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Research ArticleOpen accessIn the abstractQuercetin Iron (III) Complex Enhances Radiation-Induced Cell Death in Human Erythroleukemic Cell Lines by Increasing the Generation of Intracellular ROSJiraporn Kantapan, Krai Daowtak, Kachaporn Gateprayoon et al.Quercetin iron (III) complex (IronQ) is a paramagnetic agent which exhibits several biological effects. Despite extensive studies about quercetin metal complex, the role of complexes to enhance the effect of radiation still remains unexplored. To this end, we determined whether and how IronQ sensitizes cancer cells to Ionizing Radiation (IR). Doxorubicin resistant leukemic cells (K562/Adr) and their parental cell lines … …American Journal of Applied Sciences, Vol. 14, Issue 1 · 16 Jan 2017 · 8,068 accessesView PDFCite
Research ArticleOpen accessIn the abstractRadiation Triggered Phenotypic Changes of Regulatory T CellsLantao Liu, Yan Peng, Deqin Zhang, Dongsheng NiuIonizing radiation disrupts the immune balance easily. Regulatory T (Treg) cells directly affect the immune balance after radiation exposure. Meanwhile, the present study is to investigate the survival ability and phenotypic changes of Treg cells induced by 60Co γ-rays in order to expand the understanding on how Treg cells modulated by radiation. Mice lymphocytes were isolated from thymus and spleen … …American Journal of Biochemistry and Biotechnology, Vol. 18, Issue 1 · 20 Mar 2022 · 5,830 accessesView PDFCite
Research ArticleOpen accessIn the abstractInvestigating Effects of Water Conditioning on the Adhesion Properties of Crack SealantAhmed Lamarre, Elham H. Fini, Taher M. Abu-LebdehThis paper investigates the effect of water exposure on three different crack sealants commonly used in cold, moderate and hot climates. It is hypothesized that water penetrates into the interface between crack sealant and substrates causing progressive adhesion failure and that the rate of failure varies depending on the sealant’s surface chemistry as relates to its interaction with water molecules … …American Journal of Engineering and Applied Sciences, Vol. 9, Issue 1 · 14 Mar 2016 · 8,783 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffects of Cement Dust on the Physiological Activities of Arabidopsis thalianaSaeid Abu-Romman, Jarrah AlzubiAir pollution exerts detrimental effects on plant ecosystems and restricts agricultural productivity. Cement dust is considered to be one of the most harmful air pollutants of industrial origin and is a limiting factor for plant growth and productivity. This study aims to uncover the impacts of cement dust on photosynthetic pigments, protein content, hydrogen peroxide (H2O2) accumulation, lipid per oxidation … …American Journal of Agricultural and Biological Sciences, Vol. 10, Issue 4 · 17 Nov 2015 · 8,117 accessesView PDFCite
EditorialOpen accessIn the abstractImpact of Quantitative Pharmacology on Drug DevelopmentAna Ruiz-Garcia, Kourosh ParivarThesuccess of drug development rests over two well defined pillars, a goodunderstanding of the drug’s clinical pharmacology and the appropriate targetpopulation for whom the clinical use is intended. The label for human prescription drugsrequires a good understanding of the pharmacological effects (pharmacodynamicsor PD) and the mechanism of action of the drug as well as detailed informationof the drug’s Pharmacokinetics (PK): … …American Journal of Pharmacology and Toxicology, Vol. 9, Issue 4 · 24 Apr 2015 · 7,164 accessesView PDFCite
Research ArticleOpen accessIn the abstractStudy of Electromagnetic Radiation and Specific Absorption Rate of Mobile Phones with Fractional Human Head Models via Green's FunctionsNookala Srinivasa Rao, G. R. Babu, P. V.S. SrinivasProblem statement: Electromagnetic Radiation from mobile hand set is identified as one of the side effects for increasing rate of brain tumor. Due to this reason, Mobile phone industries are attentive towards safety issues of human health. Specific Absorption Rate is one of the important parameter while modeling the radiation effect on human head. Brain material with homogeneity is treated … …Journal of Computer Science, Vol. 7, Issue 8 · 16 Jul 2011 · 6,701 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffects of Hyperoxia on Brain Tissue Oxygen Tension in Non-Sedated, Non- Anesthetized Arctic Ground Squirrels: An Animal Model of Hyperoxic StressYilong Ma, Shufen Wu, Lawrence DuffyArctic Ground Squirrels (AGS) are classic hibernators known for their tolerance to hypoxia. AGS have been studied as a model of hypoxia with potential as a medical research model. Problem statement: Their unique resistance to the stressors of low oxygen led us to hypothesize that AGS might also be adaptable to hyperoxia. Approach: This study examined the physiological pattern associated … …American Journal of Animal and Veterinary Sciences, Vol. 6, Issue 1 · 26 Apr 2011 · 8,476 accessesView PDFCite
Research ArticleOpen accessIn the abstractMobile Phone Base Station Radiation Study for Addressing Public ConcernAiman Ismail, Norashidah Md Din, Md Zaini Jamaludin, Nagaletchumi BalasubramaniamProblem statement: The proliferation of mobile phone base stations had increased concerns from the public on the radio frequency radiation hazards that might come from them. The world wide public concern involved health risk due to radio frequency radiation. In Malaysia also public interest has increased, although it is not as intense as probably in other parts of the world, … …American Journal of Engineering and Applied Sciences, Vol. 3, Issue 1 · 31 Mar 2010 · 8,725 accessesView PDFCite
Research ArticleOpen accessIn the abstractP-Glycoprotein-Mediated Efflux and Drug Sequestration in Lysosomes Confer Advantages of K562 Multidrug Resistance Sublines to Survive Prolonged Exposure to Cytotoxic AgentsNathupakorn Dechsupa, Samlee MankhetkornProblem statement: Cellular drug resistance to anticancer agents is major obstacle in cancer chemotherapy and the mechanisms by which these MDR cells possess for protecting themselves to survive prolonged exposure to cytotoxic agents still debating. The study aimed to clarify the role of P-glycoprotein (Pgp) and enhanced drug sequestration in lysosomes to confer the multidrug resistance K562 cells with varied … …American Journal of Applied Sciences, Vol. 6, Issue 9 · 30 Sep 2009 · 7,508 accessesView PDFCite
Research ArticleOpen accessIn the abstractA Mathematical Modeling Approach to Characterize Hormesis, Caloric Restriction and Toxicity in Mortality Data from Toxicity StudiesPatricia J. NeafseyThe mortality of a population reflects the combined effects of natural aging with environmental insults (e.g. toxicant exposure, caloric restriction, over feeding, infections, etc.). No single endpoint, such as carcinogenesis, completely describes toxicant-induced effects in laboratory animals. Mathematical models of mortality and time-dependent exposure to toxicants can yield indices of net injury from all causes. With careful manipulation of diet … …American Journal of Pharmacology and Toxicology, Vol. 3, Issue 1 · 31 Mar 2008 · 7,163 accessesView PDFCite