16 results for “immunosuppression”

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Research ArticleOpen accessIn the abstractUnderstand the Role of Natural KillerHan Yuen Lam, Swee Keong Yeap, Noorjahan Banu Alitheen et al.Problem statement: Immunosuppression is a common approach for pathogens or cancer to escape from immune system of the infected host. Some of the antimicrobe or anticancer drugs may also weaken the body immune system. Among various types of immune cell, natural killer cells are the key component of the innate immunity which plays an important role in first line defense … …American Journal of Immunology, Vol. 6, Issue 4 · 5 Aug 2011 · 7,935 accessesView PDF Cite

Research ArticleOpen accessIn the abstractA Case of Refractory Salmonella Spondylodiscitis in an Immunocompetent Patient Treated Via an Extracavitary Approach, Corpectomy and Placement of Expandable CageKimon Bekelis, Oren Gottfried, Zyia L. Gokaslan et al.Problem statement: Salmonella spondylodiscitis is a rare condition that is more prevalent in patients with sickle cell disease or immunosuppression. However, it can also be found in immunocompetent patients. It usually responds well to proper antibiotics. However, surgery is rarely indicated when the infection is refractory to antibiotics, the spine is destabilized or there is an epidural component that is … …American Journal of Infectious Diseases, Vol. 6, Issue 2 · 30 Jun 2010 · 7,533 accessesView PDF Cite

Research ArticleOpen accessIn the abstractCytokines as Adjuvants for Vaccine and Cellular Therapies for CancerChristian M. Capitini, Terry J. Fry, Crystal L. MackallProblem statement: The development of a potent vaccine that can help treat tumors resistant to conventional cytotoxic therapies remains elusive. While part of the problem may be that trials have focused on patients with bulky residual disease, the desire to maximize responses to the vaccine remains. Approach: The gamma (γ) family of cytokines offered a unique opportunity to support the … …American Journal of Immunology, Vol. 5, Issue 3 · 30 Sep 2009 · 14,348 accessesView PDF Cite

Research ArticleOpen accessIn the abstractThe Role of Treg Cells in the Cancer Immunological ResponseZhi-Zhang Yang, Stephen M. AnsellProblem statement: T cell-mediated immunosuppression has been observed for decades without clarification as to which factor was responsible for this observation. The identification of CD4+CD25+ regulatory T (Treg) cells represents a milestone in the filed of immunology and provides an explanation for T-cell-mediated immunosuppression. Although Treg cells were originally identified for their ability to prevent organ-specific autoimmune disease in mice, … …American Journal of Immunology, Vol. 5, Issue 1 · 31 Mar 2009 · 8,518 accessesView PDF Cite

Research ArticleOpen accessIn the abstractSecretary IgA Concentrations and plasma Cell Count Changes Associated with the Estrous Cycle in EwesMorteta H. AL-Medhtiy, A. B.Z. Zuki, M. M. Noordin, S. AgungpriyonoProblems statement: The level of uterine Secretory-IgA (S-IgA) and numbers of plasma cells was measured to observe the differences between two stages of estrous cycle (follicular and luteal phase) in the healthy cycling non pregnant ewes. Approach: Twelve ewes were used in this study and they were divided into two groups of 6 animals each according to the stages of … …American Journal of Animal and Veterinary Sciences, Vol. 4, Issue 1 · 31 Mar 2009 · 8,189 accessesView PDF Cite

Research ArticleOpen accessIn the abstractSelective Lymphocyte Activation and Inhibition of In Vitro Tumor Cell Growth by Novel MorphinansRicardo Gomez-Flores, Kimberly R. Vietti, William J. Dunn et al.Opioids can suppress immune functions and increase susceptibility to developing cancer and infectious diseases. Recently, novel opioid compounds have been synthesized that lack immunosuppressive effects. We evaluated the effects of morphinans with substituted pyrimidine (methyl, phenyl, hydroxy, and amino groups) and pyrazole groups on in vitro rat thymic lymphocyte and splenic macrophage functions, and tumor cell growth. We observed that … …American Journal of Immunology, Vol. 2, Issue 1 · 5 Mar 2005 · 7,078 accessesView PDF Cite