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23 results for “hepatotoxicity”
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Research ArticleOpen accessIn the keywordsEffect of Green Tea on Hepatic Cells Under the Influence of Inflammatory Conditions: In Vitro StudyIbrahim G. Saleh, Zulfiqar Ali, Farid M. Hamada et al.The concern about safety of consumption of Green Tea (GT) supplements has become a scope of many studies. We and others have described earlier the effect of the administration of GT and its polyphenols on liver in a mouse model. In this study we aimed to investigate the effect of GT on HepG2 cells. HepG2 cells were treated with different … …American Journal of Pharmacology and Toxicology, Vol. 8, Issue 4 · 3 Dec 2013 · 7,314 accessesView PDFCite
Research ArticleOpen accessIn the keywordsToxicity evaluation of yoyo 'cleanser' bitters and fields Swedish bitters herbal preparations following sub-chronic administration in ratsMartins Ekor, Odusoga Adewale Osonuga, Adesina Olalekan Odewabi et al.Problem statement: Owing to numerous adverse effects of most orthodox pharmaceuticals, the use of herbal remedies in treatment and prevention of diseases is gaining much attention, especially in developing countries. The increase patronage of these remedies is often predicated on the assumption that they are harmless since they are prepared from natural sources. However, toxicity related to herbal medicines is … …American Journal of Pharmacology and Toxicology, Vol. 5, Issue 4 · 13 Jun 2011 · 10,198 accessesView PDFCite
Review ArticleOpen accessIn the abstractDietary Flavonols With Antiviral Efficacy: Safety and Regulatory ConcernsTanisha Parvez, Tanveer Yaqub, Shama Parveen, Mohammad Khalid ParvezGlobally, a variety of pharmacologically-active plant or natural products are commonly consumed as health-protective dietary supplements. These are marketed as crude formulations, isolated metabolites, multi-vitamins, essential amino acids, unsaturated fatty acids and minerals. Of these, pharmacologically-active flavonols like rutin, quercetin, kaempferol, myricetin, isorhamnetin are the most consumed dietary supplements. In addition to their broad-spectrum therapeutic benefits, these are also known … …American Journal of Pharmacology and Toxicology, Vol. 20, Issue 1 · 19 Apr 2026 · 1,866 accessesView PDFCite
Review ArticleOpen accessIn the abstractThe Impact of Di-2-Ethylhexyl Phthalate (DEHP) in Focus on the Reproductive System and Toxicity in Rat or Mammalian ModelVenkataramanaiah Poli, Srinivasulu Reddy MotireddyAbsalan, F., Saremy, S., Mansouri, E., Moghadam, M. T., Moghadam, A. R. E., & Razie, G. (2016). Effects of Mono-(2-Ethylhexyl) Phthalate and Di-(2-Ethylhexyl) Phthalate Administrations on Oocyte Meiotic Maturation, Apoptosis and Gene Quantification in Mouse Model. Cell Journal, 18(4), 503–513. https://doi.org/10.22074/cellj.2016.4717 Acevedo‐Rodriguez, A., Kauffman, A. S., Cherrington, B. D., Borges, C. S., Roepke, T. A., & Laconi, M. (2018). Emerging … …American Journal of Pharmacology and Toxicology, Vol. 19, Issue 1 · 6 Jun 2024 · 12,990 accessesView PDFCite
Research ArticleOpen accessIn the abstractAntiretroviral Toxicity and Oxidative StressAdikwu Elias, Brambaifa Nelson, Deo Oputiri, Oru-Bo Precious GeoffreyAntiretroviral drugs are used for the treatment of human immunodeficiency virus, they are used as combination regimens to achieve the highest possible benefit, tolerability, compliance and to diminish the risk of resistance development. Reports from preclinical and clinical studies have linked antiretrovirals with some toxicological effects which could be associated with redox imbalance (oxidative stress). This stimulated us to review … …American Journal of Pharmacology and Toxicology, Vol. 8, Issue 4 · 20 Nov 2013 · 8,255 accessesView PDFCite
Research ArticleOpen accessIn the abstractAqueous Stem Bark Extract of Spathodea campanulata (P. Beauv) Modulates Carbon Tetrachloride Induced Hepatic Damage in RatsCharles Ansah, Phyllis Elsie Dadzeasah, Emmanuel AsiamahThe objective of the present study was to evaluate the hepatoprotective and curative potential of the aqueous extract of the stem bark of Spathodea Campanulata (SCE) in a carbon tetrachloride-induced model of hepatotoxicity in rats. Rats pre-treated with 625 mg kg-1, 1250, 2500 mg kg-1 or silymarin (50 mg kg-1) p.o for 3 days were intoxicated with CCl4 (1 mL … …American Journal of Pharmacology and Toxicology, Vol. 8, Issue 1 · 27 May 2013 · 8,999 accessesView PDFCite
Research ArticleOpen accessIn the abstractHepatoprotective Effect of Vitamin EElias Adikwu, Brambaifa NelsonDrugs and some chemical agents are known to induce hepatotoxicity in humans which is of great concern to clinicians. Chemical agents are been screen daily for their hepatoprotective properties. Among these chemical agents is vitamin E which has drawn wide attention due to it reported hepatoprotective property as reported by researchers. This study collected and evaluated reports to ascertain the … …American Journal of Pharmacology and Toxicology, Vol. 7, Issue 4 · 15 Mar 2013 · 8,003 accessesView PDFCite
Research ArticleOpen accessIn the abstractHepatoprotective Effect of Taurine Against Oxidative Stress Due to Methotrexate in RatE. Issabeagloo, M. Taghizadiyeh, P. KermanizadehProblem statement: Taurine, 2-aminoethanesulphonic acid is an essential amino acid. It is present at high concentrations in many tissues. It plays important roles in numerous physiological functions including conjugation with bile acids, modulation of calcium levels and maintenance of osmolarity, antioxidation and stabilization of membranes. Methotrexate (MTX), as the most disease modifying anti-rheumatic drug used for Rheumatoid Arthritis (RA), has … …American Journal of Animal and Veterinary Sciences, Vol. 6, Issue 4 · 16 Jan 2012 · 8,495 accessesView PDFCite
Research ArticleOpen accessIn the abstractEvaluation of in vivo Antioxidant and Hepatoprotective Activity of Portulaca oleracea L. against Paracetamol-Induced Liver Toxicity in Male RatsMohamed H. AhmidaProblem statement: Oxidative stress plays a major role in paracetamol induced hepatotoxicity. Portulaca oleracea (P.O.) has been shown to exhibit antioxidant properties. The present study aimed to investigate the effect of P.O. on the oxidative stress in Paracetamol-induced hepatic toxicity in male rats. Approach: Forty male rats were divided into four groups. Group I served as control; Group II Received … …American Journal of Pharmacology and Toxicology, Vol. 5, Issue 4 · 13 Jun 2011 · 7,327 accessesView PDFCite
Research ArticleOpen accessIn the abstractAntilithiatic Influence of Spirulina on Ethylene Glycol-Induced Nephrolithiasis in Male RatsAtef M. Al-AttarProblem statement: Nephrolithiasis or renal stone disease remains a significant health problem in the adult population. Nephrolithiasis is a recurrent disorder prominent in males. It is significant medical and surgical problem because of incidence, recurrence and severe consequences. The present day medical management of nephrolithiasis is either costly or not without side effects. Invasive procedures for the treatment of nephrolithiasis … …American Journal of Biochemistry and Biotechnology, Vol. 6, Issue 1 · 31 Mar 2010 · 70,595 accessesView PDFCite