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Research ArticleOpen accessIn the abstractTranscriptomic Analysis of the Erythritol High-Yielding Mutant Strain Yarrowia lipolytica Y44Xiaojie Ren, Heng Ban, Chao Huang et al.RNA-seq technique was used to analyze the transcriptomics of Yarrowia lipolytica control strain Po1g, an erythritol-producing natural isolate Yarrowia lipolytica Y 22 and an erythritol high-yielding mutant strain Y44 derived from Y 22. Functional annotation of genes and classification of metabolic pathways were carried out to identify Differentially Expressed Genes (DEGs). These DEGs were classified into related metabolic pathways to … …American Journal of Biochemistry and Biotechnology, Vol. 17, Issue 4 · 20 Dec 2021 · 6,115 accessesView PDFCite
Research ArticleOpen accessIn the abstractMomordica balsamina Fruit Extracts Enhances Selected Aspects of the Insulin Synthesis/Secretion PathwayAnanias Hodi Kgopa, Leshweni Jerry Shai, Motetelo Alfred MogalePrevious studies have suggested that crude plant extracts of the anti-diabetic medicinal plant, Momordica balsamina (MB) may exert their anti-diabetic effect through either enhancement of insulin sensitivity or inhibition of intestinal glucose absorption. However, the effects of these MB extracts on insulin synthesis and secretion are not well documented in the literature. Therefore, a main purpose of the current research … …American Journal of Biochemistry and Biotechnology, Vol. 16, Issue 4 · 17 Dec 2020 · 6,999 accessesView PDFCite
Research ArticleOpen accessIn the abstractDifferential Gene Transcription in Red Oak (Quercus rubra) Genotypes Resistant to Copper ToxicityProulx Migueal, Paul Michael, Charnelle Djeukam, Kabwe NkongoloToxicity of metals is a major abiotic stressor of plants. Copper (Cu) is one of the most abundant metals in soils from the Greater Sudbury Region (GSR) due to its mining history. Recent studies have described several transporters and chelating proteins involved in copper resistance. Quercus rubra (Red Oak) is a common species that grows in metal contaminated soils in … …American Journal of Biochemistry and Biotechnology, Vol. 13, Issue 4 · 11 Dec 2017 · 8,545 accessesView PDFCite
Research ArticleOpen accessIn the abstractFrequency of Single Nucleotide Polymorphisms of the SLCO1B1 Gene in Slavic Population of Central EuropeMichaela Mikulová, Veronika Kramarova, Ján ChandogaThe organic anion transporting polypeptide 1B1 (encoded by SLCO1B1 gene) is involved in the active cellular influx of diverse endogenous compounds and several drugs, such as HMG-CoA reductase inhibitors (statins). Two common polymorphisms c.388A>G and c.521T>C in SLCO1B1 alter transport activity of this transporter and play an important role in the pharmaceutical response to many drugs. The aim of our … …OnLine Journal of Biological Sciences, Vol. 16, Issue 4 · 11 Dec 2016 · 7,308 accessesView PDFCite
Research ArticleOpen accessIn the abstractChanges in the Rumen Papillae During the Periparturient Transition in Holstein Dairy Cows are Accompanied by Changes in Abundance of Proteins Involved in Intracellular pH Regulation, But not SCFA TransportAnne Hermen Laarman, Adam Kleinberg, Michael Alexander Steele et al.The objective of this study was to examine changes in SCFA transport capacity in the rumen epithelium during the parturition transition period. Twelve pregnant, cannulated primiparous and multiparous cows were fed a standard Total Mixed Ration (TMR) for the duration of the dry period; after calving, all cows were switched to an early lactation TMR. Rumen pH, fluid and biopsies … …American Journal of Animal and Veterinary Sciences, Vol. 10, Issue 1 · 31 Mar 2015 · 7,546 accessesView PDFCite
Research ArticleOpen accessIn the abstractA SHORT INTERFERING RNA MOLECULAR BEACON FOR THE ATTENUATION OF MYCOBACTERIAL INFECTIONRemo George, Kathy Nugent, Norman Bolus et al.The ability of the pathogen Mycobacterium Tuberculosis (MTB) to invade and survive within macrophages of granulomas is attributed to the product of the Mammalian Cell Entry (MCE) operon whose gene, mce4A, encodes a cholesterol transporter that transports host lipids into the bacterium that allows the bacterium to survive during chronic infection. Here, we proposed and tested the hypothesis that a … …American Journal of Biochemistry and Biotechnology, Vol. 10, Issue 1 · 4 Mar 2014 · 7,774 accessesView PDFCite
Research ArticleOpen accessIn the abstractButyrate Supplementation Affects Mrna Abundance of Genes Involved in Glycolysis, Oxidative Phosphorylation and Lipogenesis in the Rumen Epithelium of Holstein Dairy CowsAnne Hermen Laarman, Louis Dionissopoulos, Ousama AlZahal et al.Energy availability in epithelial cells is a crucial link for maintaining epithelial barrier integrity; energy depletion is linked to impaired barrier function in several epithelia. This study aimed to elucidate the effects of exogenous butyrate on mRNA abundance of genes indirectly involved in rumen epithelial barrier integrity. Sixteen mid-lactation Holstein cows fed a total mixed ration received a concentrate mix … …American Journal of Animal and Veterinary Sciences, Vol. 8, Issue 4 · 27 Nov 2013 · 7,519 accessesView PDFCite
Research ArticleOpen accessIn the abstractAntioxidant and Photosynthetic Responses in Plants Under Boron Toxicity: A ReviewLucia Guidi, Alberto Pardossi, Elena Degl’Innocenti, Marco LandiBoron (B) is a micronutrient that has long been known essential not only for plants and animals. Otherwise, in crop plants the range of B concentration from essentiality to toxicity appears extremely narrow. Although B deficiency has been well investigated, during recent years many researchers have also investigated boron toxicity effects, making progress in the comprehension of boron transport within … …American Journal of Agricultural and Biological Sciences, Vol. 7, Issue 3 · 5 Jul 2012 · 12,762 accessesView PDFCite
Research ArticleOpen accessIn the abstractRal-Binding Protein is Required for the Maturation and Function of Dendritic CellsJozef Borvak, Mukesh Sahu, Varun Joy et al.Problem statement: Dendritic Cells (DCs) integrate responses of innate and adaptive immune system via transmitting pro-inflammatory and regulatory signals to naïve cells within draining lymph nodes. DCs have high capacity for endocytosis, both Clathrin-Dependent (CDE) and Caveolin-Dependent (CvDE). Approach: We have recently shown that ATP-hydrolysis by the multifunctional transporter protein RLIP76 is the primary determinant of the rate of CDE. … …American Journal of Immunology, Vol. 6, Issue 3 · 13 Sep 2010 · 8,095 accessesView PDFCite
Research ArticleOpen accessIn the abstractMolecular Mechanisms for Altered Glucose Homeostasis in HIV InfectionPaula W. HruzA complete understanding of the molecular mechanisms leading to HIV-associated insulin resistance remains elusive. Complex interrelationships between genetic predisposition, disease-related body changes and multidrug therapy all contribute to alterations in glucose homeostasis. These abnormalities can be differentiated between acute and reversible changes directly induced by HAART medications and more chronic and less reversible changes due to the development of lipodystrophy … …American Journal of Infectious Diseases, Vol. 2, Issue 3 · 30 Sep 2006 · 6,877 accessesView PDFCite