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71 results for “biomarkers”
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Research ArticleOpen accessEvery word in the titleBiomarkers of Oxidative DNA Damage and Soluble Fas/Fas Ligand in Type 2 Diabetic PatientsMohamed H. Mahfouz, Ibrahim A. Emara, Ghada A. OmarProblem statement: Involvement of oxidative stress in the pathogenesis of diabetic complications has been proposed. 8-hydroxy-2'-deoxyguanosine (8-OHdG) has been reported to serve as a new sensitive biomarker of the oxidative DNA damage in vivo. Apoptosis via Fas/Fas Ligand (FasL) interactions has been proposed to be a major T-cell-mediated effector mechanism in autoimmune diabetes. This study was undertaken to investigate whether … …American Journal of Applied Sciences, Vol. 9, Issue 4 · 3 Feb 2012 · 7,110 accessesView PDFCite
Research ArticleOpen accessIn the keywordsTelomere Length and Gut Microbiota: Integrating Advanced Glycation End Products (Ages) With Artificial Intelligence for Understanding Premature AgingDiniwati Mukhtar, Hanifah HafsariPremature aging is characterized by an accelerated decline in biological functions, increasing the risk of chronic diseases. This review explores the interconnected roles of three critical biomarkers: Telomere Length, gut microbiota composition, and Advanced Glycation End Products (AGEs). These biomarkers exhibit bidirectional relationships, influencing one another and contributing to the aging process. Understanding their interplay provides valuable insights into the … …OnLine Journal of Biological Sciences, Vol. 25, Issue 3 · 3 Sep 2025 · 5,623 accessesView PDFCite
Research ArticleOpen accessIn the keywordsIsolation and Identification of Oral Cancer Stem Cells (CSC) within Commercially Available Cell LinesRobert Chauncey, Kai Hatch, Toni Jilka et al.Previous studies have demonstrated some tumors develop or maintain a small sub-population of cells with stem cell-like properties. This Cancer Stem Cells (CSC) may exhibit differential properties that allow their escape from traditional radiation or chemotherapy treatments and may therefore be responsible for cancer recurrence. Few studies have explored this phenomenon among oral cancer cell lines, therefore the objective of … …Current Research in Dentistry, Vol. 9, Issue 1 · 2 Jun 2018 · 12,722 accessesView PDFCite
Research ArticleOpen accessIn the keywordsAction of Calciotropic Hormones on Bone Metabolism-Role of Vitamin D3 in Bone Remodeling EventsCatharine Andresen, Ellen Olson, Chudy I. Nduaka et al.Vitamin D3 is known to have immunosuppressive effects that can be beneficial for treatment of immune disorders and transplant rejection, however therapeutic application is limited due to hypercalcemia and hypercalcuria. The goal of our studies was to explore both the acute and steady state effects of vitamin D3 on bone remodeling as potential limiting factors to broader use of vitamin … …American Journal of Immunology, Vol. 2, Issue 2 · 30 Jun 2006 · 8,821 accessesView PDFCite
Research ArticleOpen accessIn the keywordsProposed Insights in the Pharmaco-Dynamic Theory of Ascorbate Pro-Oxidant ActivityKheir Eddine Kerboua, Fatma Haiba, Fatima Bendjemia et al.Ascorbate pro-drug theory promising possible effective and nontoxic treatment is intensively examined and centered on the importance of both extracellular and intra-cellular effects of ascorbate. In this study, we sought to determine the in vitro cell responsiveness in a plasma free milieu with or without an extracellular catalyst and/or hydrogen peroxide. This project brought to light how ascorbic acid would … …OnLine Journal of Biological Sciences, Vol. 16, Issue 1 · 24 Nov 2015 · 6,969 accessesView PDFCite
Research ArticleOpen accessIn the keywordsRole of Progranulin Gene Expression as a Molecular Biomarker for Bladder CancerSalwa M. Abo El-khair, Mie A. Mohamed, Tamer E. AlkhiaryBladder cancer is the second most common cancer of the urinary system. Early diagnosis of this tumor and estimation of risk of future progression has a significant impact on prognosis. Although there are several molecular markers for the diagnosis and prognosis for this tumor, their accuracy is not ideal. Progranulin is a growth factor that may play a critical role … …American Journal of Biochemistry and Biotechnology, Vol. 8, Issue 2 · 22 Jun 2012 · 7,701 accessesView PDFCite
Research ArticleOpen accessIn the abstractImpact of Vitamin D Deficiency on Cardio Metabolic Ageing in Middle Aged Adults in India: A Comparative AnalysisSumit Kumar, Adithi K, Shailaja S MoodithayaAdvancing age is accompanied by a gradual deterioration in physiological function, resulting in an increased risk of chronic diseases and early mortality. Growing evidence suggests that inadequate vitamin D status may be associated with unfavourable metabolic and cardiovascular alterations. Nevertheless, information regarding the association of vitamin D status with integrated cardio-metabolic biomarkers of ageing in middle-aged adults is currently limited. … …OnLine Journal of Biological Sciences, Vol. 26, Issue 3 · 3 Sep 2026 · 738 accessesView PDFCite
Research ArticleOpen accessIn the abstractCorrelation of Some Tumor Markers Between Serum and Saliva of Patients with Breast CancerHuthaifa Tarawneh, Omar AtroozBreast cancer, which affects 36% of all female oncological patients, is the most frequent cancer in the world among women. Since routine laboratory evaluation of serum can be stressful for patients, it is critical to comprehend the features and limitations of salivary test methods in order to achieve an accurate diagnosis of breast cancer. The purpose of the study is … …OnLine Journal of Biological Sciences, Vol. 25, Issue 1 · 12 Oct 2024 · 4,909 accessesView PDFCite
Research ArticleOpen accessIn the abstractUMPM-Net: A Multimodal Deep Learning Framework for Colorectal Cancer PrognosisK. Muthuchamy, S K. Piramu PreethikaColorectal cancer (CRC) is one of the most common cancers worldwide, for which early prediction of patient outcomes is important for personalised treatment planning and to improve survival. However, current prediction systems are limited in the fact that they are based on single-modality data and cannot capture the complex interactions between clinical, imaging, and genomic factors. To overcome these shortcomings, … …Journal of Computer Science, Vol. 22, Issue 9 · 20 Sep 2026 · 621 accessesView PDFCite
Research ArticleOpen accessIn the abstractCA-LIME: A Collinearity-Aware LIME Framework for Reliable and Interpretable Explanations in Healthcare AIIdris Khan, Sachin BhoiteIn clinical tabular models, correlated biomarkers can make local explanations unstable even when predictive performance appears acceptable. This paper presents CA-LIME, a collinearity-aware extension of LIME built to address that failure mode directly. Five variations of CA-LIME Vanilla reference, VIF, PCA back projection, Ridge, and ElasticNet allow us to investigate how various correlation-control strategies alter explanation behavior. ILPD, Kaggle liver, … …Journal of Computer Science, Vol. 22, Issue 7 · 28 Jul 2026 · 813 accessesView PDFCite