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19 results for “pharmaceutical compounds”
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Research ArticleOpen accessIn the abstractFrequency of Single Nucleotide Polymorphisms of the SLCO1B1 Gene in Slavic Population of Central EuropeMichaela Mikulová, Veronika Kramarova, Ján ChandogaThe organic anion transporting polypeptide 1B1 (encoded by SLCO1B1 gene) is involved in the active cellular influx of diverse endogenous compounds and several drugs, such as HMG-CoA reductase inhibitors (statins). Two common polymorphisms c.388A>G and c.521T>C in SLCO1B1 alter transport activity of this transporter and play an important role in the pharmaceutical response to many drugs. The aim of our … …OnLine Journal of Biological Sciences, Vol. 16, Issue 4 · 11 Dec 2016 · 7,308 accessesView PDFCite
Research ArticleOpen accessIn the abstractAntimicrobial and Antioxidant Activities of Bacterial Extracts from Marine Bacteria Associated with Sponge Stylotella sp.Daning Yoghiapiscessa, Irmanida Batubara, Aris Tri WahyudiSponge-associated bacteria have great potential in developing marine pharmaceutical industry since they are capable of synthesizing numerous bioactive metabolite compounds. This study aimed to isolate, characterize and investigate potential antimicrobial, toxicity and antioxidant of bioactive compounds of bacteria associated with sponge Stylotella sp. A total of 138 bacteria were selected. During screening stage, 45 isolates (32%) produced a wide spectrum … …American Journal of Biochemistry and Biotechnology, Vol. 12, Issue 1 · 22 Feb 2016 · 9,154 accessesView PDFCite
Research ArticleOpen accessIn the abstractAnalysis of Phenolic Content and Antioxidant Properties of Selected Cowpea Varieties Tested in Bovine Peripheral BloodSarah Adjei-Fremah, Louis EN Jackai, Mulumebet WorkuCowpea is an important grain legume with a dual purpose function as a food and feed resource. Cowpea contains phenolic compounds that are beneficial to human and animal health. We evaluated the phenolic content, condensed tannin content and antioxidant capacities of methanol extracts of seed and leaf of seven varieties commonly used in food and animal feed. The total phenolic … …American Journal of Animal and Veterinary Sciences, Vol. 10, Issue 4 · 19 Dec 2015 · 7,870 accessesView PDFCite
Research ArticleOpen accessIn the abstractOptimization of Total Phenolic from Cleistocalyx nervosum by Microwave-Assisted ExtractionNukrob Narkprasom, Kanjana Narkprasom, Umaporn UparaThe objective of this research was to extract phenolic compounds from Makiang (Cleistocalyx nervosum) seeds waste obtained from the elaboration of makiang beverages using the microwave assisted extraction method. The optimal conditions of microwave assisted extraction of total phenolics from makiang seeds were determined using response surface method. The variables of microwave power, extraction time and ethanol proportion on effect … …American Journal of Engineering and Applied Sciences, Vol. 8, Issue 3 · 29 May 2015 · 8,097 accessesView PDFCite
Research ArticleOpen accessIn the abstractComparative Docking Analysis on Natural Compounds Versus a Synthetic Drug as a Therapeutic for Acquired Immuno Deficiency SyndromeSandhya R. Nair, R. Subhashini, B. ThiagarajanProblem statement: Acquired Immune Deficiency Syndrome (AIDS) is one of the worst pandemics affecting and spreading quickly all over the world with a high mortality rate. AIDS has been able to kill so many people due to the unique property of Human Immunodeficiency Virus (HIV) virus. It attacks the immune system of the victim there by not allowing the immune … …Current Research in Medicine, Vol. 1, Issue 2 · 31 Oct 2010 · 7,323 accessesView PDFCite
Research ArticleOpen accessIn the abstractQuercetin, Quercetrin Except Rutin Potentially Increased Pirarubicin Cytotoxicity by Non-Competitively Inhibiting the P-Glycoprotein-and MRP1 Function in Living K562/adr and GLC4/adr CellsWinit Choiprasert, Nathupakorn Dechsupa, Suchart Kothan et al.Problem statement: Quercetin and its glycoside derivatives are increasingly receiving interests as new generation of anticancer molecules and were recognized by multidrug resistant transporters such as P-glycoprotein and MRP1 protein. Of relevance to their use as anticancer agents alone or in combination with other agents, this study aims to analyze the interaction of the compounds with the MDR transporters including … …American Journal of Pharmacology and Toxicology, Vol. 5, Issue 1 · 31 Mar 2010 · 9,670 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Inhibition of Human Pathogens: Trichophyton rubrum and Trichoderma harzianum by a Natural ProductRand R. Hafidh, A.S. Abdulamir, Law Se Vern, Fatimah Abu BakarProblem statement: A number of studies have recently conducted to identify novel and potent antifungal components from natural products. One of the reasons is to overcome the antifungal resistant developed against most of commercially available drugs. Studies confirmed that mung beans have increased phenolic compounds and enhanced defenses during germination. Approach: We hypothesized that antifungal activities might be found in … …American Journal of Biochemistry and Biotechnology, Vol. 6, Issue 1 · 31 Mar 2010 · 9,361 accessesView PDFCite
Research ArticleOpen accessIn the abstractDetermination of Ibuprofen and Paracetamol in Binary Mixture Using Chemometric-Assisted Spectrophotometric MethodsWafaa S. HassanThree methods are presented for simultaneous determination of ibuprofen and paracetamol without previous separation. The first method depends on first derivative UV spectrophotometry, with zero-crossing measurement. The first derivative amplitudes at 230 and 290 nm were selected for the assay of ibuprofen and paracetamol, respectively. The second method depends on first derivative of the ratio-spectra by measurements of the amplitudes … …American Journal of Applied Sciences, Vol. 5, Issue 8 · 31 Aug 2008 · 8,199 accessesView PDFCite
Research ArticleOpen accessIn the abstractDetermination of Diloxanide Furoate and Metronidazole in Binary Mixture Using First Derivative of the Ratio-Spectra and High-Performance Liquid Chromatography-UV MethodsNora H. Al-ShaalanTwo methods are presented for simultaneous determination of diloxanide furoate and metronidazole. The first method depends on first derivative of the ratio-spectra by measurements of the amplitudes at 242.5 and 285.5 nm for diloxanide furoate and 225.5 and 300 nm for metrinidazole. Calibration graphs were established for 2-100 μg mL-1 for diloxanide furoate and 1-50 μg mL-1 for metronidazole. In … …American Journal of Applied Sciences, Vol. 4, Issue 2 · 28 Feb 2007 · 7,713 accessesView PDFCite