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47 articles for “diabetic rats”
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Research ArticleOpen accessPhrase in the titleThe Beneficial Effect of Asiaticoside on Experimental Neuropathy in Diabetic RatsChonlathip Thipkaew, Jintanaporn Wattanathorn, Supaporn MuchimapuraThough diabetic neuropathy produces high impact on quality of life, annual cost and morbidities, the therapeutic efficacy is still not in a satisfaction level. Based on the crucial role of oxidative stress on the pathophysiology of diabetic neuropathy and the improvement of this condition induced by antioxidant, we hypothesized that asiaticoside, a substance possessing antioxidant activity, could provide beneficial effect. … …American Journal of Applied Sciences, Vol. 9, Issue 11 · 31 Aug 2012 · 7,051 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleEvaluation of Hyypoglycemic and Hypolipidemic Activity of Nyctanthes Arbortristis Linn against Streptozotocin Induced Diabetic RatsKrishna Murti, Manish Kaushik, Aditi KaushikProblem statement: The present study was aimed to explore the hypoglycemic and hypolipidemic activity of Nyctanthes arbortristis linn roots against Streptozotocin (STZ) induced experimental rats. Approach: Ethanolic extract of roots of Nyctanthes arbortristis was administered to streptozotocin induced rats.Glibenclamide was used as a standard drug. Blood glucose levels were determined after oral administration of a dose of Nyctanthes arbortristis (200 … …American Journal of Pharmacology and Toxicology, Vol. 7, Issue 1 · 3 Mar 2012 · 7,814 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleInteraction of Aqueous Extract of Trigonella Foenum-Graecum Seeds with Glibenclamide in Streptozotocin Induced Diabetic RatsV. K. Lal, P. P. Gupta, P. Tripathi, A. PandeyProblem statement: Interaction between herbs and drugs may increase or decrease the pharmacological or toxicological effects of either component. Herb traditionally used to decrease glucose concentrations in diabetes could theoretically precipitate hypoglycaemia if taken in combination with conventional drugs. Approach: The present study was undertaken to determine the interaction of Glibenclamide, a Sulphonylurea with Trigonella foenum-graecum seed extract, an herbal … …American Journal of Pharmacology and Toxicology, Vol. 6, Issue 4 · 31 Dec 2011 · 8,016 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleEffect of Hydro-Alcoholic Extract of Cucurbita Maxima, Fruit Juice and Glibenclamide on Blood Glucose in Diabetic RatsV. K. Lal, P. P. Gupta, Awanish Pandey, P. TripathiProblem statement: Cucurbita maxima has been used traditionally in Mexico, China and India as antidiabetic agents. Approach: The present study was to evaluate the hypoglycemic activity of fruit juice and hydro-alcoholic extract of Cucurbita maxima for validation of its folkloric use. Results: Hypoglycemic activity was evaluated on streptozotocin induced diabetic rats at the doses of 100 and 200 mg kg-1 … …American Journal of Pharmacology and Toxicology, Vol. 6, Issue 3 · 26 Nov 2011 · 8,277 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleThe Effect of Citrullus colocynthis Pulp Extract on the Liver of Diabetic Rats a Light and Scanning Electron Microscopic StudyMohammad Khalil, Gamal Mohamed, Mohammad Dallak et al.Problem statement: The goal of the current investigation was to clarify the effects of Citrullus colocynthis pulp extract on the structure of the liver of diabetic rats at both light and scanning electron microscopic levels. Approach: Forty-eight adult male albino rats were equally allocated into four groups: Group1: control, Group 2: Citrullus colocynthis-treated, Group 3: diabetic rats and Group4: diabetic … …American Journal of Biochemistry and Biotechnology, Vol. 6, Issue 3 · 30 Sep 2010 · 9,478 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleEffects of Leaf Extract of Urtica pilulifera L. on Male Reproductive System of Streptozotocin-Diabetic RatsFawzi Irshaid, Kamal MansiProblem statement: Urtica pilulifera L. (Urticaceae), has long been used for the treatment of various aliments including diabetes. Diabetes is a metabolic disorder characterized by hyperglycemia which has a deleterious effect on all systems including reproductive system of animals. Therefore, the current study was designed to investigate the effects of Urtica pilulifera on the reproductive system of diabetic rats. Approach: … …American Journal of Pharmacology and Toxicology, Vol. 4, Issue 2 · 30 Jun 2009 · 8,554 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleImpairment of Retrograde Neuronal Transport in Cardiac Vagal Motoneurons in Streptozotocin-Induced Diabetic Rats: A Wheat Ger Agglutinin-Horseradish Peroxidase Neurohistochemical studyA. Odekunle, C.M. PhillipsCentral projections of vagal motoneurons to the heart were studied in diabetic rats using Wheat germ Agglutinin-Horseradish peroxidase (WGA-HRP). Experimental rats were rendered diabetic by intraperitoneal injection of streptozotocin in citrate buffer. The diabetic rats were maintained in a stable diabetic state by daily injection of insulin for 24 weeks. Age-matched control rats were injected intraperitoneally with citrate buffer not … …OnLine Journal of Biological Sciences, Vol. 8, Issue 2 · 30 Jun 2008 · 6,740 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleAnti-Diabetic Activity of a Fraction from Cissus verticillata and Tyramine, its Main Bioactive Constituent, in Alloxan-Induced Diabetic RatsCleide de Sousa Lino, Thiago de P. Sales, Patrícia B. Gomes et al.Cissus verticillata (syn. C. sycioides, fam. Vitaceae) is a medicinal plant popularly used in Brazil, for the treatment of diabetes mellitus. The anti-diabetic activity of a fraction from leaves of Cissus verticilllata (MSF, methanol soluble fraction), as well as that of tyramine (TYR) were investigated, in the model of alloxan-induced diabetes, in male Wistar rats. The biochemical parameters studied were: … …American Journal of Pharmacology and Toxicology, Vol. 2, Issue 4 · 31 Dec 2007 · 8,627 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleAnti-hyperglycaemic and Hypolipidemic Effects of Ocimum basilicum Aqueous Extract in Diabetic RatsN.A. Zeggwagh, T. Sulpice, T. M. EddouksThe hypoglycaemic and hypolipidemic effects of the aqueous extract of Ocimum basilicum (OB) whole plant were investigated in normal and streptozotocin (STZ) diabetic rats. After a single oral administration, OB significantly reduced blood glucose levels in normal (p<0.01) and diabetic rats (p<0.001). After 15 days of repeated oral administration, OB produced a potent reduction on blood glucose levels (p<0.001) in … …American Journal of Pharmacology and Toxicology, Vol. 2, Issue 3 · 30 Sep 2007 · 8,719 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleInfluence of Ethanol Extract of Vinca rosea on Wound Healing in Diabetic RatsShivananda NayakVinca rosea (Catharanthus roseus L.) is native to the Caribbean Basin and has historically been used to treat a wide assortment of diseases. European herbalists used the plant for conditions as varied as headache to a folk remedy for diabetes. The objective of the study is to evaluate the diabetic wound healing activity of Vinca rosea using the excision wound … …OnLine Journal of Biological Sciences, Vol. 6, Issue 2 · 31 Dec 2006 · 7,416 accessesView PDFCite