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26 results for “neuroprotective”
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Research ArticleOpen accessIn the abstractImpact of Euphorbia helioscopia Extract Administration on Diabetes Induced by Alloxan in MiceDoha Mohammad Beltagy, Amira Mohammed Beltagy, Mohammad Ramadan et al.Diabetes describes metabolic disorder with hyperglycemia and neurotic changes. This work aimed to evaluate the protective effect of total ethanolic extract of Euphorbia helioscopia grown in Egypt against pancreas and brain injuries in diabetic mice induced by alloxan. This work was carried out on 60 mice divided into four groups. Control Group (G1) included healthy normal mice that did not … …OnLine Journal of Biological Sciences, Vol. 20, Issue 3 · 19 Oct 2020 · 6,406 accessesView PDFCite
Research ArticleOpen accessIn the abstractAnticonvulsant Activity of Hydroalcoholic Phoenix dactylifera Fruit Extract and Pimpinella anisum Oil in MiceSameh Mohamed Mostafa EL-Nabtity, Ahmed Shaban Abdelaziz, Manar Salah Moselhi, Mario GiorgiEpilepsy is a group of long-term neurological disorders characterized by epileptic seizures. The present study sought to investigate the anticonvulsant and neuroprotective Activity of Hydroalcoholic Phoenix dactylifera fruit extract (HAPD) and Pimpinella Anisum Oil (PAO) against Pentylenetetrazole (PTZ) and Maximal Electric Shock (MES) induced a seizure in mice. Mice groups were treated with HAPD1000 mg/kg, PAO 4 ml/kg. The onset … …American Journal of Animal and Veterinary Sciences, Vol. 14, Issue 2 · 25 May 2019 · 7,590 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffect of Curcumin and Physical Training on the Brain and Motor Performance of Rats with Cerebral IschemiaKarine Sthéfany Serpa Amaral Dias, Jonas Augusto Ramos, Bruno Mattiello Gomes et al.Brain ischemia is the second most deadly disease in the world and it has already been proven that mild and moderate physical exercises minimize the deleterious effects of this disease on the brain. Curcumin has also been considered a neuroprotective substance. Therefore, the goal of this study was to evaluate the effects of high-resistance training and curcumin on the brain … …Neuroscience International, Vol. 10, Issue 1 · 25 Apr 2019 · 7,765 accessesView PDFCite
Research ArticleOpen accessIn the abstractCarica papaya Fruit Attenuates Apoptotic Degeneration After Permanent Cerebral Ischemia RatPratchaya KaewkaenApoptotic neurodegeneration is a phenomenon following cerebral ischemia. Both the increased caspase-3 and decreased Bcl-2 expression are reported to play crucial role on apoptosis in neuron. In addition, phytonutrient can successfully increase the endogenous antioxidant and lower the apoptotic responses. Therefore, anti-apoptotic effect of Carica papaya fruits was examined. To the best of our knowledge, no scientific effect was available. … …American Journal of Biochemistry and Biotechnology, Vol. 14, Issue 4 · 22 Nov 2018 · 9,790 accessesView PDFCite
Research ArticleOpen accessIn the abstractGreen Tea Treatment Attenuates Oxidative Damage and Neuromotor Deficit Induced by an Experimental Model of Intracerebral Hemorrhage in RatsMauren Assis Souza, Caroline Dalla Colletta Altermann, Alexandre dos Santos Martins et al.The present study shows the neuroprotective effect of green tea supplementation (GT; Camellia sinensis) in a model of Intracerebral Hemorrhage (ICH) in rats. ICH was induced by intra-striatum collagenase infusion in male Wistar rats. GT (400 mg Kg-1) was administered via gavage for 10 days after ICH. We assessed the effect of GT on neuromotor recovery and oxidative damage. Our … …Neuroscience International, Vol. 7, Issue 2 · 19 Mar 2017 · 8,598 accessesView PDFCite
Research ArticleOpen accessIn the abstractDouble Application of Translocator Protein Ligands and RAW Cells Inflammatory MilieuMaria Staykova, Filomena Mattner, David Linares, Andrew KatsifisLigands targeting the translocator protein exhibit a variety of anti-inflammatory and neuroprotective properties. A double application of eight translocator protein ligands to activated murine macrophage-like cells changed to a different extent the levels of secreted reactive nitrogen intermediates, pro- and anti-inflammatory cytokines. To our knowledge this is the first report suggesting that multiple applications of different translocator protein ligands may … …American Journal of Immunology, Vol. 12, Issue 3 · 28 Aug 2016 · 6,942 accessesView PDFCite
Research ArticleOpen accessIn the abstractCHRONIC NEONATAL DIAZOXIDE THERAPY IS NOT ASSOCIATED WITH ADVERSE EFFECTSMichele M. Cox, Christopher C. Wendler, Ildiko Erdelyi et al.Diazoxide is an ATP-sensitive potassium channel (KATP) agonist that has been shown to neuroprotective effects. These observations raise the possibility that diazoxide may have potential as a therapeutic agent for other applications. This study investigated (1) the long term effects of chronic neonatal administration of diazoxide and (2) the role of KATP on murin behavior and neurohistology. C57B/6J pups were … …OnLine Journal of Biological Sciences, Vol. 14, Issue 1 · 27 Jan 2014 · 7,447 accessesView PDFCite
Research ArticleOpen accessIn the abstractMulberry Fruits Extract Mitigate Vascular DementiaPratchaya Kaewkaen, Jintanaporn Wattanathorn, Terdthai Thong-Un et al.To date, Vascular Dementia (VaD) is the second most commonly found dementia following Alzheimer�s disease. Though VaD is still increasing its importance, the therapeutic efficacy is still not in satisfaction level. Therefore, the searching for an acceptable cheap and safe neuroprotective agent is in a great demand. Based on the neuroprotective and cognitive enhancing effects in alcohol neurotoxicity of mulberry … …American Journal of Applied Sciences, Vol. 9, Issue 11 · 1 Sep 2012 · 6,967 accessesView PDFCite
Research ArticleOpen accessIn the abstractSilkworm Pupae Protect Against Alzheimer’s DiseaseJintanaporn Wattanathorn, Supaporn Muchimapura, Artit Boosel et al.Silkworm (Bombyx mori) pupae have long been used as food and medicine in Asian countries. It is reputed for the treatment of numerous neurological disorders related to oxidative stress including stroke. Therefore, we hypothesized that silkworm pupae could attenuate memory impairment and neurodegeneration in Alzheimer’s disease. In the present study, we determined the effect of silkworm pupae on the neurodegeneration … …American Journal of Agricultural and Biological Sciences, Vol. 7, Issue 3 · 16 Aug 2012 · 9,697 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffects of Mulberry Fruit Powder in Animal Model of StrokePratchaya Kaewkaen, Terdthai Tong-Un, Jintanaporn Wattanathorn et al.Stroke is the leading cause of death and the important cause of disability worldwide. Presently, the effectiveness of therapeutic strategy is still very limited. Based on the role neuroprotective effect of substance possessing antioxidant effect previously reported, we hypothesized mulberry fruit a substance possessing anti-oxidant activity, might be able to protect against cognitive impairment induced by stroke or cerebral ischemia. … …American Journal of Agricultural and Biological Sciences, Vol. 7, Issue 3 · 15 Aug 2012 · 9,039 accessesView PDFCite