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EditorialOpen accessIn the abstractImpact of Quantitative Pharmacology on Drug DevelopmentAna Ruiz-Garcia, Kourosh ParivarThesuccess of drug development rests over two well defined pillars, a goodunderstanding of the drug’s clinical pharmacology and the appropriate targetpopulation for whom the clinical use is intended. The label for human prescription drugsrequires a good understanding of the pharmacological effects (pharmacodynamicsor PD) and the mechanism of action of the drug as well as detailed informationof the drug’s Pharmacokinetics (PK): … …American Journal of Pharmacology and Toxicology, Vol. 9, Issue 4 · 24 Apr 2015 · 7,164 accessesView PDFCite
Research ArticleOpen accessIn the abstractBioinformatics Analysis of Xyloglucan Endotransglycosylase/Hydrolase (XTH) Gene from Developing Xylem of a Tropical Timber Tree Neolamarckia CadambaTiong Shing Yiing, Ho Wei Seng, Pang Shek Ling, Ismail JusohThis study reported the isolation and in silico characterization of a full-length Xyloglucan endotransglycosylase/Hydrolase (XTH) cDNA from Neolamarckia cadamba, an important tropical light hardwood plantation tree species. XTH is considered as a key agent to regulate cell wall expansion and is believed to be responsible for the incorporation of newly synthesised xyloglucan into the wall matrix. The full-length of NcXTH … …Current Research in Bioinformatics, Vol. 3, Issue 1 · 6 Jan 2015 · 7,431 accessesView PDFCite
Research ArticleOpen accessIn the abstractEMPIRICAL COMPARISON OF TWO METRICS SUITES FOR MAINTAINABILITY PREDICTION IN PACKAGES OF OBJECT-ORIENTED SYSTEMS: A CASE STUDY OF OPEN SOURCE SOFTWAREK.G. MadhwarajSoftware maintainability has been an important external quality attribute that concerns both styles of software development, the proprietary model as well as open source. As lots of open source software are predominantly built using the OO paradigm, there exists a need for empirical validation with respect to certain quality aspects especially maintainability. There are a few studies in the past … …Journal of Computer Science, Vol. 10, Issue 11 · 10 Dec 2014 · 8,218 accessesView PDFCite
Research ArticleOpen accessIn the abstractTHE CLINICAL APPLICATIONS FOR AUTOMATIC DETECTION OF EXUDATESK. Wisaeng, N. Hiransakolwong, E. PothirukNowadays, the retinal imaging technology has been widely used for segmenting and detecting the exudates in diabetic retinopathy patients. Unfortunately, the retinal images in Thailand are poor-quality images. Therefore, detecting of exudates in a large number by screening programs, are very expensive in professional time and may cause human error. In this study, the clinical applications for detection of exudates … …American Journal of Applied Sciences, Vol. 11, Issue 10 · 27 Sep 2014 · 6,451 accessesView PDFCite
Research ArticleOpen accessIn the abstractFUNCTIONAL SIMULATION PLATFORM FOR STUDYING UNDERWATER RADIATION PATTERNKanwarpreet Gilhotra, Nitaigour Premchand MahalikFor underwater communication, sound signals are used in contrast to RF. Recent development in wireless sensor network for underwater applications such as ocean exploration, marine aquaculture, sea animal tracking and so on have motivated the researchers and developers to understand the properties of sound signal within water in details. This study presents work on design and development of a simulation … …American Journal of Engineering and Applied Sciences, Vol. 7, Issue 3 · 12 Sep 2014 · 7,857 accessesView PDFCite
Research ArticleOpen accessIn the abstractMODELING OF FUTURE LAND COVER LAND USE CHANGE IN NORTH CAROLINA USING MARKOV CHAIN AND CELLULAR AUTOMATA MODELSayem M. Zaman, Manoj K. JhaState wide variant topographic features in North Carolina attract the hydro-climatologist. There is none modeling study found that predict future Land Cover Land Use (LCLU) change for whole North Carolina. In this study, satellite-derived land cover maps of year 1992, 2001 and 2006 of North Carolina were integrated within the framework of the Markov-Cellular Automata (Markov-CA) model which combines the … …American Journal of Engineering and Applied Sciences, Vol. 7, Issue 3 · 23 Aug 2014 · 8,718 accessesView PDFCite
Research ArticleOpen accessIn the abstractHOMOLOGY MODELING AND MOLECULAR DYNAMICS STUDIES OF EC1 DOMAIN OF VE-CADHERIN TO ELUCIDATE DOCKING INTERACTION WITH CADHERIN-DERIVED PEPTIDEVivitri Dewi Prasasty, Usman Sumo Friend Tambunan, Teruna Jaya SiahaanVE-cadherin is a protein in the cadherin family that is found at the adherens junctions of the microvessel endothelial cells of the Blood-Brain Barrier (BBB). It is recognized as the homotypic cell adhesion molecules and there is limited structural information on how VE-cadherins mediate cell-cell adhesion. It has been shown that the EC1 domain of cadherins is important for the … …OnLine Journal of Biological Sciences, Vol. 14, Issue 2 · 25 Jun 2014 · 7,534 accessesView PDFCite
Research ArticleOpen accessIn the abstractA NOVEL PRESSURIZED ZONAL MODEL USING THE MOMENTUM EQUATIONYao Yu, Ahmed Cherif MegriZonal models combine the simplicity of single and multi-zone models with the comprehensiveness of Computational Fluid Dynamics (CFD) models and thus become a better substitute to predict detailed thermal and airflow behaviors in building. Based on a geometric partitioning of a room into a number of subzones, these models give more accurate and detailed results than the single or multi-zone … …American Journal of Engineering and Applied Sciences, Vol. 7, Issue 1 · 25 Mar 2014 · 8,574 accessesView PDFCite
Research ArticleOpen accessIn the abstractCOMBINATION OF DIFFERENCE SUBSPACE AND OPPURTUNISTIC CLUSTERING ON HIGH DIMENSIONAL DATAM. Ravichandran, A. ShanmugamClustering is recognized as sigificant technique for analysing data and concentric effort has been taken in different domains comprises of recognition of pattern, statistical analysis and data mining for decades. Subspace clustering is developed from the group of cluster objects from all subspaces of a dataset. During clustering of objects involing higher dimension, the accuracy and effectiveness of traditional clustering … …Journal of Computer Science, Vol. 10, Issue 8 · 11 Mar 2014 · 6,359 accessesView PDFCite
Research ArticleOpen accessIn the abstractCOMBINATION OF CONVENTIONAL AND IN-SILICO APPROACH FOR IDENTIFYING AN INDUSTRIALLY IMPORTANT ISOLATE OF AEROMONASThungri Ghoshal, Sourav Ghosh, Amrita Saha et al.Ammonia is required for various commercial applications while its production by standard process is immensely energy intense. Dairy industry on the other hand produces huge volume of effluent needing treatment before discharge. This study aims at developing an eco-friendly microbial approach for conversion of dairy industry effluent into ammonia under atmospheric pressure and 37°C temperature at laboratory scale. Thus the … …OnLine Journal of Biological Sciences, Vol. 14, Issue 2 · 26 Feb 2014 · 7,926 accessesView PDFCite