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21 results for “immunohistochemistry”
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Research ArticleOpen accessIn the abstractIntravenous Injection of Umbilical Cord-Derived Mesenchymal Stem Cells Improved Regeneration of Rat Liver after 2AAF/CCl4-Induced InjuryIsabella Kurnia Liem, Reni Oktavina, Zakiyah et al.The effectivity of Mesenchymal Stem Cell (MSC) therapy for chronic liver injury is still questioned due to its possibility to have a pro-fibrotic effects. Other consideration is the preferably peripheral Intravenous (IV) route of application rather than direct to the target organ, such as portal vein or splenic vein, since the most of MSC will be trapped in the lung … …OnLine Journal of Biological Sciences, Vol. 21, Issue 2 · 10 Jun 2021 · 6,780 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Dynamic of Afamin and Alpha-Fetoprotein Expression during Rat Liver DevelopmentIndriyani, Isabella Kurnia Liem, Puspita Eka Wuyung et al.Liver has a high level of Alpha-fetoprotein which is assumed to be important for mammalian development. However, Alpha-fetoprotein knockout studies in mice suggested that despite the absence of Alpha-fetoprotein, mice developed normally; the only abnormality observed was infertility in female mice. There are indications that Afamin, a protein that has a gene sequence located on the same chromosome as Alpha-fetoprotein, … …OnLine Journal of Biological Sciences, Vol. 21, Issue 1 · 5 Feb 2021 · 6,766 accessesView PDFCite
Research ArticleOpen accessIn the abstractModeling Hepatocellular Toxicity of Enavatuzumab, a Humanized Anti-TweakR AntibodyDonghee Choi, Yanhong Zhu, Debra Tien Chao et al.In a Phase 1 clinical study, treatment with enavatuzumab, a humanized monoclonal antibody to TweakR, resulted in liver toxicity in a subset of patients. The objective of this current study was to evaluate the ability of preclinical studies to predict liver toxicity in humans. Enavatuzumab was evaluated in cynomolgus monkeys, where serum liver enzyme and cytokine levels were measured and … …American Journal of Pharmacology and Toxicology, Vol. 12, Issue 2 · 9 Nov 2017 · 7,719 accessesView PDFCite
Research ArticleOpen accessIn the abstractTAURINE ATTENUATES HEPATIC AND CARDIAC DAMAGE AND APOPTOSIS IN RABBITS FED A HIGH-FAT DIETGamal Hasan Abdel-RahmanA hypercholesterolemia diet has been associated with the hepatic and cardiac abnormalities and the pathological changes. The present work was designed to investigate the histological and immunohistochemical changes in the liver and heart of rabbits when fed high fat diet and the possible protective role of an antioxidant "taurine". Twenty-four male white New Zealand rabbits were divided into four groups, … …OnLine Journal of Biological Sciences, Vol. 14, Issue 1 · 28 Dec 2013 · 6,931 accessesView PDFCite
Research ArticleOpen accessIn the abstractSpatial Distribution of Fibroblast Growth Factor Receptor 2 in Normal and Lesioned Central Nervous System of Pleurodeles waltliiMarie Moftah, Marc Landry, Frederic Nagy, Jean-Marie CabelguenFibroblast Growth Factors (FGFs) have been implicated in numerous cellular processes including proliferation, migration, differentiation and neuronal survival. One of these growth factors, Fibroblast Growth Factor 2 (FGF2), is apparently implicated in the ability of the adult salamander (Pleurodeles waltlii) to recover locomotion following complete transection of the spinal cord. In a previous study, we reported up regulation of FGF2 … …Neuroscience International, Vol. 3, Issue 2 · 4 Sep 2012 · 7,145 accessesView PDFCite
Research ArticleOpen accessIn the abstractDiphenylhydantoin Promotes Proliferation in The Subventricular Zone and Dentate GyrusAlma Y. Galvez-Contreras, Rocio E. Gonzalez-Castaneda, Sonia Luquin et al.Problem statement: Diphenylhydantoin (phenytoin) is an antiepileptic drug that generates hyperplasia in some tissue by stimulating Epidermal Growth Factor (EGFR) and Platelet-Derived Growth Factor beta (PDGFR-β) receptors and by increasing serum levels of basic fibroblast growth factor (bFGF, FGF2 or FGF-β). Neural stem cells in the adult brain have been isolated from three regions: the Subventricular Zone (SVZ) lining the … …Neuroscience International, Vol. 3, Issue 1 · 6 Mar 2012 · 9,135 accessesView PDFCite
Research ArticleOpen accessIn the abstractPrenatal Exposure to Chronic Ethanol on N Methyl D Aspartate Receptor DistributionM. Taherianfard, B. Geramizadeh, E. Evazi, M. SharifiProblem statement: Effect of chronic exposure to ethanol on NR1 subunit of the NMDA receptor distribution in chick embryo brain chronic ethanol intake leads to the development of dependence on and tolerance to ethanol in both human and animals. The glutamate system plays a major role in mediating ethanol effects on brain and behavior. The aim of the present study … …American Journal of Pharmacology and Toxicology, Vol. 6, Issue 4 · 21 Feb 2012 · 7,301 accessesView PDFCite
Research ArticleOpen accessIn the abstractDengue during Pregnancy: A Study of Thirteen CasesChristiane Fernandes Alvarenga, Vânia Glória Silami, Patrícia Brasil et al.Problem statement: The principal aim was to evaluate the effects of dengue virus infection by dengue during pregnancy and analyze the histopathology of the placenta. Approach: A retrospective study was conducted with 13 pregnant women with dengue confirmed in the period from January-December 2002, during a widespread dengue type 3 epidemic in Rio de Janeiro. Maternal and newborn data were … …American Journal of Infectious Diseases, Vol. 5, Issue 4 · 31 Dec 2009 · 8,993 accessesView PDFCite
Research ArticleOpen accessIn the abstractConcomitant Down Regulation of Glycolytic Enzymes, Upregulation of Gluconeogenic Enzymes and Potential Hepato-Nephro-Protective Effects Following the Chronic Administration of the Hypoglycemic, Insulinotropic Citrullus colocynthis Pulp ExtractMohammad Dallak, Nabil Bashir, Mohammad Abbas et al.Background Citrullus colocynthis pulp seedless extract has been demonstrated to have antihyperglycemic and insulinotropic effects. Problem statement: The mechanism(s) underlying the antihyperglycemic and insulinotropic effects have not been investigated to date. Approach: The influence of Citrullus colocynthis pulp extract administered orally was studied in alloxan diabetic white albino rats. Rats were divided into four groups, the first group was normal … …American Journal of Biochemistry and Biotechnology, Vol. 5, Issue 4 · 31 Dec 2009 · 7,898 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Interplay between p53 and p21 Tumor Suppressor Proteins in the Transformation of Colorectal Adenoma to CarcinomaA.S. Abdulamir, R.R. Hafidh, L.K. Mahdi et al.This study was carried out for evaluating the interplay of p53, p21 and Ki-67 proteins along the colorectal adenoma-carcinoma oncogenic transformation sequel. Therefore, Fifty colorectal cancer and 14 adenoma patients were involved. The histopathological expression of p53, p21 and Ki-67 proteins was evaluated by immunohistochemistry assay. The results revealed that remarkable overexpression of p53 protein was seen in the tumorous … …American Journal of Immunology, Vol. 4, Issue 2 · 30 Jun 2008 · 7,740 accessesView PDFCite