Research ArticleOpen accessIn the abstractEvidence of Mitochondrial Dysfunction in Autism and Implications for TreatmentDaniel A. Rossignol, J. Jeffrey BradstreetClassical mitochondrial diseases occur in a subset of individuals with autism and are usually caused by genetic anomalies or mitochondrial respiratory pathway deficits. However, in many cases of autism, there is evidence of mitochondrial dysfunction (MtD) without the classic features associated with mitochondrial disease. MtD appears to be more common in autism and presents with less severe signs and symptoms. … …American Journal of Biochemistry and Biotechnology, Vol. 4, Issue 2 · 30 Jun 2008 · 16,373 accessesView PDFCite
Research ArticleOpen accessIn the abstractMitochondrial Energy-Deficient Endophenotype in AutismJ. Jay Gargus, Faiqa ImtiazWhile evidence points to a multigenic etiology of most autism, the pathophysiology of the disorder has yet to be defined and the underlying genes and biochemical pathways they subserve remain unknown. Autism is considered to be influenced by a combination of various genetic, environmental and immunological factors; more recently, evidence has suggested that increased vulnerability to oxidative stress may be … …American Journal of Biochemistry and Biotechnology, Vol. 4, Issue 2 · 30 Jun 2008 · 11,507 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Frequency of Polymorphisms affecting Lead and Mercury Toxicity among Children with AutismShannon Rose, Stepan Melnyk, Alena Savenka et al.Individual risk of developmental neurotoxicity with exposure to environmentally relevant levels of lead and mercury is likely to be determined by genetic susceptibility factors as well as additive interactions with other environmental pollutants, cumulative dose, and the developmental stage of exposure. The apparent increase in autism diagnosis over the last 15 years has enhanced interest in the possibility that an … …American Journal of Biochemistry and Biotechnology, Vol. 4, Issue 2 · 30 Jun 2008 · 7,521 accessesView PDFCite
Research ArticleOpen accessAll words, across the recordAnalysis of the Factors used by Farmers to Manage Risk. A Case Study on Italian FarmsAntonella Pontrandolfi, Fabian Capitanio, Felice Adinolfi, Barry GoodwinThe study analyses the strategies Italian farmers use to cope with the risks that face their production. We develop cross-sectional and longitudinal analyses as well as analyses of correlation that underline the main differences between the way farms adapt their structure and management towards risk. The expected output is an analysis of farms’ approach to risk management in relation to … …American Journal of Applied Sciences, Vol. 13, Issue 4 · 26 Apr 2016 · 7,633 accessesView PDFCite
Research ArticleOpen accessAll words, across the recordSTRESS; THE VULNERABILITY AND ASSOCIATION WITH DRIVING PERFORMANCEB. M.T. Shamsul, S. Khairunnisa, Y. G. Ng, M. Y. Irwan SyahSeveral factors may contribute to occurrence of road accidents which are human factors, vehicle factor, road factor and environmental factor. There has been recent evidence of a relationship between road accidents and emotional distress as well as fatigue. Monotonous and complex road environments are the road factor that relates to the internal factor within driver. The overall aim of this … …American Journal of Applied Sciences, Vol. 11, Issue 3 · 11 Jan 2014 · 7,717 accessesView PDFCite