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18 results for “modeling compound”
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Research ArticleOpen accessIn the abstractDeveloping a Computer Program for the Methods of Radius-Estimating Techniques for Horizontal CurvesAsma Th. Ibraheem, Fatin JananProblem statement: This study discusses the development of computer software of two phases. First phase contains the calculations of all curve elements of the four types of the horizontal curve and second phase contains the modeling of the ten methods of estimating the radius of the horizontal curve. Approach: The program is named as HCRET, which stands for Horizontal Curves … …American Journal of Engineering and Applied Sciences, Vol. 4, Issue 2 · 13 Jul 2011 · 8,028 accessesView PDFCite
Research ArticleOpen accessIn the abstractApproximation of Aggregate Losses Using SimulationMohamed Amraja Mohamed, Ahmad Mahir Razali, Noriszura IsmailProblem statement: The modeling of aggregate losses is one of the main objectives in actuarial theory and practice, especially in the process of making important business decisions regarding various aspects of insurance contracts. The aggregate losses over a fixed time period is often modeled by mixing the distributions of loss frequency and severity, whereby the distribution resulted from this approach … …Journal of Mathematics and Statistics, Vol. 6, Issue 3 · 30 Sep 2010 · 7,666 accessesView PDFCite
Research ArticleOpen accessIn the abstractNegative Binomial-Lindley Distribution and Its ApplicationHossein Zamani, Noriszura IsmailProblem statement: The modeling of claims count is one of the most important topics in actuarial theory and practice. Many attempts were implemented in expanding the classes of mixed and compound distributions, especially in the distribution of exponential family, resulting in a better fit on count data. In some cases, it is proven that mixed distributions, in particular mixed Poisson … …Journal of Mathematics and Statistics, Vol. 6, Issue 1 · 31 Mar 2010 · 15,678 accessesView PDFCite
Research ArticleOpen accessIn the abstractHydrophobic, Polar and Hydrogen Bonding Based Drug-Receptor Interaction of TetrahydroimidazobenzodiazepinonesV.K. Sahu, A.K.R. Khan, R.K. Singh, P.P. SinghAnti-HIV drug discovery has been increasingly focusing on HIV-1-RT (reverse transcriptase) as a potential therapeutic target. Tetrahydroimidazobenzodiazepinone (TIBO) belongs to non-nucleoside group of reverse transcriptase inhibitors (NNRTIs). A computational chemistry study has been performed on a series of tetrahydroimidazo-benzodiazepinones as HIV-1-NNRT inhibitors. Problem statement: In order to search out new drug of desired activity from the lead compounds, there was … …American Journal of Immunology, Vol. 4, Issue 3 · 30 Sep 2008 · 8,837 accessesView PDFCite
Research ArticleOpen accessAll words, across the recordUPLC-Q-Exactive Orbitrap-MS Analysis of Anchusa italica Retz. Flowers: Molecular Docking, Dynamics Modeling, and Pharmacokinetics for Cardiovascular DiseaseLinyang Wang, Yan Chen, Ainiwaer Aikemu, Shuge TianThis study builds on prior UPLC-Q-Exactive Orbit rap-MS analyses of Anchusa italica Retz. Flowers (Airfs) to explore their anti-cardiovascular mechanis·ms and key bioactive markers. UPLC-Q-Exactive Orbitrap-MS identified 30 major compounds, including polyphenols and flavonoids with strong antioxidant activity. The potential active ingredients were then screened using Lipinski's rule of five, and a network pharmacology method was employed to construct an … …American Journal of Biochemistry and Biotechnology, Vol. 21, Issue 2 · 25 Oct 2025 · 2,599 accessesView PDFCite
Research ArticleOpen accessAll words, across the recordMolecular Docking of New Active Compounds Towards the Acetylcholinesterase EnzymeLemaoui Tarek, Hammoudi Nour El Houda, Benguerba Yacine, Attoui AyoubMolecular docking is a key instrument in structural molecular biology and computer-assisted drug design. The objective of ligand-protein docking is to expect the main binding mode(s) of a ligand with a protein of known three-dimensional structure. Effective docking methods search high-dimensional spaces effectively and finding a scoring function that correctly ranks candidate dockings (Morris et al., 2008). In this study … …Current Research in Bioinformatics, Vol. 8, Issue 1 · 27 Feb 2020 · 11,404 accessesView PDFCite
Research ArticleOpen accessAll words, across the recordMICROWAVE-ASSISTED EXTRACTION OF PHENOLIC ANTIOXIDANTS FROM SEMIARID PLANTSJorge E. Wong-Paz, Juan C. Contreras-Esquivel, Diana Muñiz-Marquez et al.Microwave-Assisted Extraction (MAE) kinetic in three temperatures was investigated for extraction of antioxidant phenolic compounds from Jatropha dioica, Flourensia cernua, Eucalyptus camaldulensis and Turnera diffusa which are plants of semiarid regions of Mexico. The two-site kinetic model and saturation simple equation were used to describe the experimental data. The fit of the data demonstrated that saturation simple equation was better … …American Journal of Agricultural and Biological Sciences, Vol. 9, Issue 3 · 22 Mar 2014 · 7,609 accessesView PDFCite