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Research ArticleOpen accessIn the keywordsAnticancer Activity of Some New Synthesized Tetrahydroquinoline and Tetrahydrochromene Carbonitrile DerivativesUsama W. Hawas, Mohamed A. Al-Omar, Abd El-Galil E. Amr, Abu El-Ftouh G. HammamProblem statement: In continuation to our search for new heterocyclic chemistry based anticancer, the suggestion, synthesis, structure elucidation of some naphthalene, chromene and quinoline derivatives 3-7 were realized herein using 3-methylcyclohexanone 1 as a starting material. Approach: The antitumor activities of the newly synthesized compounds 4-7 were evaluated utilizing 60 different human tumor cell lines, representing leukemia, melanoma, lung, colon, … …American Journal of Applied Sciences, Vol. 8, Issue 10 · 14 Sep 2011 · 7,484 accessesView PDFCite
Research ArticleOpen accessIn the keywordsAnticancer Activities of Some New Synthesized Thiazolo[3,2-a]Pyrido[4,3-d]Pyrimidine DerivativesAshraf M. Mohamed, Abdel-Galil E. Amr, Musaed A. Alsharari et al.Problem statement: This study describes the synthesis and anticancer activities of a new series of thiazolo[3,2-a]pyrimidines derivatives (2-7) using 3,5-bisarylmethylene-1-methyl-4- piperidone and 4-aryl-8-arylmethelene-6-methylpyrido[4,3-d]pyrimidine-2(1H)thiones as a starting materials. Approach: The antitumor activities of the newly synthesized compounds 4-7 were evaluated utilizing 60 different human tumor cell lines, representing leukemia, melanoma, lung, colon, brain, ovary, breast and prostate as well as kidney. … …American Journal of Biochemistry and Biotechnology, Vol. 7, Issue 2 · 23 Aug 2011 · 10,087 accessesView PDFCite
Research ArticleOpen accessIn the abstractOne can Achieve the Nuclear Fission Reaction of Lithium by Accelerated Hydrogen Nuclei or NeutronsRelly Victoria Virgil Petrescu, Florian Ion Tiberiu PetrescuThe idea circulated among physicists that in the upper area of the physical elements the fission reaction can be obtained and in the lower one the fusion reaction occurs. In the presented paper we want to impose another rule, namely the obtaining in the lower part of the physical elements of the fission and fusion nuclear reactions, with the obvious … …American Journal of Engineering and Applied Sciences, Vol. 14, Issue 3 · 7 Sep 2021 · 9,516 accessesView PDFCite
Research ArticleOpen accessIn the abstractCoupling Analysis of Thermodynamic Equilibrium of Mass Transfer and Microbial Community Succession in Multiphase System of Dark Tea Solid-State FermentationZhanjun Liu, Jiawei Sun, Taotao Li et al.During the solid-state fermentation of dark tea, the limited material migration, the dynamic evolution of the thermodynamic equilibrium state, and the highly dynamic succession of the microbial community make it difficult to analyze the quality formation mechanism systematically. Traditional research has focused on microbial diversity or sensory quality analysis, lacking a systematic discussion on the regulatory effects of material migration … …American Journal of Biochemistry and Biotechnology, Vol. 22, Issue 3 · 10 Aug 2026 · 1,004 accessesView PDFCite
Review ArticleOpen accessIn the abstractAssessing Protein PurityShiva Siddappa, Liang-Yin Ke, Chu-Huang Chen, Gopal Kedihithlu MaratheDetermination of protein purity is crucial, as proteins are frequently used as therapeutic agents and reagents in many biochemical reactions. Additionally, purified protein is necessary for biophysical and structural studies. Assessing protein purity involves examining for impurities or demonstrating their absence. In our experience, a satisfactory answer is seldom obtained when biochemistry students are asked a common question on how … …American Journal of Biochemistry and Biotechnology, Vol. 21, Issue 4 · 9 Feb 2026 · 1,901 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Impact of Changes in Forage Vegetation for Saiga (Saiga Tatarica) On Natural Pastures in The Steppe Zone of the West Kazakhstan RegionAmanay Myrzabayev, Zhanbolat Ibraibekov, Zhangeldi Ussenov et al.This study investigates the impact of recent climate changes and reduced anthropogenic pressure on the vegetation cover in the steppe regions of Russia and Kazakhstan, particularly focusing on the effects on saiga (Saiga tatarica) populations. By the late 1990s, a significant shift towards the dominance of grasses and the reduction of herbaceous plants in semi-arid and arid regions was observed, … …OnLine Journal of Biological Sciences, Vol. 25, Issue 4 · 7 Feb 2026 · 1,765 accessesView PDFCite
Research ArticleOpen accessIn the abstractOptimization of α-Glucosidase Inhibitors Recovery from Rainbow Trout Hydrolysate Using GA-BP Neural NetworkYingke Chu, Yanling Dong, Qingfeng Rong et al.To enhance the value of by-products from rainbow trout processing, the inhibition rate of α-glucosidase (AGIR) is used as indicators. Optimization of rainbow trout hydrolysate extraction by comparing Response Surface Methodology (RSM) and BP Neural Network (BPNN) models. The RSM results: the AGIR is 55.02%. BPNN models predicted the optimal extraction conditions: 51℃ for temperature,1:2.3 for solid-liquid ratio, 4.15 h … …American Journal of Biochemistry and Biotechnology, Vol. 21, Issue 3 · 28 Jan 2026 · 1,734 accessesView PDFCite
Case ReportOpen accessIn the abstractA Reasonable Outcome with Systemic Corticosteroids in a Case of Ibuprofen Induced Stevens-Johnson SyndromeElif Güdeloğlu, Volkan Emir AltanBoth Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are idiosyncratic severe mucocutaneous reactions, usually to drugs or infections, characterized by blistering and epithelial sloughing. Although rare, SJS and TEN are destructive diseases; in serious cases the acute phase may be followed by a variety of systemic complications, including multiorgan failure and death. Ibuprofen is a universal antipyretic and analgesic … …American Journal of Immunology, Vol. 16, Issue 1 · 4 Sep 2020 · 7,451 accessesView PDFCite
Research ArticleOpen accessIn the abstractExploring the Role of Vitamin B12 as an Anti-atherogenic and Anti-inflammatory Agent in Apparently Healthy Adults With Hypovitaminosis DShravan Ajith Panchwadkar, Sudha Kuthethur, Sowndarya Kollampare, Neelam Manjunath PawarVitamin B12 deficiency is associated with metabolic changes like methyl malonic acidemia and hyperhomocystinemia eventually leading to atherosclerosis. Dyslipidemia and vitamin D (vit D) deficiency are independent risk factors of CVD. This study aims to explore the interrelationship between inflammatory markers, adverse lipid profile and vitamin B12 in hypovitaminosis D. Since, atherosclerosis is an inflammatory condition we have investigated CRP … …OnLine Journal of Biological Sciences, Vol. 25, Issue 3 · 11 Jul 2025 · 3,326 accessesView PDFCite
Research ArticleOpen accessIn the abstractGenetic Diversity in Merozoite Surface Protein.1 of Plasmodium falciparum in Highlands: Wamena Papua IndonesiaRosye Hefmi Rechnelty Tanjung, Yulius Sarungu, Meidy Johana Imbiri et al.Malaria is the first killer as well as endemic disease in highland, lowland and coastal areas of Papua. In 2016 there were 160 thousands cases noted and 80% of the cases were caused by Plasmodium falciparum. Total sample for this study were provided by a clinical trial conducted from May to June 2018 in the regional hospital of Puncak Jaya, … …American Journal of Infectious Diseases, Vol. 14, Issue 4 · 11 Jan 2019 · 7,753 accessesView PDFCite