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43 articles for “gene expression data”
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Research ArticleOpen accessIn the abstractClassification of Non-Small Cell Lung Cancer Based on Gene Expression in Cases of Smokers and Non-Smokers using Ensemble Methods with Statistical Based Feature SelectionFhira Nhita, Isman KurniawanLung cancer is one of the leading causes of death globally. One of the main risk factors for lung can ceris smoking, which causes more than 90% of lung cancer cases. There are two types of lung cancer, i.e., Small Cell Lung Cancer (SCLC) and Non-Small Cell Lung Cancer (NSCLC), which the latter is the most common. One method that … …Journal of Computer Science, Vol. 18, Issue 10 · 30 Sep 2022 · 6,093 accessesView PDFCite
Research ArticleOpen accessIn the abstractNattokinase Activity Guided Natto Fermentation Process OptimizationXiaojie Ren, Chao Huang, Xin Shan et al.The natto kinase in natto has obvious thrombolytic effect, has the advantages of low cost, small side effects, long half-life and can be taken orally, so it has attracted much attention. At present, the research on natto kinase in our country mainly focuses on the selection of natto fermentation strains, the optimization of gene expression conditions and the exploration of … …American Journal of Biochemistry and Biotechnology, Vol. 17, Issue 4 · 20 Dec 2021 · 7,151 accessesView PDFCite
Research ArticleOpen accessIn the abstractComparative Effect of Ulvan and Biosynthesized Silver Nanoparticles on Different Cell Lines Cytotoxicity and Gene ExpressionHadear Hanie Amin, Mohammed Ahmed Taha AbdelreheemUntil now, researchers searching for compounds that contribute for treating the most serious disease of this age, cancer. Researchers hope to contribute to this through this research. Activities of both Ulvan extracted from Ulva lactuca and silver nanoparticles (Ag-NPs) were examined against seven different cancer cell types called (Caco2 cells, A549 cells, Mcf7 cells, Hep2 cells, HepG2 cells, PC3 cells, … …OnLine Journal of Biological Sciences, Vol. 20, Issue 2 · 30 Jun 2020 · 6,675 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Relevance of Bioinformatic Tools in the Study of Polymorphisms of the B4GALNT2 Gene and its Association with CancerEddaikra Atika, Haddouche Hayet, Touil-Boukoffa ChafiaThe human gene B4GALNT2 encodes an enzyme (β1,4-N-acetylgalactosaminyltransferase II) that controls the expression of the blood group Sda carbohydrate’s antigen. This gene is located in position 17q21,32 and consists of 11 exons. The characterization and understanding of genetic variation is a real challenge in human genetics, both for healthy individuals and diseased ones. The in silico study of the B4GALNT2 … …Current Research in Bioinformatics, Vol. 8, Issue 1 · 27 Feb 2020 · 6,767 accessesView PDFCite
Research ArticleOpen accessIn the abstractCopper (I)-Nicotinate Promotes Gene Expression of CYPs that Produce M1 and Q1 in Aflatoxicosed RatsMohammed Salah, Laila Mostafa, Tahia H. Saleem et al.Aflatoxin-contaminated food poses a serious risk to both human and animal health. Copper (1)-nicotinate (Cu+-nicotinate) complex potentiated the prophylactic effect against chronic aflatoxicosis in the experimental animals through the synthesis of less toxic metabolites M1 and Q1 which are easily excreted in urine. To investigate the action of the safety Cu+-nicotinate complex on gene expression of Cytochrome 450 (CYP450) system, … …American Journal of Biochemistry and Biotechnology, Vol. 16, Issue 1 · 28 Jan 2020 · 8,152 accessesView PDFCite
EditorialOpen accessIn the abstractEditorial Commentary: Challenge of Non–AIDS-Defining Cancers (NADCs), Focusing on Trans Activation Response Element (TAR) RNA Embedding ExosomesLechuang Chen, Ge JinGlobally, 37.9 million people were living with HIV at the end of 2018 (Organization, 2018). Cancer is a major cause of mortality and morbidity in AIDS patients and chronically HIV-infected people. With the aid of combination Antiretroviral Therapy (ART), people living with HIV (PLWH) have a longer life span. However, because the virus is not completely eradicated, PLWH under antiretroviral … …American Journal of Immunology, Vol. 15, Issue 1 · 28 Nov 2019 · 6,657 accessesView PDFCite
Research ArticleOpen accessIn the abstractComparative Functional Analysis of the Basic Helix-Loop-Helix Proteins in the Clawed Frogs' Genomes With Common Essential Pathways and Enriched Gene Ontology TermsWuyi LiuThe international Gene Ontology (GO) and pathway databases were used to functionally analyze the clawed frogs' Basic Helix-Loop-Helix (bHLH) transcription factors of Xenopus tropicalis and Xenopus laevis in a updated genome-wide survey. There were 41 GO terms and one pathway significantly enriched for Xenopus tropicalis, whereas there were 45 GO terms and 3 pathways significantly enriched for Xenopus laevis. Among … …American Journal of Biochemistry and Biotechnology, Vol. 15, Issue 1 · 28 Mar 2019 · 8,490 accessesView PDFCite
Research ArticleOpen accessIn the abstractDimensionality Reduction using Principal Component Analysis for Cancer Detection based on Microarray Data ClassificationAdiwijaya, Untari N. Wisesty, E. Lisnawati et al.Cancer is one of the most deadly diseases in the world. The International Agency for Research on Cancer (IARC) noted 14.1 million new cancer cases and 8.2 million deaths from cancer in 2012. In the last few years, DNA microarray technology has increasingly been used to analyze and diagnose cancer. Analysis of gene expression data in the form of microarray … …Journal of Computer Science, Vol. 14, Issue 11 · 15 Nov 2018 · 9,930 accessesView PDFCite
Research ArticleOpen accessIn the abstractSequence Analysis of Scaffold/Matrix Attachment Regions (S/MARs) From Human Embryonic Kidney and Chinese Hamster Ovary CellsNur Shazwani Mohd Pilus, Azrin Ahmad, Nurul Yuziana Mohd YusofBinding of intergenic Scaffold/Matrix Attachment Regions (S/MARs) to nuclear matrix proteins is believed to poise adjacent genes for transcription by forming chromatin loops. Vector constructs containing Scaffold/Matrix Attachment Regions (S/MAR) flanking the gene of interest, therefore, are able to enhance recombinant protein expression in mammalian cells. We compared two methods that are based on buffers containing 2M NaCl and Lithium-3,5-diidosalicylate … …OnLine Journal of Biological Sciences, Vol. 18, Issue 4 · 8 Oct 2018 · 7,630 accessesView PDFCite
EditorialOpen accessIn the abstractFocalize the Structure of Myd88 in TLR Signaling Pathway to Modulate Innate Immune Response: New Target for Old DiseasesShuai Xing, Ping ZhouAll diseases have their Achilles’ Heel to target and this is especially true for immunorelated diseases which must be treated by targeting the immune system somewhere and somehow correctly. In the most recent decade, immunologists recognized that the Toll-Like Receptor (TLR) signaling pathway in innate immune system plays a double-edged role in the pathogenesis of many notorious diseases. Although the … …American Journal of Immunology, Vol. 13, Issue 3 · 6 Sep 2017 · 7,862 accessesView PDFCite