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Research ArticleOpen accessEvery word in the titleHydrophobic, Polar and Hydrogen Bonding Based Drug-Receptor Interaction of TetrahydroimidazobenzodiazepinonesV.K. Sahu, A.K.R. Khan, R.K. Singh, P.P. SinghAnti-HIV drug discovery has been increasingly focusing on HIV-1-RT (reverse transcriptase) as a potential therapeutic target. Tetrahydroimidazobenzodiazepinone (TIBO) belongs to non-nucleoside group of reverse transcriptase inhibitors (NNRTIs). A computational chemistry study has been performed on a series of tetrahydroimidazo-benzodiazepinones as HIV-1-NNRT inhibitors. Problem statement: In order to search out new drug of desired activity from the lead compounds, there was … …American Journal of Immunology, Vol. 4, Issue 3 · 30 Sep 2008 · 8,837 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleTransition Metal Complexes of Derivatized Chiral Dihydro-1,2,4-triazin-6-ones. Template Synthesis of Nickel(II) Tetraaza-(4N-M) Complexes Incorporating the Triazinone MoietyAhmad S. Abushamleh, Marwa M. Al-Aqarbeh, Vector DayTemplate reactions of (L)-3-acetyl-5-methyl-1-phenyl-4,5-dihydro-1,2,4-triazine-6- one (8a) or (L)-3-acetyl-5-benzyl-1-phenyl-4,5-dihydro-1,2,4-triazine-6-one (8b) with nickel(II) acetate in the presence of a suitable diamine such as: 1,3-diaminopropane, o-phenylenediamine, or ethylenediamine afforded square planar tetraaza nickel(II) complexes of the type 4N-M (Scheme 4). Single crystal X-ray structural analysis of one of the complexes (9b) revealed square planar geometry around the nickel ion and symmetrical coordination of … …American Journal of Applied Sciences, Vol. 5, Issue 6 · 30 Jun 2008 · 7,368 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleCreation of Tetracycline Regulatable Knockouts of ORFF Gene from the LD1 Locus of Leishmania donovaniBindu Sukumaran, Manju Jain, Peter J. Myler et al.The tetracycline repressor/operator system was adapted for use in Leishmania donovani. In order to investigate the possible importance and function of open reading frame F (ORFF) in Leishmania donovani strain AG83 that has a single copy of ORFF in the LD1 locus on chromosome 35, we have attempted to generate tetracycline regulatable single allele mutants of ORFF. Leishmania cells expressing … …American Journal of Biochemistry and Biotechnology, Vol. 3, Issue 4 · 31 Dec 2007 · 6,829 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleSynthesis of Sodium Salt of 3,6-Dibutanoic-1,2,4,5-TetroxaneEduardo A. Castro, Soledad Bustillo, Jorge M. Romero et al.We report the experimental preparation of the sodium salt of 3,6-dibutanoic-1,2,4,5- tetroxane by addition of saturate solution of sodium hydroxide to the 3,6-dibutanoic-1,2,4,5-tetroxane, synthesized following the method modified by Jorge et al. The UV and IR spectra were studied from the experimental standpoint. A rather complete vibrational assignment was performed and the nature of the electronic transitions was discussed in … …American Journal of Biochemistry and Biotechnology, Vol. 1, Issue 1 · 31 Mar 2005 · 6,638 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleAnticancer Activity of Some New Synthesized Tetrahydroquinoline and Tetrahydrochromene Carbonitrile DerivativesUsama W. Hawas, Mohamed A. Al-Omar, Abd El-Galil E. Amr, Abu El-Ftouh G. HammamProblem statement: In continuation to our search for new heterocyclic chemistry based anticancer, the suggestion, synthesis, structure elucidation of some naphthalene, chromene and quinoline derivatives 3-7 were realized herein using 3-methylcyclohexanone 1 as a starting material. Approach: The antitumor activities of the newly synthesized compounds 4-7 were evaluated utilizing 60 different human tumor cell lines, representing leukemia, melanoma, lung, colon, … …American Journal of Applied Sciences, Vol. 8, Issue 10 · 14 Sep 2011 · 7,484 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleConformational Analysis of Trans-3, 6-Dibutanal-1, 2, 4, 5-TetroxaneEduardo A. Castro, Mariela I. Profeta, Jorge M. Romero et al.We report the results of theoretical semiempirical AM1 and PM3 molecular orbital methods on the conformational analysis of the title compound. The relative stability of different isomers and conformers are discussed on the basis of well defined electronic and steric effects, which are rather helpful in order to understand the relative stabilities. …American Journal of Biochemistry and Biotechnology, Vol. 1, Issue 1 · 31 Mar 2005 · 6,695 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleIn Vitro Biological Profiles and Chemical Contents of Ethanolic Nest Entrance Extracts of Thai Stingless Bees Tetrigona apicalisTouchkanin Jongjitvimol, Sathirapong Kraikongjit, Pussadee Paensuwan, Jirapas JongjitwimolTetrigona apicalis is a species of stingless bees found in Lower Northern Thailand. They normally construct their nest entrances as an external structure for protecting themselves from enemies. Their biological properties have not well characterized yet. The objectives of this study were to evaluate the antibacterial, antifungal and anti-proliferative activities of their nest entrances. Samples were collected from four provinces … …OnLine Journal of Biological Sciences, Vol. 20, Issue 3 · 2 Nov 2020 · 6,781 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleHepatoprotective Impact Of TLR9 Antagonist ODN 2088 Against Carbon Tetrachloride (CCl4)-Induced Hepatic InjuryBadr AlzahraniThe main objective of this study is to evaluate the hepatoprotective impact of TLR9 antagonist ODN 2088 against carbon tetrachloride (CCl4)-induced acute liver injury. In this study, 24 mice were grouped into four groups. CCl4 was introduced in all groups except for the control group intraperitoneally after pretreatment with ODN 2088 and silymarin for seven days. To assess the liver … …American Journal of Biochemistry and Biotechnology, Vol. 16, Issue 1 · 4 Jan 2020 · 7,659 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleHepatoprotective Effect of Opuntia Ficus-Indica Aqueous Extract against Carbon Tetrachloride-Induced Toxicity in RatsZouhir Djerrou, Zineb Maameri, Sihem Halmi et al.The present study was undertaken to evaluate the hepatoprotective activity of Opuntia ficus-indicaL. aqueous extract. About 24 Wistar male rats were divided randomly to 4 groups of 6 each. The 1st was given distilled water and served as normal control (CRL). The 2nd was intoxicated orally with carbon tetrachloride at a dose of 1.5 mL/kg each 72 h (CCl4 group) … …OnLine Journal of Biological Sciences, Vol. 15, Issue 2 · 2 Jun 2015 · 7,254 accessesView PDFCite