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87 articles for “molecular studies”
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Research ArticleOpen accessIn the abstractMolecular Characterization and in Silico Analysis of Phytochemical Compounds from Plants with Immunomodulatory PotentialHermin Pancasakti Kusumaningrum, Rejeki Siti Ferniah, Siti Nur Jannah et al.The immune system works to protect the body against foreign antigens from microorganisms and abnormal cells. The use of herbal plants as immunomodulators are used to prevent disease attacks. TNFα and interleukin-6 are pro-inflammatory immune systems that cause disease in uncontrolled synthesis. Herbal plants as inhibitors of TNFα and interleukin-6 need to be identified molecularly to reduce the occurrence of … …OnLine Journal of Biological Sciences, Vol. 25, Issue 3 · 27 Nov 2025 · 1,954 accessesView PDFCite
Literature ReviewOpen accessIn the abstractA Systematic Review of the Prevalence of Avian Hepatitis E Virus in Bird’s Husbandry Worldwide, 2000-2023 Prevalence of Avian Hepatitis E VirusJorge Eduardo Forero Duarte, Leonardo Alzate Mejía, Jaiberth Antonio Cardona-AriasAvian Hepatitis E virus (aHEV) constitutes a serious animal health problem and involves significant losses in poultry production; however, epidemiological evidence is scattered. Analyze the prevalence of aHEV infection in bird husbandry and its histopathological and phylogenetic characteristics based on scientific publications worldwide from 2000- 2023.Systematic review applying the Johanna Briggs Institute guidelines and the PRISMA guide. Exhaustiveness, reproducibility, and … …American Journal of Animal and Veterinary Sciences, Vol. 19, Issue 4 · 27 Nov 2024 · 4,150 accessesView PDFCite
Research ArticleOpen accessIn the abstractInvestigation of the Contribution of Late Embryogenesis Abundant (LEA) K Peptide in Enhancing the Expression of Lipase from Sphingobacterium sp.: In vitro and in Silico StudiesIbrahim Muhammad et al.Sphingobacterium sp. AB3 lipase is a psychrophilic enzyme with optimal lipolytic activity at pH 7 and 15°C. The cold-adapted properties of the lipase render it suitable for various low-temperature industrial applications such as biodiesel production, detergent formulation, and non-thermal food processing. Recent studies have shown that co-expression of LEA K peptide with AB3 lipase resulted in enhanced protein expression in … …American Journal of Biochemistry and Biotechnology, Vol. 20, Issue 4 · 21 Nov 2024 · 4,569 accessesView PDFCite
Research ArticleOpen accessIn the abstractPrevalence of Feline Leukemia Virus and Feline Immunodeficiency Virus in Patients from Veterinary Centers in Three Colombian CitiesAna Sofía Mejía-Villada, Maria José Arenas-González, Carolina Ríos Usuga et al.In Colombia, research on Feline Leukemia Virus (FeLV) and Feline Immunodeficiency Virus (FIV) is incipient, despite being the viruses of greatest clinical and epidemiological importance in domestic cats, presenting a worldwide distribution but with very variable prevalence. To determine the molecular prevalence of FeLV and FIV and their associated factors in domestic cats treated in veterinary centers in three Colombian … …American Journal of Animal and Veterinary Sciences, Vol. 19, Issue 3 · 11 Jun 2024 · 7,283 accessesView PDFCite
Literature ReviewOpen accessIn the abstractSystematic Review of Single Nucleotide Polymorphisms of Cattle Beta-Lactoglobulin Gene and their Association with Milk Production TraitsThlarihani Cynthia Makamu, Thobela Louis TyasiThe application of molecular genetics technology to pinpoint certain DNA markers associated with commercially significant features is highly anticipated since it has the potential to enhance the effectiveness of breeding programs by selecting young animals early for use as future breeding stock. One of the main genes expressed in bovine milk is the Beta-Lactoglobulin Gene (βLG), and its polymorphism can … …American Journal of Animal and Veterinary Sciences, Vol. 19, Issue 2 · 4 Mar 2024 · 5,811 accessesView PDFCite
Research ArticleOpen accessIn the abstractMechanism Analysis of Artemisinin and Artesunate as Lung Cancer Therapy Agents Through in Silico MethodDidik Harmoko, Vivitri Dewi Prasasty, Adi YulandiSeveral in vitro studies have focused on the ability of artemisinin and its derivatives to suppress lung cancer cells, but there are still many biological processes and mechanisms, such as the interactions between the active compounds (ligands) and receptors that are not well understood and require further research. Drug targeting for lung cancer will be more precise and the inhibition … …OnLine Journal of Biological Sciences, Vol. 24, Issue 3 · 15 Feb 2024 · 6,144 accessesView PDFCite
Research ArticleOpen accessIn the abstractPotency of Pepsin Soluble Collagen from Indonesian Local Goat Skin as an AntioxidantRina Wahyuningsih, Rusman, Nurliyani et al.Pepsin Soluble Collagen (PSC) hydrolyses is derived from the collagen extraction process from Indonesia local goat skin (Kacang) was carried out in some previous studies. This study is considering the first research used the collagen from the goat skin as an antioxidant compound. The main purpose of study were to investigate antioxidant activity of PSC hydrolysis after pepsin treatment. The … …American Journal of Animal and Veterinary Sciences, Vol. 16, Issue 3 · 22 Aug 2021 · 7,516 accessesView PDFCite
Research ArticleOpen accessIn the abstractKRLSMDA: Identifying Human miRNA–Disease Association Based on Similarity and Kronecker Regularized Least Squares MethodLingzhi Zhu, Weimin Gao, Guixiang Li et al.A growing number of studies have suggested that miRNAs (microRNAs) have associations with human diseases, the design and discovery of drug. But so far, we do not yet fully understand the molecular mechanism of miRNAs in the development of human diseases. Predicting miRNA-disease associations is helpful for understanding the molecular mechanism of miRNAs in the development of human diseases. However, … …American Journal of Biochemistry and Biotechnology, Vol. 17, Issue 1 · 15 Mar 2021 · 6,403 accessesView PDFCite
Research ArticleOpen accessIn the abstractComputer Aid Screening for Potential Antimalarial Choroquinone Compounds as Covid 19 Utilizing Computational Calculations and Molecular Docking StudyAsmaa Aboelnaga, Asmaa M. Fahim, Taghreed H. EL-SayedClick reaction of 4,7-dichloroquinoline (1) with thiosemicarbazide (2) to afford the corresponding 2-(7-chloroquinolin-4-yl)thiosemicarbazide (3) utilized ultrasonic irradiation which can cyclized easily with ethylacetoacetate to give the 3-(7-chloroquinolin-4-ylamino)-tetrahydro-6-methyl-2-thioxopyrimidin-4(1H)-one (4) via nucleophilic substitution reaction. The synthesized compounds was examined in vitro antimalarial activity with IC50 = 11.92, 25.37 μg/mL against chloroquinone drug. Furthermore, the theoretical investigation of most active compounds CQT and … …OnLine Journal of Biological Sciences, Vol. 20, Issue 4 · 30 Nov 2020 · 6,568 accessesView PDFCite
Research ArticleOpen accessIn the abstractAn Effective and Viable DNA Extraction Protocol for FFPE Tissues and its Effect on Downstream Molecular ApplicationSai Sushmitha Kontham, Charles Emmanuel Jebaraj Walter, Manjula Raju et al.Archival Formalin-Fixed Paraffin-Embedded (FFPE) tissues are a readily available source of DNA for retrospective studies including genetic predisposition. FFPE tissues present significant challenges for extraction of pure genomic DNA in adequate amounts due to the harsh fixation conditions and long-term storage associated with samples. The aim of the study is to propose a simple, in-expensive, viable protocol for the extraction … …American Journal of Biochemistry and Biotechnology, Vol. 16, Issue 1 · 24 Mar 2020 · 7,374 accessesView PDFCite