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Review ArticleOpen accessIn the keywordsMicroRNA-92a: The Administrator of Certain DiseasesZhiyuan Sun, Qing Xu, Xiaoyi Tian et al.MicroRNA-92a (miR-92a) is an evolutionarily conserved noncoding small RNA that can regulate gene expression after transcription. Previous studies have found that miR-92a is overexpressed in many tumors and can regulate numerous tumor suppressor genes negatively, with relevant effects on the development of different tumors, by regulating the DUSP10/c-Jun N-terminal kinase (JNK), phosphatase and tensin homologs (PTEN)/AKT, Wnt and EP4/Notch1 signaling … …American Journal of Biochemistry and Biotechnology, Vol. 16, Issue 2 · 21 May 2020 · 6,494 accessesView PDFCite
Research ArticleOpen accessIn the keywordsIdentification of Long Non-coding RNAs Expressed During Early AdipogenesisRongkun Shen, Rachel A. Soeder, Henry D. Ophardt et al.Long non-coding RNAs (lncRNAs) are transcripts with a length of more than 200 nucleotides that lack protein-coding capacity. LncRNAs play important roles in the regulation of genes during many biological processes, development and disease progression, such as obesity. Obesity is an increasing health concern around the world. Although multiple studies linking lncRNAs and fully differentiated adipocytes have been published, the … …OnLine Journal of Biological Sciences, Vol. 19, Issue 4 · 30 Nov 2019 · 7,823 accessesView PDFCite
Research ArticleOpen accessIn the keywordsSex Dimorphism in the Fgf21 Gene Expression in Liver and Adipose Tissues is Dependent on the Metabolic ConditionNadezhda Bazhan, Tatiana Jakovleva, Natalia Balyibina et al.Fibroblast growth factor-21 (FGF21) beneficially affects carbohydrate and lipid metabolism. Previously, a sex-specific activation of Fgf21 expression was observed in humans and animals with metabolic diseases. It is unknown whether the sex differences in the Fgf21 expression are manifested in response to the natural physiological situations of fasting and refeeding. The aim of this work was to determine liver, White … …OnLine Journal of Biological Sciences, Vol. 19, Issue 1 · 29 Jan 2019 · 8,153 accessesView PDFCite
Research ArticleOpen accessIn the keywordsImmunological Processes in Cancer: A Link Between Inflammation and ImmunityVanessa Jacob Victorino, Isabela Casagrande Jeremias, Anne Karine Martins AssunçãoCancer is a worldwide issue and one of the most relevant death causes in child and adults. There are several causes that can lead to cancer development. It is well known that inflammation is one known hallmark of cancer and it favors tumor cells growth. Several alterations in immunological and inflammatory processes are caused in response to tumor presence and … …American Journal of Immunology, Vol. 10, Issue 4 · 17 Jan 2015 · 7,073 accessesView PDFCite
Research ArticleOpen accessIn the keywordsIMMUNOLOGICAL PROCESSES IN CANCER: A LINK BETWEEN INFLAMMATION AND IMMUNITYVanessa Jacob Victorino, Isabela Casagrande Jeremias, Anne Karine Martins AssunçãoCancer is a worldwide issue and one of the most relevant death causes in child and adults. There are several causes that can lead to cancer development. It is well known that inflammation is one known hallmark of cancer and it favors tumor cells growth. Several alterations in immunological and inflammatory processes are caused in response to tumor presence and … …American Journal of Immunology, Vol. 10, Issue 2 · 5 Jun 2014 · 6,941 accessesView PDFCite
Research ArticleOpen accessIn the keywordsHormesis and Exercise: How the Cell Copes with Oxidative StressLi Li Ji, Zsolt Radak, Sataro GotoContraction-induced production of reactive oxygen and nitrogen species has been shown to cause oxidative stress to skeletal muscle, heart and other organs. As an adaptive response, muscle antioxidant defense systems are upregulated in response to exercise to restore intracellular prooxidantantioxidant homeostasis. Thus, both young and old animals and humans involved in regular exercise have shown reduced oxidative damage during acute … …American Journal of Pharmacology and Toxicology, Vol. 3, Issue 1 · 31 Mar 2008 · 7,817 accessesView PDFCite
Research ArticleOpen accessIn the keywordsRedox Sensing and Cardiac Myocyte Loss: Some Recent InsightsShyamal K. GoswamiGeneration of reactive oxygen-nitrogen species (ROS/RNS) has long been ascribed to pathophysiological conditions like ageing, neurodegenerative and cardiovascular disorders. However, more recent evidences suggest that while generation of ROS/RNS at a higher threshold is deleterious, at a lower dose these can act as second messengers, influencing specific cellular events like cell growth and differentiation, embryonic development, protection against ischemic injuries … …American Journal of Biochemistry and Biotechnology, Vol. 3, Issue 4 · 31 Dec 2007 · 6,349 accessesView PDFCite
Research ArticleOpen accessIn the keywordsAn Improved Resource Reservation ProtocolDesire Oulai, Steven Chamberland, Samuel PierreThe classical resource reservation protocol (RSVP) is a flow-based signaling protocol used for reserving resources in the network for a given session. RSVP maintains state information for each reservation at every router along the path. Even though this protocol is very popular, he has some weaknesses. Indeed, RSVP does not include a bidirectional reservation process and it requires refresh messages … …Journal of Computer Science, Vol. 3, Issue 8 · 31 Aug 2007 · 6,488 accessesView PDFCite
Review ArticleOpen accessIn the abstractJAK Inhibitors for Rheumatoid Arthritis: Assessing Efficacy and Safety in TreatmentAnastasia V. Poznyak, Varvara A Orekhova, Natalia Vladimirovna Elizova et al.Rheumatoid Arthritis (RA) is a chronic autoimmune disease characterized by synovial inflammation, progressive joint destruction, and systemic complications. Dysregulated cytokine signaling through the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway plays a central role in RA pathogenesis, making JAK inhibitors an important therapeutic option. Tofacitinib, baricitinib, and upadacitinib are oral targeted synthetic disease-modifying antirheumatic drugs that interfere with … …OnLine Journal of Biological Sciences, Vol. 26, Issue 4 · 8 Oct 2026 · 412 accessesView PDFCite
Research ArticleOpen accessIn the abstractExploring the Relationship Between Skin Barrier Function, Sensitivity, and Repair MechanismsXiaoqing Yan, Yusong Shi, Jiguang YangFor healthy skin, the skin's barrier function must remain maintained. Many different molecular while immunological signaling mechanisms are involved in skin barrier control. The control of a healthy skin barrier, particularly acid mantle maintenance and proper amounts of ceramides, may help dermatologists develop remedies for skin barrier disruption disorders. In contrast, new medicines could focus on signaling pathways to offer … …American Journal of Biochemistry and Biotechnology, Vol. 21, Issue 4 · 15 Feb 2026 · 1,893 accessesView PDFCite