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41 results for “liver enzyme”
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Research ArticleOpen accessIn the abstractEXERCISE TRAINING REVERSES THE DELETERIOUS EFFECT OF SUCROSE INTAKE ON INSULIN RESISTANCE AND VISCERAL FAT MASS DEPOSITION ON MICEJulio Cesar Mendes Soares, Vanderlei Folmer, Gustavo Puntel, João B.T. Da RochaAbnormal fat deposition has been identified as an important mechanism of obesity-associated with insulin resistance. Literature data also indicate that exercise can improve insulin action. The heme pathway enzyme δ-Aminolevulinate Dehydratase (δ-ALA-D) is a good marker for oxidative stress and this sulfhydryl enzyme is inhibited in such oxidative pathologies diabetes. The aim of this study was to evaluate the effects … …American Journal of Biochemistry and Biotechnology, Vol. 10, Issue 1 · 28 Mar 2014 · 7,324 accessesView PDFCite
Research ArticleOpen accessIn the abstractABSENCE OF VISIBLE TOXIC EFFECTS ACCOMPANYING THE SHORT-TERM ADMINISTRATION OF AN AQUEOUS EXTRACT OF ALLIUM SATIVA LINN. IN MALE SPRAGUE-DAWLEY RATSJ. Asiedu-Gyekye Isaac, Awortwe Charles, A. Antwi DanielAllium sativum is cultivated in the northern part of Ghana and has gained widespread use as chemoprotective, in curing hypertension, impotence and erectile dysfunction. The multipurpose use together with its aphrodisiac activity has resulted in the widespread use of this plant medicine both in meals and as herbal medications. Safety assessment of this plant however is rare. The present study … …American Journal of Pharmacology and Toxicology, Vol. 9, Issue 1 · 30 Jan 2014 · 7,578 accessesView PDFCite
Research ArticleOpen accessIn the abstractHEPATOTOXIC EFFECT OF ITRACONAZOLE IN EXPERIMENTAL RATSMohammed El-Hassan Abdelmaged KemeirItraconazole is a widely used antifungal drug. In situations such as managing patients with gastrointestinal basidiobolomycosis, third of which cases world-wide occur in the southwestern region of Saudi Arabia, prolonged treatment with this drug is required. Thus, this is study was designed to investigate the hepatotoxicity of long term administration of itraconazolein in Wistar rats. Two groups of rats were … …American Journal of Animal and Veterinary Sciences, Vol. 9, Issue 1 · 30 Jan 2014 · 9,049 accessesView PDFCite
Research ArticleOpen accessIn the abstractAPIGENIN CAUSES BIOCHEMICAL MODULATION, GLUT4 AND CD38 ALTERATIONS TO IMPROVE DIABETES AND TO PROTECT DAMAGES OF SOME VITAL ORGANS IN EXPERIMENTAL DIABETESChowdhury Mobaswar Hossain, Miltu Kumar Ghosh, Bhabani Sankar Satapathy et al.Diabetes mellitus gradually leads to dysfunction and failure of some vital organs specially the eyes, kidneys, pancreas, brain, heart, liver and lungs. The study was aimed to evaluate the antidiabetic potential of apigenin and its mechanistic role in controlling damages of vital tissues in streptozotocin-induced diabetic rats. Streptozotocin-induced diabetic rats were treated with apigenin and glipizide. Various biochemical changes, GLUT4 … …American Journal of Pharmacology and Toxicology, Vol. 9, Issue 1 · 13 Jan 2014 · 15,680 accessesView PDFCite
Research ArticleOpen accessIn the abstractHYPOGLYCEMIC, HEPATO-RENAL AND ANTIOXIDANT POTENTIAL EFFECTS OF CHAMOMILE RECUTITA FLOWERS ETHANOLIC EXTRACT IN STREPTOZOTOCIN-DIABETIC RATSHassan Al-Musa, Fahaid AL-HashemThis study was undertaken to evaluate the hypoglycemic and hepatorenal protective effect of ethanolic extract of Chamomile recutita flowers in streptozotocin-Diabetic Rats. Before the beginning of the experiments, acute and subacute studies were carried out in control animals first to investigate the LD50 of this extract. In the experimental design, adult male albino rats were divided into five groups: (1) … …American Journal of Pharmacology and Toxicology, Vol. 9, Issue 1 · 9 Dec 2013 · 8,156 accessesView PDFCite
Research ArticleOpen accessIn the abstractConstitutive Androstane Receptor Dependent and Independent Modulation of CYP3A2, CYP1A2 by Phenobarbital and Fibrate in Rats’ LiverMohamed Mohamed Ahmed, Mustafa Shukry, Zein Shaban Ibrahim et al.Cytochrome P450 enzymes, CYP3A and CYP1A are major drug metabolizing enzymes in the liver. CYP3A enzymes have a major role in the metabolism of 30-40% of all used drugs. CYP1A2 is a key enzyme having an important role in the metabolic clearance of 5% of currently marketed drugs. CYP1A2 participates in the metabolic activation of chemical mutagens in cooked food, … …American Journal of Biochemistry and Biotechnology, Vol. 9, Issue 3 · 21 Sep 2013 · 7,384 accessesView PDFCite
Research ArticleOpen accessIn the abstractAqueous Stem Bark Extract of Spathodea campanulata (P. Beauv) Modulates Carbon Tetrachloride Induced Hepatic Damage in RatsCharles Ansah, Phyllis Elsie Dadzeasah, Emmanuel AsiamahThe objective of the present study was to evaluate the hepatoprotective and curative potential of the aqueous extract of the stem bark of Spathodea Campanulata (SCE) in a carbon tetrachloride-induced model of hepatotoxicity in rats. Rats pre-treated with 625 mg kg-1, 1250, 2500 mg kg-1 or silymarin (50 mg kg-1) p.o for 3 days were intoxicated with CCl4 (1 mL … …American Journal of Pharmacology and Toxicology, Vol. 8, Issue 1 · 27 May 2013 · 9,003 accessesView PDFCite
Research ArticleOpen accessIn the abstractProtection of Terminalia belerica Roxb. Against Iron Overload Induced Liver Toxicity: An Account of Its Reducing and Iron Chelating CapacityBibhabasu Hazra, Rhitajit Sarkar, Nripendranath MandalExcess iron deposition in the liver catalyses the production of Reactive Oxygen Species (ROS) which in turn initiate oxidative damage of protein and nucleic acids leading to several human diseases. The fruits of Terminalia Belerica Roxb. (TB) has been most commonly used not only in stimulating gastrointestinal health, but also in treatment of various hepatic disorders. The present study was … …American Journal of Pharmacology and Toxicology, Vol. 7, Issue 3 · 20 Nov 2012 · 7,993 accessesView PDFCite
Research ArticleOpen accessIn the abstractStudies on the Seasonal Changes in Antioxidant Enzymes Activity on Differently, Polluted Areas along the Bay of Bengal Employing Perna viridis as an Animal ModelC. Amutha, P. SubramanianAntioxidants are the innate or acquired molecules capable of slowing down or preventing the oxidative damage (damage due to reactive oxygen species) that caused by free radicals. The antioxidant enzyme activity in response to season as well as hydrocarbon pollution was attempted. Rayapuram fishing harbor of Chennai (Station-1) is highly oil contaminated with oil sleeks on the surface. The relatively … …American Journal of Animal and Veterinary Sciences, Vol. 7, Issue 2 · 31 Jul 2012 · 7,670 accessesView PDFCite
Research ArticleOpen accessIn the abstractLipid Profile and Antioxidant Enzymes in Normal and Stressed Rat Fed with Palm OleinEqbal M.A. Dauqan, Aminah Abdullah, Halimah Abdullah SaniProblem statement: The objective of the study was to evaluate the effect of Red Palm Olein (RPO) and Palm Olein (PO) on lipid profile and antioxidant enzyme in normal and stressed rat. Approach: Thirty six Sprague Dawley male rats which were randomly divided into six groups of 6 rats per group (tree normal groups and three stressed groups) were treated … …American Journal of Applied Sciences, Vol. 9, Issue 7 · 18 May 2012 · 6,882 accessesView PDFCite