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92 articles for “polymerase”
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Research ArticleOpen accessEvery word in the titleMolecular Dynamics Simulation of DENV RNA-Dependent RNA-Polymerase with Potential Inhibitor of Disulfide Cyclic PeptideUsman Sumo Friend Tambunan, Raima Syahidah Noors, Arli Aditya Parikesit et al.Problem statement: Our researches have proposed two ligands of disulfide cyclic polypeptide, which are CDEEC and CDGSC as potential inhibitor of DENV RNA-dependent RNApolymerase by molecular docking. Approach: Methodological approach was conducted to determine the best ligand to act as inhibitor. Molecular docking simulation was conducted without a solvent in which enzyme was made rigid and ligand was left free … …OnLine Journal of Biological Sciences, Vol. 11, Issue 2 · 30 Sep 2011 · 8,441 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleAssessment of Genotoxic Activity of Para-nitrophenol in Higher Plant Using Arbitrarily Primed- polymerase Chain Reaction (AP-PCR)Mohamed R. EnanParanitrophenol is a common toxic environmental pollutant; the aim of this study was to evaluate the potential of the DNA fingerprinting by AP-PCR assay to detect the DNA damage in the common bean (Phaseolus vulgaris) exposed to different concentrations of paranitrophenol (4.0-720 nM). The changes occurring in the fingerprint patterns were likely to be the result of paranitrophenol-induced DNA damage. … …American Journal of Biochemistry and Biotechnology, Vol. 3, Issue 2 · 30 Jun 2007 · 7,064 accessesView PDFCite
Short CommunicationsOpen accessIn the keywordsMolecular Testing for Respiratory Tract Infections May Have Favorable Impact on Real-world Healthcare CostsAzia Evans, Vijay Singh, Pallavi Upadhyay et al.Molecular testing by Polymerase Chain Reaction (PCR) has improved diagnostic performance to inform appropriate treatment. However, its impact on healthcare utilization and costs related to respiratory tract infections are yet to be studied in detail. The aim of this study is to evaluate the costs of healthcare utilization following traditional culture and molecular PCR diagnostic testing for respiratory tract infections. … …American Journal of Infectious Diseases, Vol. 20, Issue 3 · 15 Jan 2025 · 5,262 accessesView PDFCite
Research ArticleOpen accessIn the keywordsAn Observational Study on the Prevalence of Sexually Transmitted Infections in Cheonan from 2017 to 2021Sun Jung Lee, Tae Su Jang, Jae Kyung KimAlthough the global incidence of sexually transmitted infections is increasing annually, there are few studies in Cheonan that have analyzed the frequency of infection by individual bacterial species by age since 2017. Therefore, in this observational study, we investigated trends in sexually transmitted infections in Cheonan, South Korea, since 2017. From January 2017 to November 2021, 3,297 specimens were obtained … …American Journal of Biochemistry and Biotechnology, Vol. 20, Issue 2 · 17 Apr 2024 · 6,316 accessesView PDFCite
Research ArticleOpen accessIn the keywordsThe Underestimated Prevalence of Ureaplasma Infections: A Comprehensive Epidemiological Study in South Korea (2018-2020)Jae Eun Choi, Bo Kyeung Jung, Eun Ju Oh, Jae Kyung KimUreaplasma infections are frequently underestimated due to potential inaccuracies in data collection from symptomatic patients. This study aimed to accurately assess the prevalence of Ureaplasma Urealyticum (UU) and Ureaplasma Parvum (UP) infections among outpatients aged 0-70 years in South Korea between 2018 and 2020. A total of 59,381 clinical samples, including swabs and urine specimens, were collected and analyzed using … …American Journal of Biochemistry and Biotechnology, Vol. 20, Issue 1 · 25 Mar 2024 · 6,130 accessesView PDFCite
Letter to the EditorOpen accessIn the keywordsSofosbuvir May be a Potential Anti-SARS-CoV-2 RdRp DrugMohamed Nabil Ibrahim, Abdo Abdellah ElfikyThe Coronavirus Diseases 2019 (COVID-19) seriously affecting human health all over the world. More than 107 M people are reported positive for SARS-CoV-2, the virus causing COVID-19 pneumonia, from which +2.3 M died. Nucleotide Inhibitors (NI) have promising results in terms of its efficacy against different viral polymerases, including the Hepatitis C Virus (HCV) Non-Structural Protein 5 B (NS5B) RNA … …American Journal of Biochemistry and Biotechnology, Vol. 17, Issue 2 · 10 May 2021 · 6,568 accessesView PDFCite
Research ArticleOpen accessIn the keywordsOccurrence of Feline Immunodeficiency Virus (FIV) and Feline Leukemia (FeLV) in São Luís-MANathálya dos Santos Martins, Ana Paula Sousa Rodrigues, Stefanne Aparecida Gonçalves et al.The aim of this study was to evaluate the occurrence of feline immunodeficiency virus and feline leukemia virus in the city of São Luí­s, Maranhão state (MA), Brazil. A total of 120 blood samples were tested using the Polymerase Chain Reaction (PCR) to detect the proviral DNA, with an amplification of a fragment of 244bp of the FIV's gene gag. … …American Journal of Animal and Veterinary Sciences, Vol. 10, Issue 3 · 24 Jul 2015 · 8,944 accessesView PDFCite
Research ArticleOpen accessIn the keywordsSerological and Molecular Investigation of Cutaneous Leishmaniasis in Healthy Individuals from an American Cutaneous Leishmaniasis-Endemic RegionRejane Cristina Ribas-Silva, Taisa Rocha Navasconi, Laís de Souza Braga et al.American Cutaneous Leishmaniasis (ACL) is a major, clinically relevant zoonosis in Brazil. The disease spectrum includes single, localized, cutaneous ulcers, diffuse cutaneous leishmaniasis and mucosal disease. A subclinical form of the disease has also been described in individuals living in ACL-endemic regions. The goal of this study was to employ immunological and molecular diagnostic methods to evaluate the presence of … …American Journal of Infectious Diseases, Vol. 11, Issue 1 · 23 Jun 2015 · 7,324 accessesView PDFCite
Research ArticleOpen accessIn the keywordsStructural and Evolutionary Analysis of PARPs in D. discoideumA. Mehadvi Kawal, Hina A. Mir, Chethan Kumar Ramniklal et al.Problem statement: Dictyostelium discoideum, a unicellular eukaryote, exhibits multicellularity upon nutrient starvation, making it a better model for developmental studies and for the study of various signal transduction pathways. The most felicitous point of interest is that many of its genes show high degree of similarity to vertebrate genes. Poly (ADP-ribose) polymerase (PARP), a ubiquitous and abundant nuclear protein, has … …American Journal of Infectious Diseases, Vol. 7, Issue 3 · 3 Nov 2011 · 7,852 accessesView PDFCite
Research ArticleOpen accessIn the keywordsOccurrence of Feline Immunodeficiency Virus and Feline Leukemia Virus Infection in CatsFabiana Alves, Daniela de Souza Rajao, Helen Lima Del Puerto et al.Problem statement: The objective of the present study was to evaluate occurrence of the Feline Immunodeficiency Virus (FIV) and the Feline Leukemia Virus (FeLV) infection in asymptomatic domestic cats in the metropolitan region of Belo Horizonte, Minas Gerais, using the Polymerase Chain Reaction (PCR) for FIV detection and SNAP Combo Plus for FeLV and FIV detection. Approach: Blood samples were … …American Journal of Animal and Veterinary Sciences, Vol. 6, Issue 3 · 2 Nov 2011 · 8,717 accessesView PDFCite