The diabetic … …American Journal of Biochemistry and Biotechnology, Vol. 4, Issue 3 · 31 Aug 2008 · 14,400 accessesView PDFCite
Research ArticleOpen accessIn the abstractA Novel Rodent Model of Autism: Intraventricular Infusions of Propionic Acid Increase Locomotor Activity and Induce Neuroinflammation and Oxidative Stress in Discrete Regions of Adult Rat BrainDerrick F. MacFabe, Karina Rodríguez-Capote, Jennifer E. Hoffman et al.Innate neuroinflammatory changes, increased oxidative stress and disorders of glutathione metabolism may be involved in the pathophysiology of autism spectrum disorders (ASD). Propionic acid (PPA) is a dietary and gut bacterial short chain fatty acid which can produce brain and behavioral changes reminiscent of ASD following intraventricular infusion in rats. Adult Long-Evans rats were given intraventricular infusions of either PPA … …American Journal of Biochemistry and Biotechnology, Vol. 4, Issue 2 · 30 Jun 2008 · 12,613 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Autistic Phenotype Exhibits a Remarkably Localized Modification of Brain Protein by Products of Free Radical-Induced Lipid OxidationTeresa A. Evans, Sandra L. Siedlak, Liang Lu et al.Oxidative damage has been documented in the peripheral tissues of autism patients. In this study, we sought evidence of oxidative injury in autistic brain. Carboxyethyl pyrrole (CEP) and iso[4]levuglandin (iso[4]LG)E2-protein adducts, that are uniquely generated through peroxidation of docosahexaenoate and arachidonate-containing lipids respectively, and heme oxygenase-1 were detected immunocytochemically in cortical brain tissues and by ELISA in blood plasma. Significant … …American Journal of Biochemistry and Biotechnology, Vol. 4, Issue 2 · 30 Jun 2008 · 8,724 accessesView PDFCite
Research ArticleOpen accessIn the abstractGeographic Distribution and Genetic Analysis of Physiological Racesof Setosphaeria turcica in Northern ChinaJingao Dong, Yongshan Fan, Xiumei Gui et al.Five hundreds and forty-six isolates of Setosphaeria turcica, the causal agent of Northern Corn Leaf Blight, were collected in 61 corn-growing locations throughout six provinces of Northern China during 2000-2002, to determine their pathogenicity on two sets of host differentials: OH43/Huangzao4, OH43Ht1Huangzao4Ht1, OH43Ht2/Huangzao4Ht2, OH43Ht3/Huangzao4Ht3 and OH43HtN/Huangzao4HtN. The isolates were grouped into 13 different physiological races (0, 1, 12, 3, 13, … …American Journal of Agricultural and Biological Sciences, Vol. 3, Issue 1 · 31 Mar 2008 · 8,806 accessesView PDFCite
Research ArticleOpen accessIn the abstractSesame Oil As A Protective Agent Against Doxorubicin Induced Cardio Toxicity In RatKaneez F. Shad, Suhail Al-Salam, Alaaeldin A. HamzaThe therapeutic value of doxorubicin (DXO) as anticancer antibiotic is limited by its cardiotoxicity. This study aimed to investigate the protective effect of sesame oil against DXO-induced cardiotoxicity and oxidative stress. The administration of DXO (20 mg/kg) to Wister male rats, increased serum aspartate aminotransferase and creatine kinase activities (as cardiotoxicity indices) as well as cardiac malondialdehyde and protein carbonyl … …American Journal of Pharmacology and Toxicology, Vol. 2, Issue 4 · 31 Dec 2007 · 7,670 accessesView PDFCite
Research ArticleOpen accessIn the abstractAdvanced Oxidation Protein Products in Aged with DementiaMelike Erol Demirbilek, Nedret Kilic, H. Ferhan Komurcu, K. Okhan AkinThe role of increased oxidative stress in the development of oxidative protein damage in aging have been reported. There is an important role of oxidative stress on development of dementia. Advanced oxidation protein products (AOPPs) are novel markers of oxidative stress. The aim of this study was to compare AOPP levels in healthy aged person and aged person with dementia. … …American Journal of Immunology, Vol. 3, Issue 2 · 31 Dec 2007 · 7,256 accessesView PDFCite
Research ArticleOpen accessIn the abstractRole of Biopterin Transporter (BT1) Gene on Growth and Infectivity of LeishmaniaManju Jain, Vandana S. Dole, Peter J. Myler et al.Leishmania are known to be auxotrophic for pteridines that are known to play a critical role in the parasites survival. In the present work the role of biopterin transporter in the growth of the parasite and infectivity in to macrophages has been worked out. The role of biopterin transporter in the susceptibility of Leishmania to antimonial compounds has also been … …American Journal of Biochemistry and Biotechnology, Vol. 3, Issue 4 · 31 Dec 2007 · 7,038 accessesView PDFCite
Research ArticleOpen accessIn the abstractAssessment of Genotoxic Activity of Para-nitrophenol in Higher Plant Using Arbitrarily Primed- polymerase Chain Reaction (AP-PCR)Mohamed R. EnanParanitrophenol is a common toxic environmental pollutant; the aim of this study was to evaluate the potential of the DNA fingerprinting by AP-PCR assay to detect the DNA damage in the common bean (Phaseolus vulgaris) exposed to different concentrations of paranitrophenol (4.0-720 nM). The changes occurring in the fingerprint patterns were likely to be the result of paranitrophenol-induced DNA damage. … …American Journal of Biochemistry and Biotechnology, Vol. 3, Issue 2 · 30 Jun 2007 · 7,064 accessesView PDFCite
Research ArticleOpen accessIn the abstractBeta-2-Microglobulin in Autism Spectrum DisordersPaula Goines, Joseph Schauer, Luke Heuer et al.Autism spectrum disorders (ASD) are heterogeneous neurodevelopmental diseases of unknown etiology. There are no biological markers for ASD and current diagnosis is based on behavioral criteria. Recent data has shown that MHC I, a compound involved in adaptive immune function, is also involved in neurodevelopment, synaptic plasticity and behavior. It has been suggested that altered MHC I expression could play … …American Journal of Biochemistry and Biotechnology, Vol. 3, Issue 2 · 30 Jun 2007 · 7,560 accessesView PDFCite
Research ArticleOpen accessIn the abstractCirculating Granzymes are associated with Bloodstream Infection and Death in Febrile Medical PatientsAnnelies N. Tacx, Angela M. Wolbink, C. E. Hack, A.B. Johan GroeneveldPlasma levels of granzymes are specific markers for the activation of cytotoxic T lymphocytes and natural killer (NK) cells but the impact of activation of these cells on the course of bacterial infections is not well understood. We prospectively studied the implications of circulating granzyme A and B (GrA, GrB) levels in febrile, medical and hospitalized patients (n=284), during 3 … …American Journal of Infectious Diseases, Vol. 3, Issue 1 · 31 Mar 2007 · 6,736 accessesView PDFCite