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54 articles for “mRNA Expression”
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Research ArticleOpen accessIn the abstractHibiscus Flower Extract and Niacinamide Show Enhanced Whitening Effects in Mouse Melanoma Cells (B16F10)Jae Eun Choi, Tae Su Jang, Jung Min Park et al.Melanoma, a type of cancer that most often occurs on skin exposed to UV rays, is becoming increasingly common. Recent research has focused actively on using natural products. The goal of this study was to compare the melanin-inhibitory effects of Hibiscus (Hibiscus sabdariffa L.) flower Extract (HE) and Niacinamide (NA), a functional ingredient with whitening effects, on melanoma cells. The … …American Journal of Biochemistry and Biotechnology, Vol. 19, Issue 1 · 9 Feb 2023 · 7,226 accessesView PDFCite
Research ArticleOpen accessIn the abstractRole of the Wnt/β-Catenin Signaling Pathway in Reducing Lipogenesis of Obese Rats Under Hypoxic ExercisePeiming Xu, Zhiyuan Sun, Xiaoyi Tian et al.Hypoxic exercise exerts a significant effect on body weight loss and body fat reduction. Methods: In the present study, we constructed an obese rat model and divided rats into the following groups: Normoxic quiet (C), Hypoxic quiet (H), Normoxic Exercise (CE), and Hypoxic Exercise (HE). We employed isobaric tags for relative and absolute quantification (iTRAQ) using proteomic technology to screen … …American Journal of Biochemistry and Biotechnology, Vol. 18, Issue 2 · 3 Jun 2022 · 5,737 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffect of Cinnamomum cassia Stem-Bark Extracts on the Synthesis and Secretion of Insulin in RIN-m5F CellsAnanias Hodi Kgopa, Sebolaishi Doris Makhubela, Motetelo Alfred Mogale, Leshweni Jerry ShaiCinnamomum cassia (C. cassia) crude stem-bark extracts possess some hypoglycemic properties through inhibiting the uptake of glucose by the intestines and/or enhancing insulin sensitivity. To further investigate the mechanism through which the hypoglycemic effect is exerted, this research explored the influence of the extracts of the crude stem-bark of C. cassia, with various polarities, on particular aspects of glucose consumption … …OnLine Journal of Biological Sciences, Vol. 22, Issue 2 · 5 Apr 2022 · 5,784 accessesView PDFCite
Research ArticleOpen accessIn the abstractPunicalagin Suppresses Mediators Involved in Labor Onset and Progression in vitroCaitlyn Nguyen-Ngo, Jane C Willcox, Martha LappasSpontaneous preterm birth is the leading cause of neonatal morbidity and mortality. Inflammation plays a central role in the activation of myometrial contractions and rupture of fetal membranes associated with spontaneous preterm birth. The pomegranate polyphenol punicalagin is known to possess anti-inflammatory properties. In this study, we aimed to determine the effect of punicalagin on pro-inflammatory and pro-labor mediators in … …American Journal of Immunology, Vol. 17, Issue 1 · 22 Dec 2021 · 7,609 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffects of Vascular Endothelial Growth Factor (VEGF) on Dental Pulp Stem Cells (DPSC)Eric Mullins, Cale Forgues, Karl KingsleyDental Pulp Stem Cells (DPSCs) are non-embryonic, mesenchymal stem cells that may have significant potential for therapeutic and regenerative biomedical applications. Studies of DPSC differentiation have demonstrated the potential to form many tissue types, including neural, osteogenic and vascular precursors using cytokines and growth factors, such as Vascular Endothelial Growth Factor (VEGF). Eight previously isolated Dental Pulp Stem Cell (DPSC) … …Current Research in Medicine, Vol. 9, Issue 1 · 1 Jun 2019 · 13,831 accessesView PDFCite
Research ArticleOpen accessIn the abstractSex Dimorphism in the Fgf21 Gene Expression in Liver and Adipose Tissues is Dependent on the Metabolic ConditionNadezhda Bazhan, Tatiana Jakovleva, Natalia Balyibina et al.Fibroblast growth factor-21 (FGF21) beneficially affects carbohydrate and lipid metabolism. Previously, a sex-specific activation of Fgf21 expression was observed in humans and animals with metabolic diseases. It is unknown whether the sex differences in the Fgf21 expression are manifested in response to the natural physiological situations of fasting and refeeding. The aim of this work was to determine liver, White … …OnLine Journal of Biological Sciences, Vol. 19, Issue 1 · 29 Jan 2019 · 8,153 accessesView PDFCite
Research ArticleOpen accessIn the abstractQuercetin Promotes the Expression of Genes Involved in Phagocytosis in Bovine NeutrophilsSuphakit Srikok, Sukij Nambut, Kanruethai Wongsawan, Phongsakorn ChuammitriThis study was conducted to explore the effect of Quercetin (QH) on phagocytosis of bovine neutrophils. Neutrophils were isolated from fifteen multiparous Holstein cows. We in vitro treated neutrophils with PBS or 50 µM of Quercetin (QH) or Cytochalasin B (CytB), as phagocytosis inhibitor, prior to monitoring phagocytosis of Escherichia coli by flow cytometry and microscopic examination. Additionally, the expressions … …American Journal of Animal and Veterinary Sciences, Vol. 12, Issue 2 · 2 Aug 2017 · 8,120 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Silencing of Septin 1 via Synthetic siRNAs in Schizosaccharomyces pombeSemih Ekimler, Merve Yilmazer, Ercan AricanSeptins are evolutionary conserved GTP-binding proteins and form heterooligomers in cells to interact with cytoskeleton. The main roles of septins in cell are cytokines, membrane interactions, vesicle trafficking and microtubule and actin organization. Non-coding RNAs are key players of gene expression regulation. Small-interfering RNAs (siRNAs) belong to non-coding RNAs, are characterized by sequence complementarity to their target mRNAs. siRNAs silence … …OnLine Journal of Biological Sciences, Vol. 17, Issue 1 · 31 Mar 2017 · 7,237 accessesView PDFCite
Research ArticleOpen accessIn the abstractIdentification and Characterization of Diacylglycerol Acyltransferase in Oleaginous Yeast Rhodosporidium toruloidesZhen Wang, Huaiyuan Zhang, Lina Zhao, Yuanda SongDiacylglycerol acyltransferase (DGAT), which catalyzes TAG formation from DAG and acyl-CoA, has been considered to play a vital role in TAG accumulation in oleaginous microorganisms. The genome of oleaginous yeast Rhodosporidium toruloides contains two putative DGAT genes, RtDGATa and RtDGATb, which shared little conserved amino acid coding sequence with each other. Phylogeny tree analysis showed that RtDGATa belonged to DGAT1 … …American Journal of Biochemistry and Biotechnology, Vol. 12, Issue 4 · 17 Oct 2016 · 7,387 accessesView PDFCite
Research ArticleOpen accessIn the abstractPotential of HMEC-1 Line and HUVEC Primary Culture Cells to Study the Neonatal IgG Fc Receptor in vitroLuz Belinda Ortiz-Alegría, Irma Cañedo-Solares, Felipe Vadillo-Ortega et al.The neonatal IgG Fc receptor (FcRn) plays an important role in IgG homeostasis and immunity passive transfer. Fine points regarding these mechanisms, however, are still emerging. In order to obtain information about these phenomena, it is essential to have in vitro models of endothelium that express this receptor. In this study we chose two widely used models of human endothelial … …American Journal of Immunology, Vol. 12, Issue 1 · 21 Mar 2016 · 9,446 accessesView PDFCite