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23 results for “female rats”
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Research ArticleOpen accessIn the abstractThe Influence of Garcinia kola Seed on Sexual Behavior and Testis Physiology in Wistar RatsJonah Sydney Aprioku, Victor Nwachukwu, Blessing Ukamaka Okeke et al.Garcina kola seed is believed by some to enhance male sexual performance but existing scientific data show divergent results. In this study, the sexual and reproductive influence of ethanol (70%) seed extract of G. kola was evaluated in Wistar rats. Adult male rats were gavaged with 0, 50, 100, 200 or 300 mg kg-1 day-1 of extract for 30 days … …American Journal of Pharmacology and Toxicology, Vol. 13, Issue 1 · 25 Apr 2018 · 13,804 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffect of Dayak Onion (Eleutherine bulbosa (Mill.) Urb) on Uterine wall and Lipid Profiles of Ovariectomized RatAmalia Purnamasari, Anton BahtiarMenopause is a physiologic condition, in which women no longer experience menstruation. Decreased estrogen during and after menopause causes structural, physiological and biochemical changes that alter the health of women in general, both in organs and non-reproductive organs. Dayak onion contains eleuterinol, an naphtoqunone derivative that can be as SERM. Therefore, we evaluated the effects of dayak onions on lipid … …OnLine Journal of Biological Sciences, Vol. 18, Issue 1 · 23 Dec 2017 · 9,996 accessesView PDFCite
Research ArticleOpen accessIn the abstractHippocampal Pyramidal Cell Degeneration and Changes in Creb Protein in Datura stramonium Treated RatsPeter Etim Ekanem, Dare S. Sunday, Sunday Abba, Amanuel TesfayDatura Stramonium (DS) is a tropical shrub which is available worldwide. It has various uses and is often used to increase the intoxication of certain beverages. The seeds of this plant are very toxic but are commonly smoked in like manner as tobacco. The present study investigated the potential harmful effects of DS on pyramidal cells and CREB protein in … …Neuroscience International, Vol. 6, Issue 2 · 17 Sep 2015 · 7,062 accessesView PDFCite
Research ArticleOpen accessIn the abstractCOMPARATIVE STUDY OF ANTIBACTERIAL ACTIVITY OF PLANT EXTRACTS FROM SEVERAL REGIONS OF ASIAAwatif Al-Judaibi, Ashwag Al-Zahrani, Khadijah A. Altammar et al.This study was designed to investigate the antibacterial activities of alcohol extracts of Phoenix dactylifera (date palm ’type Ajwa’), Nigella sativa (black cumin), Elettaria cardamomum (cardamom), Tinospora crispa (Akar patawali) and Panax ginseng (ginseng). The plant extracts were prepared with methanol and assayed for antibacterial activity against Methicillin-Resistant Staphylococcus Aureus (MRSA) and S. aureus. Extracts of N. sativa, E. cardamomum … …American Journal of Pharmacology and Toxicology, Vol. 9, Issue 2 · 2 Apr 2014 · 7,569 accessesView PDFCite
Research ArticleOpen accessIn the abstractConstitutive Androstane Receptor Dependent and Independent Modulation of CYP3A2, CYP1A2 by Phenobarbital and Fibrate in Rats’ LiverMohamed Mohamed Ahmed, Mustafa Shukry, Zein Shaban Ibrahim et al.Cytochrome P450 enzymes, CYP3A and CYP1A are major drug metabolizing enzymes in the liver. CYP3A enzymes have a major role in the metabolism of 30-40% of all used drugs. CYP1A2 is a key enzyme having an important role in the metabolic clearance of 5% of currently marketed drugs. CYP1A2 participates in the metabolic activation of chemical mutagens in cooked food, … …American Journal of Biochemistry and Biotechnology, Vol. 9, Issue 3 · 21 Sep 2013 · 7,381 accessesView PDFCite
Research ArticleOpen accessIn the abstractDietary Effects of Magnesium on Histamine Metabolism and Urine Acidity in Domestic FelinesSarah K. Martin, David L. Harmon, Charlotte E. Conway et al.Magnesium deficiency has been associated with increased histamine production in rats. Limitation of Mg with acidifying foods is common practice for management of urinary tract health in domestic cats. Nine healthy adult female shorthair cats were used in a 3 period random crossover experiment with fixed treatment sequences to test the effects of dietary Mg (0.06, 0.12 and 0.18% DM) … …American Journal of Animal and Veterinary Sciences, Vol. 7, Issue 4 · 29 Dec 2012 · 8,161 accessesView PDFCite
Research ArticleOpen accessIn the abstractAcute and Subchronic Toxicity of Mulberry FruitsJintanaporn Wattanathorn, Wipawee Thukummee, Cholathip Thipkaew et al.At present, the application of phytomedicine worldwide is substantial increase. The data of the acute and subchronic toxicity studies on medicinal plants or fruits and vegetables used for medicinal purposes should be obtained in order to increase the confidence in its safety to human, particularly for the application as functional food. Despite the widely consumption of mulberry (Morus alba L, … …American Journal of Agricultural and Biological Sciences, Vol. 7, Issue 3 · 19 Sep 2012 · 33,868 accessesView PDFCite
Research ArticleOpen accessIn the abstractQuercetin in Dimethyl Benzanthracene Induced Breast Cancer in RatsNatla Sashidhar Reddy, Parthasarathy Nirmala, Natesan Chidambaram, Pammi Ashok kumarProblem statement: Vincristine a commonly used anticancer agent in the treatment of breast cancer results in serious adverse effects like teratogenicity, neurotoxicity and carcinogenicity on long term use. Drug resistance is also a common problem encountered with vincristine. Hence the effect of flavonol quercetin, a known antioxidant with no known documented adverse effect was tried in treatment of DMBA induced … …American Journal of Pharmacology and Toxicology, Vol. 7, Issue 2 · 30 Jul 2012 · 8,138 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffect of Storing Temperature on Hepatotoxicity and Nephrotoxicity of Ifosfamide in Female RatFalah Mohammed AzizProblem statement: Ifosfamide (IFO) is a cytotoxic alkylating drug used for the treatment of a variety of cancers, although it has been found to induce certain hematological, hepatotoxic and nephrotoxic side effects. This drug is widely used in developing country, especially Iraq, but without caring too much to the storing temperature due to low drug maintaining facilities. The present work … …OnLine Journal of Biological Sciences, Vol. 12, Issue 1 · 19 Mar 2012 · 7,883 accessesView PDFCite
Research ArticleOpen accessIn the abstractMethamphetamine Regulation of Sulfotransferases in Rat Liver and BrainTianyan Zhou, Chaoqun Huang, Yue Chen et al.Problem statement: Sulfotransferases (SULTs) are important phase II drug metabolizing enzymes. They also regulate the biological activities of various hormones. To the best of our knowledge, psychostimulants regulation of SULTs is basically not studied except one article reported that Methamphetamine (METH) treatment induced rat amygdale rSULT1A1 mRNA 4.3 fold by using microarray method to identify a series of candidate genes … …American Journal of Pharmacology and Toxicology, Vol. 5, Issue 3 · 30 Sep 2010 · 7,683 accessesView PDFCite