Research ArticleOpen accessIn the abstractReverse Pharmacology-A Paradigm Shift for Drug Discovery and DevelopmentAshok D.B. VaidyaThe current scenario of drug discovery and development is facing a model perturbation, despite significant advances in genomics, proteomics, metabolomics, combinatorial chemistry and high through put assays. There is an urgent need of a paradigm shift in approaches to drug discovery. Natural products of Ayurveda offer a vast potential for novel phytomolecules with clinical activity. In India, Ayurveda is availed … …Current Research in Drug Discovery, Vol. 1, Issue 2 · 26 Jan 2015 · 15,398 accessesView PDFCite
Research ArticleOpen accessIn the abstractProposal of a Genome Editing System for Genetic Resistance to Tomato Spotted Wilt VirusFederico Martinelli, Giovanni Grillone, Filippo SgroiViruses provoke considerable economical losses in agriculture. New molecular approaches to develop genetic resistance based on translational genomics and precision genetic modifications are highly expected. The type II Clustered, Regularly Interspaced Palindromic Repeats (CRISPR) system including Cas9 nuclease represent a promising and very powerful tool to specifically modulate the expression and activity of genes involved in biotic stress responses. In … …American Journal of Applied Sciences, Vol. 11, Issue 11 · 7 Jan 2015 · 7,685 accessesView PDFCite
Research ArticleOpen accessIn the abstractNutrition in Tertiary Education: Biological and Social ApproachesG. A. Fragkiadakis, C. Papandreou, K. GkouskouProblem statement: Human Nutrition, a necessary component of health-education, studies the food-depended growth/maintenance of the human body. To approach what nutritionists will need to apply in the 21st century, we searched the literature for new syllabus-fields. Approach: We detected fields likely to play a significant and innovative role in university teaching of Human Nutrition; then tried a synthesis of biological … …Journal of Social Sciences, Vol. 8, Issue 2 · 18 Feb 2012 · 8,590 accessesView PDFCite
Research ArticleOpen accessIn the abstractEntropyomics as the Blueprint of the Logic of Normal Cell Division and MalignancyKambiz AfrasiabiProblem statement: In this article I propose a blueprint based on one of the most fundamental laws governing the known universe, namely the second law of thermodynamics and I present support for its central role in initiation of mitosis and relationship of the other sub cellular compartments and their organization. Approach: Life is considered to be the most sophisticated antientropy … …OnLine Journal of Biological Sciences, Vol. 11, Issue 1 · 6 Jul 2011 · 10,377 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Widely Used Diagnostics "DNA Microarray"-A ReviewR. Manoj KumarProblem statement: DNA microarray technique is one of the latest advances in the field of molecular biology and medicine. It is a multiplex technique used in combination of bioinformatics and statistical data analysis. Since, 1995, the technique offers the possibility of conducting tens or hundreds of thousands of simultaneous hybridizations. Approach: This increased experimental efficiency permits high throughput and whole … …American Journal of Infectious Diseases, Vol. 5, Issue 3 · 30 Sep 2009 · 7,787 accessesView PDFCite