Research ArticleOpen accessIn the abstractComparative Functional Analysis of the Basic Helix-Loop-Helix Proteins in the Clawed Frogs' Genomes With Common Essential Pathways and Enriched Gene Ontology TermsWuyi LiuThe international Gene Ontology (GO) and pathway databases were used to functionally analyze the clawed frogs' Basic Helix-Loop-Helix (bHLH) transcription factors of Xenopus tropicalis and Xenopus laevis in a updated genome-wide survey. There were 41 GO terms and one pathway significantly enriched for Xenopus tropicalis, whereas there were 45 GO terms and 3 pathways significantly enriched for Xenopus laevis. Among … …American Journal of Biochemistry and Biotechnology, Vol. 15, Issue 1 · 28 Mar 2019 · 8,497 accessesView PDFCite
Research ArticleOpen accessIn the abstractRegulation of Gene Expression by β-GlucansMary O. Huff, Carolyn M. Klingeβ-D-glucans are diverse polysaccharides derived from plant cell walls, fungi and bacteria. β-D-glucans are composed of D-glucose monomers linked by (1-3) β-glycosidic bonds with varying amounts of (1-6) or (1-4) linked side chains that bind cell surface receptors ultimately triggering changes in intracellular pathways and gene transcription. β-D-glucans have anti-viral, immunomodulatory and anti-cancer activities. This article reviews the current identity … …American Journal of Immunology, Vol. 13, Issue 1 · 12 Apr 2017 · 7,557 accessesView PDFCite
Research ArticleOpen accessIn the abstractOverdominance Effects between Malaria and Visceral Leishmaniasis in the 5q31 RegionMutaz Amin, Abdelbadea Elhassan, Kirk Rocket, Muntasir IbrahimA group of SNPs in 5q31, genotyped from Hausa tribe of Koka village in eastern Sudan; an area endemic with malaria and visceral leishmaniasis, were analyzed by The Leishmaniasis research group and found to have significant excess of heterozygosis level and departure from HWE and assumed to be due to natural selection resulting from notorious deadly outbreaks since various ethnic … …OnLine Journal of Biological Sciences, Vol. 15, Issue 4 · 18 Sep 2015 · 7,119 accessesView PDFCite
Research ArticleOpen accessIn the abstractINDUCED PLURIPOTENT STEM CELLS AND THEIR IMPLICATION FOR BIOMEDICAL SCIENCESMaria Csobonyeiova, Stefan Polak, Lubos DanisovicThe groundbreaking discovery, that somatic mammalian cells can be epigenetically reprogrammed to a pluripotent state through the exogenous expression of the transcription factors Oct4, Sox2, Klf4 and c-myc, has yielded a new cell type for potential application in regenerative medicine, the induced Pluripotent Stem Cells (iPSCs). Since the first demonstration of creating iPSCs in 2006 great efforts have been made … …OnLine Journal of Biological Sciences, Vol. 13, Issue 4 · 3 Oct 2013 · 7,027 accessesView PDFCite
Research ArticleOpen accessIn the abstractIn Silico, In Vitro and In Vivo Assessment of Safety and Anti-inflammatory Activity of CurcuminM. Venkata, R. Sripathy, D. Anjana et al.Problem statement: Curcumin the active component of turmeric is known for its wide biological actions. Extensive studies on curcumin highlighted its anti-inflammatory, anti-oxidant, anti-microbial, anti-carcinogenic and anti-coagulant activity. The anti-inflammatory activities of curcumin have been demonstrated both in vitro and in vivo. Though curcumin and its anti-inflammatory properties are well documented, the exact mechanism of action and effective in vivo … …American Journal of Infectious Diseases, Vol. 8, Issue 1 · 23 Feb 2012 · 9,006 accessesView PDFCite
Research ArticleOpen accessIn the abstractA Sequence Based Validation of Gene Expression Microarray DataGerhard G. Thallinger, Eva Obermayr, Pornpimol Charoentong et al.Problem statement: Quantitative Reverse Transcription PCR (RT-qPCR) is often used to validate microarray data. Previous studies show different levels of correlation, without further investigation of influencing factors. Approach: We compared expression levels of 381 genes obtained from microarray hybridizations and from TaqMan based RT-qPCR assays. Correlation of expression levels was determined by comparing: (i) single genes across samples, (ii) all … …Current Research in Bioinformatics, Vol. 1, Issue 1 · 19 Jan 2012 · 13,722 accessesView PDFCite
Research ArticleOpen accessIn the abstractRole of AP-1 Antagonism in Growth Inhibition of Cervical Cancer Cell Lines by RetinoidsShennan Lu, Doris M. BenbrookRetinoid compounds induce multiple molecular effects that need to be taken into consideration in the development of theses agents as pharmaceuticals for cancer chemoprevention. Inhibition of cancer cell growth by retinoids is thought to occur through at least two mechanisms of transcriptional regulation resulting from direct binding of retinoids to nuclear retinoid receptors (RARs and RXR’s). First, the nuclear receptors … …American Journal of Pharmacology and Toxicology, Vol. 1, Issue 3 · 30 Sep 2006 · 7,481 accessesView PDFCite
Research ArticleOpen accessIn the abstractNeuropsychological Dysfunction among HIV Infected Drug AbusersRamani S. Durvasula, Charles H. HinkinHuman immunodeficiency virus (HIV) has been documented to cause direct and indirect central nervous system dysfunction that can be observed as a progressive decline in neuropsychological functioning in a large proportion of persons with HIV and AIDS. Neuropsychological decline in individuals with HIV is characterized by cognitive and motor slowing, attentional deficits, executive dysfunction and memory impairment (characterized by intact … …American Journal of Infectious Diseases, Vol. 2, Issue 2 · 30 Jun 2006 · 7,161 accessesView PDFCite