Research ArticleOpen accessIn the abstractAutism Worldwide: Prevalence, Perceptions, Acceptance, ActionPatricia B. Kopetz, E. Desmond Lee EndowedThis metanalysis scrutinizes the growth of the neurodevelopment condition known as “autism” as a modern-day phenomenon. Over the past decade and worldwide, estimates of increases between 50% to over 2000% in cases of Autistic Disorder diagnoses have been charted, studied and discussed. The rise in diagnoses of autism impacts us all. The world seeks greater awareness and understanding of the … …Journal of Social Sciences, Vol. 8, Issue 2 · 22 Feb 2012 · 11,665 accessesView PDFCite
Research ArticleOpen accessIn the abstractEvidence of Mitochondrial Dysfunction in Autism and Implications for TreatmentDaniel A. Rossignol, J. Jeffrey BradstreetClassical mitochondrial diseases occur in a subset of individuals with autism and are usually caused by genetic anomalies or mitochondrial respiratory pathway deficits. However, in many cases of autism, there is evidence of mitochondrial dysfunction (MtD) without the classic features associated with mitochondrial disease. MtD appears to be more common in autism and presents with less severe signs and symptoms. … …American Journal of Biochemistry and Biotechnology, Vol. 4, Issue 2 · 30 Jun 2008 · 16,373 accessesView PDFCite
Research ArticleOpen accessIn the abstractMitochondrial Energy-Deficient Endophenotype in AutismJ. Jay Gargus, Faiqa ImtiazWhile evidence points to a multigenic etiology of most autism, the pathophysiology of the disorder has yet to be defined and the underlying genes and biochemical pathways they subserve remain unknown. Autism is considered to be influenced by a combination of various genetic, environmental and immunological factors; more recently, evidence has suggested that increased vulnerability to oxidative stress may be … …American Journal of Biochemistry and Biotechnology, Vol. 4, Issue 2 · 30 Jun 2008 · 11,507 accessesView PDFCite
Research ArticleOpen accessIn the abstractA Microscopic Study of Language-Related Cortex in AutismEdith López-Hurtado, Jorge J. PrietoImpaired language function is a principle criterion for the diagnosis of autism. The present study of brain from age-matched autistic and control subjects compared brain regions associated with the production and processing of speech. Wernicke's area (Brodmann 22, speech recognition), Broca's area (Brodmann 44, speech production) andthe gyrus angularis (Brodmann 39, reading) from autistic subjects (7-44 years of age) and … …American Journal of Biochemistry and Biotechnology, Vol. 4, Issue 2 · 30 Jun 2008 · 8,544 accessesView PDFCite
Research ArticleOpen accessIn the abstractAltered Sulfur Amino Acid Metabolism In Immune Cells of Children Diagnosed With AutismJung H. Suh, William J. Walsh, Woody R. McGinnis et al.Autism Spectrum Disorder (ASD) is a behaviorally defined neurodevelopmental disorder whose etiology is poorly understood. Recent studies have shown that autistic children may be experiencing increased inflammation and oxidative stress. Altered immune regulation may be one contributing factor to inflammation and oxidative stress in autistic children. Sulfur amino acid (SAA) metabolism plays a critical role in regulating blood leukocyte functions … …American Journal of Biochemistry and Biotechnology, Vol. 4, Issue 2 · 30 Jun 2008 · 10,789 accessesView PDFCite
Research ArticleOpen accessIn the abstractIncreased Copper-Mediated Oxidation of Membrane Phosphatidylethanolamine in AutismAbha Chauhan, Ashfaq M. Sheikh, Ved ChauhanWe have previously reported that levels of phosphatidylethanolamine (PE) in the erythrocyte membrane and of ceruloplasmin, a copper-transport antioxidant protein, in the serum are lower in children with autism than in control subjects. In the present study, we report that (a) copper oxidizes and reduces the levels of membrane PE and (b) copper-mediated oxidation of PE is higher in lymphoblasts … …American Journal of Biochemistry and Biotechnology, Vol. 4, Issue 2 · 30 Jun 2008 · 7,205 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Frequency of Polymorphisms affecting Lead and Mercury Toxicity among Children with AutismShannon Rose, Stepan Melnyk, Alena Savenka et al.Individual risk of developmental neurotoxicity with exposure to environmentally relevant levels of lead and mercury is likely to be determined by genetic susceptibility factors as well as additive interactions with other environmental pollutants, cumulative dose, and the developmental stage of exposure. The apparent increase in autism diagnosis over the last 15 years has enhanced interest in the possibility that an … …American Journal of Biochemistry and Biotechnology, Vol. 4, Issue 2 · 30 Jun 2008 · 7,521 accessesView PDFCite
Research ArticleOpen accessIn the abstractIdentification of Novel Chromosomal Abnormalities, inv(5)(p13q13) and t(7;18)(q32;q21), Associated with AutismZheng Chen, Xiao-bing Zou, Ya-nan Zhang et al.Autism is a neurodevelopmental disorder defined by impairments in social interaction, communication, as well as restricted and stereotyped behaviors. While the etiology of autism remains largely unknown, the existence of genetic components has been clearly demonstrated in autistic pathogenesis. The incidence of autism is 50-100 fold greater in the population with autistic family history than the general population. Chromosomal abnormalities … …American Journal of Biochemistry and Biotechnology, Vol. 3, Issue 3 · 30 Sep 2007 · 6,773 accessesView PDFCite