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256 articles for “Genes”
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Research ArticleOpen accessIn the abstractInvestigations in the molecular events of Transitional Cell Carcinoma of the BladderH.S. Kadhim, A.S. Abdulamir, R.R. Hafidh et al.Problem Statement: Transitional Cell Carcinoma (TCC) of the bladder is a significant health problem worldwide. The molecular mechanisms of tumor development and progression are complicated but likely involve the interaction of tumor suppressor genes, oncogenes, cell cycle regulatory proteins and other factors. Hence this study tries to explore the role of p53, bcl-2, c-myc and Ki-67 in TCC of the … …American Journal of Biochemistry and Biotechnology, Vol. 4, Issue 4 · 31 Dec 2008 · 7,532 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Frequency of Polymorphisms affecting Lead and Mercury Toxicity among Children with AutismShannon Rose, Stepan Melnyk, Alena Savenka et al.Individual risk of developmental neurotoxicity with exposure to environmentally relevant levels of lead and mercury is likely to be determined by genetic susceptibility factors as well as additive interactions with other environmental pollutants, cumulative dose, and the developmental stage of exposure. The apparent increase in autism diagnosis over the last 15 years has enhanced interest in the possibility that an … …American Journal of Biochemistry and Biotechnology, Vol. 4, Issue 2 · 30 Jun 2008 · 7,524 accessesView PDFCite
Research ArticleOpen accessIn the abstractSignaling Pathways Involved In Dengue-2 Virus Infection Induced RANTES OverexpressionYing-Ray Lee, Huan-Yao Lei, Shun-Hua Chen et al.Dengue viruses participate in liver inflammation by inducting the expression of various chemokines including Regulated on Activation Normal T-cell Expressed and Secreted (RANTES). However, the underlying signaling remains unknown. Here, we reveal that Ras, Raf-1 and three mitogen-activated protein kinases (MAPKs) p38, extracellular signal-regulated kinase (Erk), and c-jun-NH2-terminal kinase (JNK) can be activated or phosphorylated in dengue-2 virus infected hepatocyte … …American Journal of Infectious Diseases, Vol. 4, Issue 1 · 31 Mar 2008 · 7,176 accessesView PDFCite
Research ArticleOpen accessIn the abstractGeographic Distribution and Genetic Analysis of Physiological Racesof Setosphaeria turcica in Northern ChinaJingao Dong, Yongshan Fan, Xiumei Gui et al.Five hundreds and forty-six isolates of Setosphaeria turcica, the causal agent of Northern Corn Leaf Blight, were collected in 61 corn-growing locations throughout six provinces of Northern China during 2000-2002, to determine their pathogenicity on two sets of host differentials: OH43/Huangzao4, OH43Ht1Huangzao4Ht1, OH43Ht2/Huangzao4Ht2, OH43Ht3/Huangzao4Ht3 and OH43HtN/Huangzao4HtN. The isolates were grouped into 13 different physiological races (0, 1, 12, 3, 13, … …American Journal of Agricultural and Biological Sciences, Vol. 3, Issue 1 · 31 Mar 2008 · 8,809 accessesView PDFCite
Research ArticleOpen accessIn the abstractTherapeutic Effects of Phyllanthus Species: Induction of TNF-α-mediated Apoptosis in HepG2 Hepatocellular Carcinoma CellsSripathi M. Sureban, Dharmalingam Subramaniam, Paramasivam Rajendran et al.Phyllanthus species, especially P. amarus is a medicinal plant with hepatoprotective activity, believed to occur in part by inhibiting hepatitis B virus function. The pathogenesis mechanism of viral hepatitis is closely related to hepatocyte necrosis apoptosis. The aim of our study was to investigate the in vitro effects of extracts from three Phyllanthus species, P. urinaria, P. amarus and P. … …American Journal of Pharmacology and Toxicology, Vol. 1, Issue 4 · 31 Dec 2007 · 9,009 accessesView PDFCite
Research ArticleOpen accessIn the abstractNutritional control of HIV-AIDS-A case for SeleniumParisa Kalantari, Hema Vunta, Umamaheswari D. Palempalli et al.Selenium (Se) is a micronutrient that is incorporated into proteins. Some of the selenoenzymes such as GPXs and thioredoxin reductases exhibit glutathione peroxidase-dependent activities towards organic and inorganic peroxides. Thus, selenoenzymes play a pivotal role in mitigating oxidative stress caused by accumulation of peroxides. In this respect, selenoproteins may interfere with the transcription-driven by oxidative stress-dependent signaling mechanisms to influence … …American Journal of Infectious Diseases, Vol. 3, Issue 4 · 31 Dec 2007 · 7,346 accessesView PDFCite
Research ArticleOpen accessIn the abstractIdentification and functional characterization of a novel lysine-rich protein from Entamoeba histolyticaAlka Mehra, Sudha Bhattacharya, Alok BhattacharyaIn an attempt to understand the role of genes with no known function, in the protozoan parasite Entamoeba histolytica, an analysis of the proteome was carried out and a Lysine-Rich protein (KRP) was identified for further study. This protein has a modular structure with four domains and was found to be expressed and localized to the cell surface of E. … …American Journal of Biochemistry and Biotechnology, Vol. 3, Issue 4 · 31 Dec 2007 · 7,709 accessesView PDFCite
Research ArticleOpen accessIn the abstractIdentification of Novel Chromosomal Abnormalities, inv(5)(p13q13) and t(7;18)(q32;q21), Associated with AutismZheng Chen, Xiao-bing Zou, Ya-nan Zhang et al.Autism is a neurodevelopmental disorder defined by impairments in social interaction, communication, as well as restricted and stereotyped behaviors. While the etiology of autism remains largely unknown, the existence of genetic components has been clearly demonstrated in autistic pathogenesis. The incidence of autism is 50-100 fold greater in the population with autistic family history than the general population. Chromosomal abnormalities … …American Journal of Biochemistry and Biotechnology, Vol. 3, Issue 3 · 30 Sep 2007 · 6,776 accessesView PDFCite
Research ArticleOpen accessIn the abstractA Novel Heat Shock Transcription Factor Family in Entamoeba histolyticaConsuelo G. García, Ma. De la Luz Macias Argüelles, D. Guillermo P Ishiwara et al.The HSTF is a master molecule involved in the transcriptional control of several genes during different types of stress. This transcription factor is a very conserved protein identified in different organisms from bacterial to human. Entamoeba histolytica is the protozoan responsible for the human amoebiasis. This parasite is exposed to different kind of stress as changes in the pH, temperature, … …American Journal of Infectious Diseases, Vol. 3, Issue 2 · 30 Jun 2007 · 7,186 accessesView PDFCite
Research ArticleOpen accessIn the abstractExpression of Thioredoxin-Fusion Proteins of α-Gliadin, γ-Gliadin and Low Molecular Weight Glutenin, from Wheat Endosperm and their Domains in EnterobacteriaClaudia G. Benitez-Cardoza, Yves Popineau, Jacques GueguenWheat seed storage proteins play a determining role in the viscoelastic properties of wheat gluten. The genes encoding α-gliadin, γ-gliadin and Low Molecular Weight glutenin and their N-central-repetitive and C-terminal domains from wheat endosperm had been subcloned into a thioredoxin expression system (pET102/D-Topo) and produced as fusion proteins in E. coli. The expression levels for each of the proteins varied … …American Journal of Infectious Diseases, Vol. 3, Issue 2 · 30 Jun 2007 · 6,748 accessesView PDFCite